scholarly journals Naringenin-loaded solid lipid nanoparticles: preparation, controlled delivery, cellular uptake, and pulmonary pharmacokinetics

2016 ◽  
pp. 911 ◽  
Author(s):  
Chao Wu ◽  
Peng Ji ◽  
Tong Yu ◽  
Ying Liu ◽  
Jie Jiang ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Controlled Delivery ◽  
Solid Lipid

Anti-glioma activity and the mechanism of cellular uptake of asiatic acid-loaded solid lipid nanoparticles

2016 ◽  
Vol 500 (1-2) ◽  
pp. 305-315 ◽  
Author(s):  
Tanem Garanti ◽  
Aneta Stasik ◽  
Andrea Julie Burrow ◽  
Mohamed A. Alhnan ◽  
Ka-Wai Wan
Keyword(s):  
Cellular Uptake ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Asiatic Acid ◽  
Solid Lipid

scholarly journals Solid Lipid Nanoparticles of Albendazole for Enhancing Cellular Uptake and Cytotoxicity against U-87 MG Glioma Cell Lines

Molecules ◽  
2017 ◽  
Vol 22 (11) ◽  
pp. 2040 ◽  
Author(s):  
Gregory Marslin ◽  
Karthik Siram ◽  
Xiang Liu ◽  
Vinoth Khandelwal ◽  
Xiaolei Shen ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cellular Uptake ◽  
Solid Lipid Nanoparticles ◽  
Glioma Cell ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Glioma Cell Lines

Solid Lipid Nanoparticles for Topical Drug Delivery: Mechanisms, Dosage Form Perspectives, and Translational Status

2020 ◽  
Vol 26 (27) ◽  
pp. 3203-3217
Author(s):  
Mengyang Liu ◽  
Jingyuan Wen ◽  
Manisha Sharma
Keyword(s):  
Drug Delivery ◽  
Cellular Uptake ◽  
Solid Lipid Nanoparticles ◽  
Dosage Form ◽  
Scale Up ◽  
Form Factors ◽  
Skin Penetration ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Topical Applications

Solid lipid nanoparticles (SLNs) have shown potential as a novel lipid-based drug delivery system for the topical applications of innumerable therapeutic compounds. However, the mechanisms governing the absorption and cellular uptake of SLNs through topical route, along with the mechanism of drug release from SLNs are still ambiguous, and require further investigation. In addition, the selection of an appropriate dosage form/formulation base is essential for ease of application of SLNs and to enhance dermal and transdermal delivery. Upscaling and regulatory approvals are other challenges that may impede the clinical translation of SLNs. Therefore, this review focusses on different mechanisms involved in skin penetration and cellular uptake of SLNs. This is followed by a comprehensive discussion on the physicochemical properties of SLNs including various formulation and dosage form factors, which might influence the absorption of SLNs through the skin. Finally, translational status with respect to scale-up and regulatory aspects are also discussed. This review will be useful to researchers with an interest in topical applications of SLNs for the efficient delivery of drugs and cosmetics.

Improved formulation of cationic solid lipid nanoparticles displays cellular uptake and biological activity of nucleic acids

2017 ◽  
Vol 516 (1-2) ◽  
pp. 39-44 ◽  
Author(s):  
Anna Fàbregas ◽  
Silvia Prieto-Sánchez ◽  
Marc Suñé-Pou ◽  
Sofía Boyero-Corral ◽  
Josep Ramón Ticó ◽  
...  
Keyword(s):  
Biological Activity ◽  
Nucleic Acids ◽  
Cellular Uptake ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid
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