scholarly journals Management of complicated skin and soft tissue infections with a special focus on the role of newer antibiotics

2018 ◽  
Vol Volume 11 ◽  
pp. 1959-1974 ◽  
Author(s):  
Hoe Nam Leong ◽  
Asok Kurup ◽  
Mak Yong Tan ◽  
Andrea Lay Hoon Kwa ◽  
Kui Hin Liau ◽  
...  
Toxins ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 332 ◽  
Author(s):  
Patience Shumba ◽  
Srikanth Mairpady Shambat ◽  
Nikolai Siemens

Necrotizing soft tissue infections (NSTIs) are critical clinical conditions characterized by extensive necrosis of any layer of the soft tissue and systemic toxicity. Group A streptococci (GAS) and Staphylococcus aureus are two major pathogens associated with monomicrobial NSTIs. In the tissue environment, both Gram-positive bacteria secrete a variety of molecules, including pore-forming exotoxins, superantigens, and proteases with cytolytic and immunomodulatory functions. The present review summarizes the current knowledge about streptococcal and staphylococcal toxins in NSTIs with a special focus on their contribution to disease progression, tissue pathology, and immune evasion strategies.


2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Alessandro Russo ◽  
Enrico Maria Trecarichi ◽  
Carlo Torti

2012 ◽  
Vol 17 (44) ◽  
Author(s):  
T X Nhan ◽  
M Bes ◽  
H Meugnier ◽  
L Toko ◽  
G Julienne ◽  
...  

We describe the occurrence in France of a Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) ST93 clone, a predominant community-acquired (CA)-MRSA in Australia. In July to August 2012, an outbreak in a scout camp (n=3) and sporadic cases (n=2) of skin and soft tissue infections were reported. Investigations suggested importation of the clone through travel and onward transmission. This illustrates the epidemic potential of this lineage and the role of travellers in the spread of PVL-positive CA-MRSA.


2017 ◽  
Vol 20 (9) ◽  
pp. A782 ◽  
Author(s):  
YA Belkova ◽  
SA Rachina ◽  
RS Kozlov ◽  
AV Golub ◽  
US Portnyagina ◽  
...  

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