scholarly journals Are adrenaline autoinjectors fit for purpose? A pilot study of the mechanical and injection performance characteristics of a cartridge- versus a syringe-based autoinjector

2010 ◽  
pp. 159 ◽  
Author(s):  
Andreas Schwirtz ◽  
Seeger
Keyword(s):  
Pilot Study ◽  
Performance Characteristics ◽  
Fit For Purpose

scholarly journals A mobile methods pilot study of surgical spaces: ‘fit for purpose? Organisational productivity and workforce wellbeing in workspaces in hospital’ (FLOURISH)

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Frances Rapport ◽  
Emilie Francis-Auton ◽  
John Cartmill ◽  
Tayhla Ryder ◽  
Jeffrey Braithwaite ◽  
...  
Keyword(s):  
Pilot Study ◽  
Fit For Purpose ◽  
Mobile Methods

scholarly journals Towards a Mathematical Framework for Method Validation and Performance Characteristics of Non-targeted Methods for Food Authenticity

2021 ◽  
Author(s):  
Kapil Nichani ◽  
Steffen Uhlig ◽  
Manfred Stoyke ◽  
Sabine Kemmlein ◽  
Franz Ulberth ◽  
...  
Keyword(s):  
Academic Research ◽  
Performance Characteristics ◽  
Mathematical Framework ◽  
Food Authenticity ◽  
Commercial Development ◽  
Official Control ◽  
Food And Feed ◽  
Fit For Purpose ◽  
New Form ◽  
And Performance

Through its suggestive name, non-targeted methods (NTMs) do not aim at a predefined "needle in the haystack". Instead, they exploit all the constituents of the haystack. This new form of analytical methods is increasingly finding applications in food and feed testing. However, the concepts, terms, and considerations related to this burgeoning field of analytical testing needs to be propagated for the benefit of ones associated in academic research, commercial development, and official control. This paper addresses the frequently asked questions around notations and terminologies surrounding NTMs. The widespread development and adoption of these methods also necessitates the need to develop approaches to NTM validation, i.e., evaluating the performance characteristics of a method to determine if it is fit-for-purpose. This work aims to provide a roadmap to approaching NTM validation. In doing so, the paper deliberates on the different considerations that influence the approach to validation and provides suggestions thereof.

Pilot study investigating diagnostic utility of serum MMP-1 and TGF-β1 in asthma in ‘real world’ clinical practice in India

2021 ◽  
pp. jclinpath-2020-206821
Author(s):  
Aswani Prabha ◽  
Komarla Sundararaja Lokesh ◽  
S K Chaya ◽  
B S Jayaraj ◽  
Sowmya Malamardi ◽  
...  
Keyword(s):  
Pilot Study ◽  
Severe Asthma ◽  
Predictive Value ◽  
Transforming Growth Factor ◽  
Persistent Asthma ◽  
Performance Characteristics ◽  
Therapeutic Monitoring ◽  
Moderate Asthma ◽  
Severe Persistent Asthma ◽  
Tgf Β1

AimsAt a tissue level, matrix metalloproteinase-1 (MMP-1) and transforming growth factor-beta 1 (TGF-β1) contribute to allergic airway inflammation, tissue remodelling and disease severity in asthma via different pathways. Their peripheral blood levels and role in diagnosis and therapeutic monitoring has not been adequately explored. We investigated the association between MMP-1 and TGF-β in moderate and severe persistent asthma and evaluated their performance characteristics by constructing receiver operating characteristic curves.MethodsSerum MMP-1 and TGF-β1 were measured using ELISA in 75 adults; moderate persistent asthma (n=25), severe persistent asthma (n=25) and healthy community controls (n=25). Severity of asthma was determined as per Global Initiative for Asthma guidelines. Subjects were followed up for 3 months and treatment responsiveness was assessed by spirometry and symptom response.ResultsSerum MMP-1 and TGF-β1 were significantly elevated in asthmatics compared with controls (p<0.0001 and p<0.01). While serum MMP-1 was elevated in severe asthma compared with moderate asthma (p<0.05), TGF-β1 was lower in severe asthma compared with moderate asthma (p<0.05). The performance characteristics of serum MMP-1 and TGF-β1 were promising in this cohort with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 82%, 100%, 100% and 99% and 62%, 100%, 100% and 97.8%, respectively; sensitivity of MMP-1 being superior.ConclusionThis pilot study showed that serum MMP-1 and TGF-β1 levels are elevated in chronic asthma and may serve as a useful adjunct in differentiating moderate from severe asthma. A large multicentre study in well characterised cohort of asthmatics is warranted to investigate their role in diagnosis and therapeutic monitoring.

