Longitudinal changes in serum paraoxonase-1 activity throughout normal pregnancy

2006 ◽  
Vol 44 (7) ◽  
Author(s):  
Natàlia Ferré ◽  
Jordi Camps ◽  
Joan Fernández-Ballart ◽  
Victoria Arija ◽  
Michelle M. Murphy ◽  
...  
Keyword(s):  
Vitamin C ◽  
Normal Pregnancy ◽  
Paraoxonase 1 ◽  
Dietary Vitamin ◽  
Pon1 Activity ◽  
Longitudinal Changes ◽  
Increased Risk ◽  
Direct Association ◽  
Vitamin C Supplementation ◽  
Serum Paraoxonase

AbstractThe aim of this study was to investigate the longitudinal changes in serum paraoxonase-1 (PON1) activity from preconception throughout normal pregnancy and their relationships with maternal dietary vitamin C and E intake. The study was performed in 35 women (studied at preconception, at 8, 20 and 32weeks of pregnancy, and at labour). PON1 activity decreased significantly from 145.8 (109.8–198.8) U/L at preconception to 111.1 (85.3–179.9) U/L (p<0.01) at 32weeks and 100.4 (54.7–171.4) U/L (p<0.001) at labour. There was a direct association between vitamin C intake and PON1 at week 32 (p=0.018). We conclude that adequate vitamin C intake in pregnant women may merit consideration, since vitamin C supplementation has proved beneficial in the prevention of preeclampsia in women at increased risk of this condition.Clin Chem Lab Med 2006;44:880–2.

Paraoxonase activity an indicator of complications at early stage of complicated pregnant cows

2017 ◽  
Author(s):  
Nazli Ercan ◽  
Beran Yokus ◽  
M. Gûn ◽  
Akin Koçhan
Keyword(s):  
Statistical Difference ◽  
Early Stage ◽  
Normal Pregnancy ◽  
Maternal Serum ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Serum Samples ◽  
Serum Paraoxonase ◽  
Serum Pon1 Activity ◽  
Early Phases

In healthy and complicated pregnant cows, on the 2nd and 6th months of pregnancy in order to determine the levels of maternal serum Paraoxonase 1 (PON1) activity and the possibility of complications can occur during the pregnancy might be a premise indication. Serum samples were taken at 2nd and 6th months of 252 pregnant cows at the end of their pregnancies. The cows were classified into two groups such as complicated (Abortion, Dystocia) and non-complicated. Maternal serum PON1 activity in 6th months was lower at complicated group than normally pregnant group (P=0.004; P less than 0.01), no difference was discovered between these groups in their 2nd month of pregnancy (P>0.05). Among the concentration of HDL, TP and globulin no statistical difference was observed between complicated, subgroups and normal births (P>0.05). Levels of PON1 in 2 and 6 months were statistically different between the groups of dystocia and normal pregnancy (P less than 0.01; P = 0.003), and abort and normal pregnancy (P less than 0.05; P=0.033). In this study, it was inferred that the evaluation of PON1 activity early indicator of complications for clinicians that might occur in further periods of pregnancy. These results showed the fact that PON1 activity can be used as a marker relatively at the early phases of pregnancy in complicated cows.

scholarly journals Regulation of Hepatic Paraoxonase-1 Expression

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Bianca Fuhrman
Keyword(s):  
Gene Expression ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Atherosclerotic Lesions ◽  
Pon1 Gene ◽  
Increased Risk ◽  
Primary Determinant ◽  
Artery Disease ◽  
Atherosclerosis Development ◽  
Serum Paraoxonase

Serum paraoxonase-1 (PON1) is a member of the paraoxonases family (PON1, PON2, and PON3). PON1 is synthesized and secreted by the liver, and in circulation it is associated with HDL. PON1 has antioxidative properties, which are associated with the enzyme’s capability to decrease oxidative stress in atherosclerotic lesions and to attenuate atherosclerosis development. Epidemiological evidence demonstrates that low PON1 activity is associated with increased risk of cardiovascular events and cardiovascular disease and is an independent risk factor for coronary artery disease. Therefore, pharmacological modulation of PON1 activity or PON1 gene expression could constitute a useful approach for preventing atherosclerosis. A primary determinant of serum PON1 levels is the availability of the enzyme for release by the liver, the principal site of PON1 production. Together with the enzyme secretion rate, enzymatic turnover, and protein stability, the level of PON1 gene expression is a major determinant of PON1 status. This paper summarizes recent progress in understanding the regulation of PON1 expression in hepatocytes.

