scholarly journals A STUDY ON ANTIBIOTIC SUSCEPTIBILITY PATTERN OF ESCHERICHIA COLI ISOLATES FROM EXTRA INTESTINAL INFECTIONS IN A TERTIARY CARE HOSPITAL

2021 ◽  
Vol 9 (11) ◽  
pp. 781-788
Author(s):  
N. Sudha ◽  
◽  
Dillirani V. ◽  
Sheeba V. ◽  
Fahad Affan ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Susceptibility ◽  
Bacterial Infections ◽  
Tertiary Care ◽  
Clinical Samples ◽  
Care Hospital ◽  
Susceptibility Pattern ◽  
Beta Lactam ◽  
Antibiotic Susceptibility Pattern ◽  
Tract Infections

Escherichia coli (E.coli), a common human intestinal commensal causes infections in bodily sites outside the gastrointestinal tract and are called Extra-intestinal pathogenic E.coli. ExPEC causes Urinary tract infections, Blood stream infections, Pneumonia, meningitis,bone, skin, and soft tissue infections including both nosocomial and community acquired infections. The increasing trend of developing antibiotic resistance in ExPEC is of global treat which causes increasing morbidity and mortality.As there is no vaccination forExPEC so it is necessary to analyze the antibiotic susceptibility pattern for empirical treatment in emergency situations.Extended spectrum beta lactamases (ESBLs) hydrolyze β-lactam antibiotics of third generation Cephalosporins, Penicillins and Monobactams. Since the ESBL enzyme genes are usually found in large plasmids, they also contain other antimicrobial resistant genes.AmpC production in E.coli is through plasmids and mutation in their porin structure. Carbapenems are the drug of choice for ESBL producing Ecoli but recent time development of resistance is increasingly reported due to production of Carbapenemase.The aim of this study is to test the Antimicrobial susceptibility pattern of Extra-intestinal Ecoli isolates. The study was conducted in the department of Microbiology, Stanley Medical College, Chennai during the period October 2018 to May 2019.The institutional ethical committee approval was obtained and clinical samples such as urine, blood, pus, sputum and sterile body fluids were received from 983 patients suspected of bacterial infections. The samples were processed and biochemical test identified 84 Ecoli Isolates. Antimicrobial testing, ESBL, AMPC screening and carbapenemase production were tested. E.coli isolates showed resistance to most of the beta lactam antibiotics such as Ampicillin, CefotaximeandCeftazidime and also to Ciprofloxacin &Cotrimoxazole.

scholarly journals Prevalence and antibiotic susceptibility pattern of Klebsiella species isolated from various clinical samples in a tertiary care hospital Coimbatore

2021 ◽  
Vol 8 (10) ◽  
pp. 4886
Author(s):  
Vijayashree V. ◽  
Saikeerthana D. ◽  
Prabha P.
Keyword(s):  
Antibiotic Susceptibility ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Clinical Samples ◽  
Care Hospital ◽  
Susceptibility Pattern ◽  
Klebsiella Species ◽  
Antibiotic Susceptibility Pattern ◽  
Sensitivity Pattern

Background: The genus Klebsiella of Enterobacteriaceae family is ubiquitous in nature. They cause many nosocomial infections like pneumonia, urinary tract infections, wound infections, bacteremia and septicemia. Multidrug resistance is seen in Klebsiella which serves as the most common cause of increased morbidity and mortality. This study reveals the prevalence and antibiotic sensitivity pattern of Klebsiella species from various clinical samples. The primary objectives are as follows: To isolate and characterize Klebsiella species from various clinical samples. To study the antibiotic susceptibility pattern of Klebsiella isolates.Methods: This prospective study was conducted in our tertiary care hospital during the period from August 2019 to October 2019. A total of 3521 samples were tested during this period. The samples include blood, sputum, urine, and pus.Results: Out of the total samples tested,1106 samples were showing the growth of the organisms. Among this,351 were identified as Klebsiella species and the highest rate of isolation of Klebsiella species is from the sputum sample and also the same was reported high in medical wards. The study also shows that the isolation of Klebsiella species shows male preponderance when compared to females. The antibiotic sensitivity pattern was done by Kirby-Bauer's disc diffusion method and the sensitivity was noted to be higher to amikacin and ciprofloxacin.Conclusions: Thus, this study shows the prevalence rate of Klebsiella species and sensitivity pattern of Klebsiella, which may help select appropriate antibiotics and prevent overuse and misuse of antibiotics.

