scholarly journals Reduced serum paraoxonase 1 (PON1) activity in patients with schizophrenia treated with olanzapine but not quetiapine

2013 ◽  
pp. 1545 ◽  
Author(s):  
Yakup Albayrak ◽  
Cüneyt Ünsal ◽  
Neslihan Albayrak ◽  
Murat Kuloglu ◽  
Kenji Hashimoto
Keyword(s):  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Serum Paraoxonase

Longitudinal changes in serum paraoxonase-1 activity throughout normal pregnancy

2006 ◽  
Vol 44 (7) ◽  
Author(s):  
Natàlia Ferré ◽  
Jordi Camps ◽  
Joan Fernández-Ballart ◽  
Victoria Arija ◽  
Michelle M. Murphy ◽  
...  
Keyword(s):  
Vitamin C ◽  
Normal Pregnancy ◽  
Paraoxonase 1 ◽  
Dietary Vitamin ◽  
Pon1 Activity ◽  
Longitudinal Changes ◽  
Increased Risk ◽  
Direct Association ◽  
Vitamin C Supplementation ◽  
Serum Paraoxonase

AbstractThe aim of this study was to investigate the longitudinal changes in serum paraoxonase-1 (PON1) activity from preconception throughout normal pregnancy and their relationships with maternal dietary vitamin C and E intake. The study was performed in 35 women (studied at preconception, at 8, 20 and 32weeks of pregnancy, and at labour). PON1 activity decreased significantly from 145.8 (109.8–198.8) U/L at preconception to 111.1 (85.3–179.9) U/L (p<0.01) at 32weeks and 100.4 (54.7–171.4) U/L (p<0.001) at labour. There was a direct association between vitamin C intake and PON1 at week 32 (p=0.018). We conclude that adequate vitamin C intake in pregnant women may merit consideration, since vitamin C supplementation has proved beneficial in the prevention of preeclampsia in women at increased risk of this condition.Clin Chem Lab Med 2006;44:880–2.

Serum paraoxonase 1 (PON1) activity in acute pancreatitis of dogs

2014 ◽  
Vol 56 (1) ◽  
pp. 67-71 ◽  
Author(s):  
A. Tvarijonaviciute ◽  
J. D. García-Martínez ◽  
M. Caldin ◽  
S. Martínez-Subiela ◽  
F. Tecles ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Serum Paraoxonase

Acetaminophen intoxication is associated with decreased serum paraoxonase and arylesterase activities and increased lipid hydroperoxide levels

2014 ◽  
Vol 33 (11) ◽  
pp. 1134-1140 ◽  
Author(s):  
S Karadas ◽  
M Aslan ◽  
H Gonullu ◽  
C Kati ◽  
L Duran ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Hydroperoxide ◽  
Radical Scavenging ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Toxicity Risk ◽  
Total Antioxidant ◽  
Acetaminophen Intoxication ◽  
Serum Paraoxonase ◽  
Serum Pon1 Activity

Background: Acetaminophen is at present one of the most commonly used analgesics and antipyretics. Recent evidence has suggested that oxidative stress is involved in the mechanism of acetaminophen intoxication. Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of this study was to evaluate the influence of serum PON1 activity and oxidative stress in patients with acetaminophen intoxication. Methods: A total of 20 patients with acetaminophen intoxication and 25 healthy controls were enrolled. Serum total antioxidant capacity (TAC), lipid hydroperoxide (LOOH) levels, and paraoxonase and arylesterase activities were measured spectrophotometrically. Results: The serum TAC levels and the paraoxonase and arylesterase activities were significantly lower in patients with acetaminophen intoxication compared with controls (all, p < 0.001), while the serum LOOH levels were significantly higher ( p < 0.001). Conclusions: Our results suggest that decreased PON1 activity seems to be associated with increased oxidative stress in patients with acetaminophen intoxication. Measuring serum PON1 activity may be useful in assessing the development of toxicity risk in acetaminophen toxicity. It would be useful to recommend vitamins with antioxidant effects such as vitamins C and E along with medical treatments.