scholarly journals Reduced serum paraoxonase 1 (PON1) activity in patients with schizophrenia treated with olanzapine but not quetiapine

2013 ◽  
pp. 1545 ◽  
Author(s):  
Yakup Albayrak ◽  
Cüneyt Ünsal ◽  
Neslihan Albayrak ◽  
Murat Kuloglu ◽  
Kenji Hashimoto
Keyword(s):  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Serum Paraoxonase

scholarly journals Paraoxonase 1 Phenotype and Protein N-Homocysteinylation in Patients with Rheumatoid Arthritis: Implications for Cardiovascular Disease

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 899
Author(s):  
Jolanta Parada-Turska ◽  
Grażyna Wójcicka ◽  
Jerzy Beltowski
Keyword(s):  
Rheumatoid Arthritis ◽  
Protein Concentration ◽  
Serum Proteins ◽  
Density Lipoprotein ◽  
Cardiovascular Complications ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Phenyl Acetate ◽  
Control Subjects ◽  
Increased Risk

Paraoxonase 1 (PON1) is the high density lipoprotein-associated esterase which inhibits the development of atherosclerosis by metabolizing lipid peroxidation products as well as hydrolyzing proatherogenic metabolite of homocysteine (Hcy), Hcy thiolactone, which otherwise reacts with lysine groups of proteins, thus forming N-Hcy-protein in a process referred to as protein N-homocysteinylation. Rheumatoid arthritis (RA) is the chronic inflammatory autoimmune disease associated with increased risk of cardiovascular complications, but the underlying mechanisms are incompletely understood. We examined PON1 status and N-homocysteinylation of serum proteins in patients with RA. Blood was collected from 74 RA patients and 70 control subjects. PON1 activity was measured toward synthetic (paraoxon, phenyl acetate) and natural (Hcy thiolactone) substrates. PON1 protein concentration was measured by ELISA. Total Hcy as well as N-Hcy-protein were measured in serum as well. PON1 activity toward Hcy thiolactone was lower in RA patients than in control subjects which was accompanied by increased concentration of N-Hcy-protein despite normal total Hcy concentration. PON1 protein concentration was unchanged in the RA group, but the specific enzyme activity was reduced. When RA patients were categorized according to the DAS28-ESR score, PON1 concentration and enzymatic activity were lower whereas N-Hcy-protein was higher in those with high disease activity. PON1 activity and Hcy thiolactone were correlated with DAS28-ESR score and myeloperoxidase concentration. In conclusion, RA is associated with deficiency of PON1 activity and increased protein N-homocyseinylation which may contribute to accelerated development of cardiovascular diseases.

Dietary vitamin C supplementation reduces noise-induced hearing loss in guinea pigs

2005 ◽  
Vol 202 (1-2) ◽  
pp. 200-208 ◽  
Author(s):  
Sandra L. McFadden ◽  
Jenifer M. Woo ◽  
Nathan Michalak ◽  
Dalian Ding
Keyword(s):  
Hearing Loss ◽  
Vitamin C ◽  
Guinea Pigs ◽  
Dietary Vitamin ◽  
Noise Induced Hearing Loss ◽  
Vitamin C Supplementation

scholarly journals Vitamin C intake and susceptibility to the common cold

1997 ◽  
Vol 77 (1) ◽  
pp. 59-72 ◽  
Author(s):  
Harri Hemilä
Keyword(s):  
Vitamin C ◽  
Common Cold ◽  
Potential Effect ◽  
Dietary Vitamin ◽  
High Dose ◽  
Plasma Vitamin ◽  
Vitamin C Supplementation ◽  
The Common ◽  
The Uk