scholarly journals Antibiotic susceptibility pattern of bacteria isolated from patients of respiratory tract infection in a tertiary care hospital of Central India

2017 ◽  
Vol 6 (7) ◽  
pp. 1740
Author(s):  
Shilpi Dhakre ◽  
Pooja Reddy ◽  
Mohit Kulmi ◽  
Chhaya Goyal
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Antibiotic Susceptibility ◽  
Clinical Samples ◽  
Care Hospital ◽  
Susceptibility Pattern ◽  
Antibiotic Susceptibility Pattern ◽  
Tract Infections ◽  
Susceptibility Patterns

Background: Respiratory tract infections are one of the commonest types of infections affecting the Indian population and are a significant cause of morbidity and mortality. To deal with multidrug resistance one should be armed with region specific data about the susceptibility patterns of antimicrobials. This study was planned to identify the common pathogens responsible for the respiratory tract infection and their antibiotic susceptibility patterns.Methods: Smears were prepared from the specimens and gram stains of all clinical samples were done. The organisms were grown on various media and identified according to the standard procedures. The susceptibility patterns of the bacterial pathogens were determined following the panel of antimicrobial agents. Descriptive statistics were used for data analysis.Results: Out of 513 samples 471 samples were further processed. Klebsiella (30.42%) was found to be commonest pathogen followed by Pseudomonas (28.36%). Ampicillin and piperacillin /tazobactam combination were found to be highly efficient against Pseudomonas (83% and 58.8% respectively), E. coli (68% and 50.7% respectively), and Klebsiella (43% and 30.3% respectively). Conclusions: In our study, we found penicillins as the most efficacious antimicrobials to treat respiratory pathogens. The study reveals that the antibiotic susceptibility pattern varies across regions. The prescription of a right antibiotic, for a right patient will help to minimize the menace of emergence of antimicrobial resistance.

scholarly journals Comparison of Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa from Critical and Non-Critical Areas at a Tertiary Care Hospital

2021 ◽  
Vol 8 (12) ◽  
pp. 677-681
Author(s):  
Apoorva B ◽  
Sneha Mohan ◽  
Mukesh Manjhi ◽  
Dalip Kakru
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibiotic Susceptibility ◽  
Tertiary Care ◽  
Clinical Samples ◽  
Care Hospital ◽  
Susceptibility Pattern ◽  
Healthcare Associated Infection ◽  
Antibiotic Susceptibility Pattern ◽  
Critical Areas ◽  
One Year

BACKGROUND Pseudomonas aeruginosa is the most common gram-negative bacterium associated with nosocomial infections. Active observation of changes in antibiotic resistance of Pseudomonas aeruginosa is necessary for the selection of appropriate antimicrobial agent for empirical therapy. This study was conducted to determine the antibiotic susceptibility pattern of Pseudomonas aeruginosa isolated from various clinical samples collected from patients admitted in critical and non-critical areas. METHODS Pseudomonas aeruginosa isolates obtained from various samples in critical and non-critical areas during one-year period were included in the study. The isolates were identified using standard laboratory procedures, and the susceptibility was checked using the Kirby-Bauer disk-diffusion assay according to Clinical and Laboratory Standard Institute (CLSI) guidelines-2019. RESULTS During one-year period, 224 Pseudomonas aeruginosa isolates were isolated from patients admitted to various units, out of which 143 (63.8 %) were from noncritical areas and 81 (36.1 %) were from critical areas. Highest isolation from noncritical area was observed from pus sample 49 (34.26 %) followed by sputum and urine samples 46 (32.16 %) and 27 (16.78 %) respectively. Pseudomonas aeruginosa isolated from critical areas were mainly from endotracheal aspirates 36 (44.4 %) and all were multidrug resistant (MDR) (36.3 %). CONCLUSIONS The present study helps in understanding the emergence of MDR strains in intensive care units (ICUs). Thus, regular surveillance of antibiotic susceptibility pattern is important for reducing the healthcare associated infection (HAI) rates and antimicrobial resistance. KEYWORDS Antibiotic Susceptibility Pattern, Pseudomonas aeruginosa, Critical and Non-Critical Areas

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