scholarly journals A Comparative Study on Insulin Secretion, Insulin Resistance and Thyroid Function in Patients with Polycystic Ovary Syndrome with and without Hashimoto’s Thyroiditis

2021 ◽  
Vol Volume 14 ◽  
pp. 1817-1821
Author(s):  
Hongli Zhao ◽  
Ying Zhang ◽  
Jianhong Ye ◽  
Hongjiang Wei ◽  
Zhengping Huang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Secretion ◽  
Polycystic Ovary Syndrome ◽  
Comparative Study ◽  
Thyroid Function ◽  
Hashimoto’S Thyroiditis ◽  
Polycystic Ovary ◽  
Hashimoto's Thyroiditis ◽  
Ovary Syndrome

scholarly journals Hashimoto’s thyroiditis might increase polycystic ovary syndrome and associated comorbidities risks in Asia

2020 ◽  
Vol 8 (11) ◽  
pp. 684-684
Author(s):  
Chun-Wei Ho ◽  
Hsin-Hung Chen ◽  
Ming-Chia Hsieh ◽  
Ching-Chu Chen ◽  
Sheng-Pang Hsu ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Hashimoto’S Thyroiditis ◽  
Polycystic Ovary ◽  
Hashimoto's Thyroiditis ◽  
Ovary Syndrome

scholarly journals A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME

2021 ◽  
Vol 71 (5) ◽  
pp. 1746-50
Author(s):  
Amena Arif ◽  
Palvasha Waheed ◽  
Robina Anees ◽  
Amir Rashid ◽  
Saleem Ahmed Khan
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Comparative Study ◽  
Polycystic Ovary ◽  
Serum Insulin ◽  
Insulin Level ◽  
Normal Weight ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Control Subjects

Objective: To assess the relationship between obesity and insulin resistance in polycystic ovary syndrome affected women. Study Design: Cross sectional comparative study. Place and Duration of Study: Multidisciplinary Lab-I of Department of Biochemistry, Army Medical College, Rawalpindi, in collaboration with Pakistan Naval Ship Hafeez Hospital, Islamabad from Feb 2018 to Jan 2019. Methodology: One hundred and five selected females (puberty till 25 years of age) were divided into three groups of 35 each. Blood samples were collected an overnight fast (from 8-11 AM). Serum level of insulin was measured and insulin resistance was calculated based on HOMA-IR. Results: HOMA-IR concentrations correlated directly with Basal Metabolic Index, fasting plasma glucose and serum insulin levels. Mean serum insulin level was also elevated in patients with polycystic ovary syndrome (normal weight & overweight) as compared to control subjects (7.4 ± 1.2 mIU/L & 9.1 ± 0.8 mIU/L vs 6.3 ± 1.1 mIU/L; p as 0.003). The insulin resistance was slightly higher in patients with polycystic ovary syndrome as compared to the control subjects (1.4 ± 0.3 & 1.7 ± 0.2 vs. 1.1 ± 0.3; p<0.001). Conclusion: HOMA-IR levels are positively associated with BMI, the intensity of peripheral insulin resistance in polycystic ovary syndrome-affected females, indicating that normal weight, and overweight patients with polycystic ovary syndrome have tendency towards insulin resistance.

High prevalence of Hashimoto’s thyroiditis in patients with polycystic ovary syndrome: does the imbalance between estradiol and progesterone play a role?

2015 ◽  
Vol 40 (4) ◽  
pp. 204-210 ◽  
Author(s):  
Ayse Arduc ◽  
Bercem Aycicek Dogan ◽  
Sevgi Bilmez ◽  
Narin Imga Nasiroglu ◽  
Mazhar Muslum Tuna ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Hashimoto’S Thyroiditis ◽  
Polycystic Ovary ◽  
Hashimoto's Thyroiditis ◽  
Ovary Syndrome ◽  
High Prevalence

scholarly journals A comparative study of combination of Myo-inositol and D-chiro-inositol versus Metformin in the management of polycystic ovary syndrome in obese women with infertility

2019 ◽  
Vol 8 (3) ◽  
pp. 825
Author(s):  
Sujana Thalamati
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Comparative Study ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Serum Lh ◽  
Symptom Complex ◽  
Group B

Background: Polycystic ovary syndrome (PCOS) is a symptom complex associated with increased amounts of circulating androgens in females, increased insulin resistance and obesity. The drugs, Myo-inositol, D-chiro-inositol and Metformin, which are insulin sensitizers, are very helpful in taking care of one of the key components of PCOS that is insulin resistance. This study was done to compare the effects of combination of Myo-inositol and D-chiro-inositol with the use of metformin on clinical and biochemical profile in PCOS.Methods: A prospective, randomized, comparative study was conducted on 200 patients. The patients were randomly assigned into the two groups of 100 each. Group A receiving Tab. Myoinositol 550mg twice daily and Tab. D-chiro-inositol 13.8mg twice daily and Group B receiving Tab. Metformin 500mg thrice daily. The patients were assessed by menstrual cycle regulation, hirsutism score (Ferriman Gallwey), fasting and post prandial glucose and insulin levels, serum DHEA levels, serum free testosterone levels and fasting day 3 serum LH and FSH ratio.Results: In both the groups there was significant improvement in all the above mentioned parameters, however the group with Combination of Myo-inositol and D-chiro-inositol had statistically significant improvement over the Metformin group.Conclusions: Combination of Myo-inositol and D-chiro-inositol and use of metformin, significantly improved insulin sensitivity in PCOS women. But combination of Myo-inositol and D-chiro-inositol was effective in controlling the hormonal profiles (LH/FSH ration and free testosterone) when compared to Metformin.

scholarly journals Genetic Susceptibility to Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto’s Thyroiditis: How Far Is Our Understanding?

2021 ◽  
Vol 12 ◽  
Author(s):  
Natalia Zeber-Lubecka ◽  
Ewa E. Hennig
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Hashimoto’S Thyroiditis ◽  
Genetic Factors ◽  
Polycystic Ovary ◽  
Hashimoto's Thyroiditis ◽  
Endocrine Disorders ◽  
Susceptibility Loci ◽  
Healthy Individuals ◽  
Ovary Syndrome ◽  
Joint Occurrence

Polycystic ovary syndrome (PCOS) and Hashimoto’s thyroiditis (HT) are endocrine disorders that commonly occur among young women. A higher prevalence of HT in women with PCOS, relative to healthy individuals, is observed consistently. Combined occurrence of both diseases is associated with a higher risk of severe metabolic and reproductive complications. Genetic factors strongly impact the pathogenesis of both PCOS and HT and several susceptibility loci associated with a higher risk of both disorders have been identified. Furthermore, some candidate gene polymorphisms are thought to be functionally relevant; however, few genetic variants are proposed to be causally associated with the incidence of both disorders together.

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