Although the role of vitamin C in common cold incidence had been studied extensively, the level of vitamin C intake has not been unequivocally shown to affect the incidence of colds. In the present study the six largest vitamin C supplementation (≥ 1 g/d) studies, including over 5000 episodes in all, have been analysed, and it is shown that common cold incidence is not reduced in the vitamin C-supplemented groups compared with the placebo groups (pooled rate ratio (RR) 0·99; 95% CI 0·93, 1·04). Consequently these six major studies give no evidence that high-dose vitamin C supplementation decreases common cold incidence in ordinary people. Nevertheless, the analysis was continued with the hypothesis that vitamin C intake may affect common cold susceptibility in specific groups of people. It was assumed that the potential effect of supplementation might be most conspicuous in subjects with low dietary vitamin C intake. The average vitamin C intake has been rather low in the UK and plasma vitamin C concentrations are in general lower in males than in females. In four studies with British females vitamin C supplementation had no marked effect on common cold incidence (pooled RR 0·95; 95% CI 0·86, 1·04). However, in four studies with British male schoolchildren and students a statistically highly significant reduction in common cold incidence was found in groups supplemented with vitamin C (pooled RR 0·70; 95% CI 0·60, 0·81). Thus, these studies with British males indicate that vitamin C intake has physiological effects on susceptibility to common cold infections, although the effect seems quantitatively meaningful only in limited groups of people and is not very large.

Impaired Antiatherogenic Functions of High-density Lipoprotein in Patients with Ankylosing Spondylitis

2015 ◽  
Vol 42 (9) ◽  
pp. 1652-1660 ◽  
Author(s):  
Christina Gkolfinopoulou ◽  
Efstratios Stratikos ◽  
Dimitris Theofilatos ◽  
Dimitris Kardassis ◽  
Paraskevi V. Voulgari ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
High Density Lipoprotein ◽  
Antioxidant Capacity ◽  
Cholesterol Efflux ◽  
Density Lipoprotein ◽  
High Density ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Akt Kinase ◽  
Increased Risk

Objective.Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with increased risk of cardiovascular disease (CVD). High-density lipoprotein (HDL) exerts a series of antiatherogenic properties and protects from CVD. We evaluated whether HDL antiatherogenic properties are impaired in patients with AS.Methods.HDL (apoB-depleted serum) was isolated from 35 patients with AS and 35 age- and sex-matched controls. We measured the antioxidant capacity of HDL, the ability of HDL to induce cholesterol efflux, the activity of HDL-associated enzymes paraoxonase-1 (PON1) and myeloperoxidase (MPO), as well as the ability of HDL to induce Akt kinase activation.Results.HDL from patients with AS had decreased antioxidant capacity and decreased ability to promote cholesterol efflux from macrophages compared to controls. HDL-associated PON1 activity was lower and HDL-associated MPO activity higher in patients with AS compared to controls. Higher MPO activity correlated positively with lower antioxidant capacity of HDL in patients with AS. In addition, HDL from patients with AS had impaired endothelial Akt kinase activating properties that were inversely correlated with the MPO/PON1 ratio and positively correlated with the cholesterol efflux capacity of HDL.Conclusion.HDL from patients with AS displays impaired antiatherogenic properties. Attenuation of HDL properties may constitute a link between AS and CVD.

Serum paraoxonase 1 (PON1) activity in acute pancreatitis of dogs

2014 ◽  
Vol 56 (1) ◽  
pp. 67-71 ◽  
Author(s):  
A. Tvarijonaviciute ◽  
J. D. García-Martínez ◽  
M. Caldin ◽  
S. Martínez-Subiela ◽  
F. Tecles ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Serum Paraoxonase

scholarly journals Effects of dietary vitamin C supplementation on fatty acid profile in breast meat of broiler chickens

Meso ◽  
2020 ◽  
Vol 22 (4) ◽  
pp. 268-273
Author(s):  
Masoomeh Tavakoli ◽  
Mehrdad Bouyeh ◽  
Alireza Seidavi
Keyword(s):  
Fatty Acid ◽  
Vitamin C ◽  
Fatty Acid Profile ◽  
Broiler Chickens ◽  
Dietary Vitamin ◽  
Breast Meat ◽  
Vitamin C Supplementation

