scholarly journals Highly sensitive detection of protein biomarkers via nuclear magnetic resonance biosensor with magnetically engineered nanoferrite particles

2016 ◽  
Vol Volume 11 ◽  
pp. 5497-5503 ◽  
Author(s):  
Minhong Jeun ◽  
Sungwook Park ◽  
Hakho Lee ◽  
Kwan Hyi Lee
2018 ◽  
Vol 6 (24) ◽  
pp. 4146-4150 ◽  
Author(s):  
Mengqi Zou ◽  
Daxiu Li ◽  
Ruo Yuan ◽  
Yun Xiang

Target-triggered operation of an aptamer machine leads to amplified and highly sensitive detection of protein biomarkers.


1966 ◽  
Vol 44 (3) ◽  
pp. 279-295 ◽  
Author(s):  
W. H. Lunn ◽  
J. T. Edward ◽  
Seymour Meyerson

Epimerization of 4-oxa-3-oxo-5α-cholestane by Brewster and Kucera's method gave only a 23% yield of the 5β-lactone; several other compounds were formed, apparently via skeletal rearrangement during hydrolysis of the tosylate. The attempted epimerization of 4-oxa-3-oxo-5β-cholestane gave mainly unsaturated acids, but no 5α-lactone (a small amount of skeletal rearrangement also occurred). Both epimers undergo rearrangement to γ-lactones when treated with trifluoroacetic acid.Mass spectra, used in conjunction with infrared and nuclear magnetic resonance spectra and other data to make structural assignments, were found to be highly sensitive to certain structural features. In particular, they can usually distinguish sharply between molecules that contain a pendant ring structure and those that do not.


ACS Nano ◽  
2012 ◽  
Vol 6 (11) ◽  
pp. 9637-9645 ◽  
Author(s):  
Jonilyn G. Longenecker ◽  
H. J. Mamin ◽  
Alexander W. Senko ◽  
Lei Chen ◽  
Charles T. Rettner ◽  
...  

1982 ◽  
Vol 60 (6) ◽  
pp. 787-791 ◽  
Author(s):  
G. W. Buchanan ◽  
J. B. Stothers

15N nuclear magnetic resonance chemical shifts are shown to be highly sensitive to site-selective diamagnetic metal ion binding for the nucleosides adenosine, cytidine, and guanosine. Conclusions regarding preferred complexation sites are compared with results derived from other physical measurements, and with expectations based on electron density calculations.


2009 ◽  
Vol 25 (1) ◽  
pp. 240-243 ◽  
Author(s):  
Wei Ma ◽  
Wei Chen ◽  
Ruirui Qiao ◽  
Chunyan Liu ◽  
Chunhui Yang ◽  
...  

2017 ◽  
Vol 29 (41) ◽  
pp. 1703787 ◽  
Author(s):  
Ying Fu ◽  
Naixiang Wang ◽  
Anneng Yang ◽  
Helen Ka-wai Law ◽  
Li Li ◽  
...  

Author(s):  
M.J. Hennessy ◽  
E. Kwok

Much progress in nuclear magnetic resonance microscope has been made in the last few years as a result of improved instrumentation and techniques being made available through basic research in magnetic resonance imaging (MRI) technologies for medicine. Nuclear magnetic resonance (NMR) was first observed in the hydrogen nucleus in water by Bloch, Purcell and Pound over 40 years ago. Today, in medicine, virtually all commercial MRI scans are made of water bound in tissue. This is also true for NMR microscopy, which has focussed mainly on biological applications. The reason water is the favored molecule for NMR is because water is,the most abundant molecule in biology. It is also the most NMR sensitive having the largest nuclear magnetic moment and having reasonable room temperature relaxation times (from 10 ms to 3 sec). The contrast seen in magnetic resonance images is due mostly to distribution of water relaxation times in sample which are extremely sensitive to the local environment.


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