scholarly journals Essential Terminology and Considerations for Validation of Non-targeted Methods

2021 ◽  
Author(s):  
Kapil Nichani ◽  
Steffen Uhlig ◽  
Manfred Stoyke ◽  
Sabine Kemmlein ◽  
Franz Ulberth ◽  
...  
Keyword(s):  
Analytical Methods ◽  
Academic Research ◽  
Performance Characteristics ◽  
Commercial Development ◽  
Official Control ◽  
Food And Feed ◽  
Fit For Purpose ◽  
New Form

Through its suggestive name, non-targeted methods (NTMs) do not aim at a predefined "needle in the haystack". Instead, they exploit all the constituents of the haystack. This new form of analytical methods is increasingly finding applications in food and feed testing. However, the concepts, terms, and considerations related to this burgeoning field of analytical testing needs to be propagated for the benefit of ones associated in academic research, commercial development, and official control. This paper addresses the frequently asked questions around notations and terminologies surrounding NTMs. The widespread development and adoption of these methods also necessitates the need to develop approaches to NTM validation, i.e., evaluating the performance characteristics of a method to determine if it is fit-for-purpose. This work aims to provide a roadmap to approaching NTM validation. In doing so, the paper deliberates on the different considerations that influence the approach to validation and provides suggestions thereof.

Pilot study on criteria in cavity preparation-facts or artifacts?

1973 ◽  
Vol 37 (11) ◽  
pp. 27-31 ◽  
Author(s):  
G Salvendy ◽  
WM Hinton ◽  
GW Ferguson ◽  
PR Cunningham
Keyword(s):  
Pilot Study ◽  
Cavity Preparation

A Pilot Study of Early Storybook Reading With Babies With Hearing Loss

2019 ◽  
Vol 62 (9) ◽  
pp. 3397-3412
Author(s):  
Michelle I. Brown ◽  
David Trembath ◽  
Marleen F. Westerveld ◽  
Gail T. Gillon
Keyword(s):  
Hearing Loss ◽  
Pilot Study ◽  
Visual Analysis ◽  
Single Case ◽  
Eye Contact ◽  
Preliminary Evidence ◽  
Storybook Reading ◽  
Book Selection ◽  
Turn Taking ◽  
Parent Child

Purpose This pilot study explored the effectiveness of an early storybook reading (ESR) intervention for parents with babies with hearing loss (HL) for improving (a) parents' book selection skills, (b) parent–child eye contact, and (c) parent–child turn-taking. Advancing research into ESR, this study examined whether the benefits from an ESR intervention reported for babies without HL were also observed in babies with HL. Method Four mother–baby dyads participated in a multiple baseline single-case experimental design across behaviors. Treatment effects for parents' book selection skills, parent–child eye contact, and parent–child turn-taking were examined using visual analysis and Tau-U analysis. Results Statistically significant increases, with large to very large effect sizes, were observed for all 4 participants for parent–child eye contact and parent–child turn-taking. Limited improvements with ceiling effects were observed for parents' book selection skills. Conclusion The findings provide preliminary evidence for the effectiveness of an ESR intervention for babies with HL for promoting parent–child interactions through eye contact and turn-taking.

Sign in / Sign up

Export Citation Format

Share Document