Ziel der Studie war es, die Auswirkungen der Aufnahme von drei verschiedenen Vitamin C-Mengen (0, 200 und 400 mg / kg) in die Ernährung auf das Fettsäureprofil im Broilerbrustfleisch zu bewerten. Die Studie wurde in 3 Zyklen und 4 Wiederholungen in Dauer von 42 Tagen durchgeführt, an einer vollständig randomisierten Probe von 10 Hühnern pro Käfig, insgesamt 120 männliche Hühner im Alter von einem Tag des kommerziellen Hybrids Ross 308. Die Datenanalyse wurde unter Verwendung des statistischen SAS-Analyseprogramms vorgenommen, während der Vergleich der Mittelwerte mit dem Duncan multiplen Vergleichstest mit einer Fehlerwahrscheinlichkeit von 5% durchgeführt wurde. Die Ergebnisse zeigten, dass die Zugabe von Vitamin C in einer Menge von 200 mg / kg den Prozentsatz an gesättigten Fettsäuren wie Myristinsäure, Palmitinsäure und Stearinsäure verringert, wobei die Menge an ungesättigten Fettsäuren zunahm und die Menge an gesättigten Fettsäuren abnahm

scholarly journals Differing Relations to Early Atherosclerosis between Vitamin C from Supplements vs. Food in the Los Angeles Atherosclerosis Study: A Prospective Cohort Study

2012 ◽  
Vol 6 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Megha Agarwal ◽  
Puja K Mehta ◽  
James H Dwyer ◽  
Kathleen M Dwyer ◽  
Anne M Shircore ◽  
...  
Keyword(s):  
Vitamin C ◽  
Serum Cholesterol ◽  
Critical Role ◽  
Dietary Vitamin ◽  
Vitamin Supplement ◽  
Carotid Imt ◽  
Vitamin C Supplementation ◽  
The Impact ◽  
Supplement Intake ◽  
Early Atherosclerosis

Objective:To determine the relationship of vitamin c intake from supplements vs food on early atherosclerosis detected by carotid intima media thickness (IMT).Background:Oxidative stress and endothelial dysfunction play a critical role in the pathogenesis of atherosclerosis. Dietary vitamin C appears to have anti-oxidant properties and beneficial relations to endothelial function, yet vitamin C taken as a vitamin supplement does not appear to protect from cardiovascular events. The impact of vitamin c intake from supplements vs food on progression of atherosclerosis is unknown.Methods:We examined 3-year progression of carotid IMT in a randomly sampled cohort of 573 healthy women and men aged 40-60 years. Progression of carotid IMT was determined bilaterally with B-mode ultrasound at 3 examinations (1.5-year intervals). Intake of dietary vitamin C was measured by six, 24-hour recall interviews. Intake of vitamin C from vitamin supplements was measured by questionnaire in quartiles of supplement intake and no supplement. Vitamin C wasmeasured in plasma as ascorbic acid.Results:Carotid IMT progressed 10.0±16.5 μm/year (mean±SD) among all those with follow-up (n=500; 87%). For those who took vitamin C supplements, carotid IMT progression increased with dose (p-trend=0.0009). Among persons in the highest quartile (857-5000 mg/day) of vitamin C supplement intake compared to those not consuming any vitamin C supplements, carotid IMT progression increased three-fold (20.3±2.6 versus 7.6±1.8 μm/year (mean±SD); p<0.001). The adverse association of vitamin C supplement intake with carotid IMT was two-fold greater in the upper tertile of serum cholesterol compared to the lower two tertiles (p=0.01). In contrast to the adverse association of vitamin C supplements, vitamin C intake from food had a weak protective relationship on carotid IMT progression (reduced progression -5.0±1.9 μm/year; p=0.008).Conclusions:Vitamin C supplementation is associated with accelerated early atherosclerosis measured by carotid IMT compared to a protective association with vitamin C from food. Theadverse association of vitamin C supplementation may be greater in patients with higher serum cholesterol levels. The current results provide a potential mechanistic understanding for the observed differences between Vitamin C in supplements vs food in prior studies. Given these observations,vitamin C supplementation does not appear to be currently advisable for prevention or treatment of atherosclerosis.

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