Serum paraoxonase activity and oxidative stress levels in patients with cutaneous anthrax

2016 ◽  
Vol 36 (7) ◽  
pp. 663-669
Author(s):  
S Karadas ◽  
M Aslan ◽  
MR Ceylan ◽  
M Sunnetcioglu ◽  
N Bozan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Bacterial Disease ◽  
Healthy Controls ◽  
Paraoxonase Activity ◽  
Cutaneous Anthrax ◽  
Bacterium Bacillus ◽  
Serum Paraoxonase ◽  
And Oxidative Stress

Introduction: Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) levels in patients with cutaneous anthrax. Materials and methods: Fifteen patients with cutaneous anthrax and 15 healthy controls were enrolled in this study. The serum MDA levels, SOD levels, paraoxonase, arylesterase, and catalase activities were measured using a spectrophotometer. Results: The serum SOD levels, paraoxonase, arylesterase, and catalase activities were significantly lower in patients with cutaneous anthrax than in controls (for all, p < 0.001), whereas MDA levels were significantly higher ( p < 0.001). No significant correlation was found between serum paraoxonase activity, arylesterase activity, SOD levels, and MDA levels (all, p > 0.05) in patients with cutaneous anthrax. Conclusions: The current study was the first to show decreased antioxidant levels and increased oxidant levels in patients with cutaneous anthrax. Therefore, decreased PON1 activity may play a role in the pathogenesis of cutaneous anthrax.

Paraoxonase activity an indicator of complications at early stage of complicated pregnant cows

2017 ◽  
Author(s):  
Nazli Ercan ◽  
Beran Yokus ◽  
M. Gûn ◽  
Akin Koçhan
Keyword(s):  
Statistical Difference ◽  
Early Stage ◽  
Normal Pregnancy ◽  
Maternal Serum ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Serum Samples ◽  
Serum Paraoxonase ◽  
Serum Pon1 Activity ◽  
Early Phases

In healthy and complicated pregnant cows, on the 2nd and 6th months of pregnancy in order to determine the levels of maternal serum Paraoxonase 1 (PON1) activity and the possibility of complications can occur during the pregnancy might be a premise indication. Serum samples were taken at 2nd and 6th months of 252 pregnant cows at the end of their pregnancies. The cows were classified into two groups such as complicated (Abortion, Dystocia) and non-complicated. Maternal serum PON1 activity in 6th months was lower at complicated group than normally pregnant group (P=0.004; P less than 0.01), no difference was discovered between these groups in their 2nd month of pregnancy (P>0.05). Among the concentration of HDL, TP and globulin no statistical difference was observed between complicated, subgroups and normal births (P>0.05). Levels of PON1 in 2 and 6 months were statistically different between the groups of dystocia and normal pregnancy (P less than 0.01; P = 0.003), and abort and normal pregnancy (P less than 0.05; P=0.033). In this study, it was inferred that the evaluation of PON1 activity early indicator of complications for clinicians that might occur in further periods of pregnancy. These results showed the fact that PON1 activity can be used as a marker relatively at the early phases of pregnancy in complicated cows.

Effect of serum paraoxonase-1 (PON1) activity on follicular development and pregnancy rate in cattle

2018 ◽  
Vol 188 ◽  
pp. 130-136 ◽  
Author(s):  
Natália A. Castro ◽  
Luiz F.M. Pfeifer ◽  
Jéssica S. Andrade ◽  
Joao A.A. Rincón ◽  
Ligia M. Cantarelli Pegoraro ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Follicular Development ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Serum Paraoxonase

In vitro efficacy of some cattle drugs on bovine serum paraoxonase 1 (PON1) activity

2011 ◽  
Vol 27 (5) ◽  
pp. 722-729 ◽  
Author(s):  
Mikail Arslan ◽  
Nahit Gencer ◽  
Oktay Arslan ◽  
Ozen Ozensoy Guler
Keyword(s):  
Bovine Serum ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Serum Paraoxonase

scholarly journals Regulation of Hepatic Paraoxonase-1 Expression

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Bianca Fuhrman
Keyword(s):  
Gene Expression ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Atherosclerotic Lesions ◽  
Pon1 Gene ◽  
Increased Risk ◽  
Primary Determinant ◽  
Artery Disease ◽  
Atherosclerosis Development ◽  
Serum Paraoxonase

Serum paraoxonase-1 (PON1) is a member of the paraoxonases family (PON1, PON2, and PON3). PON1 is synthesized and secreted by the liver, and in circulation it is associated with HDL. PON1 has antioxidative properties, which are associated with the enzyme’s capability to decrease oxidative stress in atherosclerotic lesions and to attenuate atherosclerosis development. Epidemiological evidence demonstrates that low PON1 activity is associated with increased risk of cardiovascular events and cardiovascular disease and is an independent risk factor for coronary artery disease. Therefore, pharmacological modulation of PON1 activity or PON1 gene expression could constitute a useful approach for preventing atherosclerosis. A primary determinant of serum PON1 levels is the availability of the enzyme for release by the liver, the principal site of PON1 production. Together with the enzyme secretion rate, enzymatic turnover, and protein stability, the level of PON1 gene expression is a major determinant of PON1 status. This paper summarizes recent progress in understanding the regulation of PON1 expression in hepatocytes.

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