scholarly journals EXPRESSION OF MUC2 IN NORMAL GASTRIC MUCOSA, INTESTINAL METAPLASIA AND GASTRIC CARCINOMA BY IMMUNOHISTOCHEMISTRY.

2018 ◽  
Vol 6 (3) ◽  
pp. 1009-1016
Author(s):  
Shuaeb Bhat ◽  
◽  
RP Tania ◽  
Irfan Ansari ◽  
Shaffy Thukral ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Gastric Carcinoma ◽  
Intestinal Metaplasia ◽  
Normal Gastric Mucosa

scholarly journals Expression of MUC5AC in normal gastric mucosa, intestinal metaplasia and gastric carcinoma by immunohistochemistry

2019 ◽  
Vol 7 (4) ◽  
pp. 1282
Author(s):  
Shuaeb Bhat ◽  
Nusrat Bashir ◽  
Showkat Ahmad Mir
Keyword(s):  
Gastric Mucosa ◽  
Gastric Carcinoma ◽  
Intestinal Metaplasia ◽  
Expression Patterns ◽  
P Value ◽  
Normal Gastric Mucosa ◽  
Chi Square ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Chi Square Test

Background: Carcinomas of the stomach are a heterogeneous group of lesions in terms of architecture, pattern of growth, cell differentiation, and histogenesis. Altered MUC5AC expression patterns have been reported previously in intestinal metaplasia as well as in gastric cancer. The aim of the study was to analyse the expression pattern of MUC5AC in normal, pre-neoplastic and neoplastic gastric epithelium.Methods: Formalin fixed paraffin embedded sections of sixty cases which include twenty cases of each normal gastric mucosa, intestinal metaplasia and gastric carcinoma were taken up for the study and subjected to immunohistochemistry using MUC5AC.Results: The intensity of MUC5AC immunostaining in normal gastric mucosa, intestinal metaplasia and gastric carcinoma was evaluated. Immunoreactivity was graded as 0 (negative), ± (trace positive), + (positive) or ++ (strongly positive). Statistical analysis was performed with Chi-Square test and significant differences were noted between these 3 groups (p value <0.05).Conclusions: Authors concluded that MUC5AC expression rates might be good parameters in progression of intestinal metaplasia to gastric carcinoma and might be a good prognostic marker for gastric carcinoma as it is very well implicated in understanding of gastric carcinogenesis.

Immunohistochemical Detection of Carcinoembryonic Antigen (CEA) in Non-Cancerous and Cancerous Gastric Mucosa

1989 ◽  
Vol 4 (1) ◽  
pp. 8-12 ◽  
Author(s):  
A. Nasierowska-Guttmejer ◽  
A.W. Szawlowski
Keyword(s):  
Gastric Mucosa ◽  
Gastric Carcinoma ◽  
Atrophic Gastritis ◽  
Carcinoembryonic Antigen ◽  
Chronic Atrophic Gastritis ◽  
Immunoperoxidase Method ◽  
Immunohistochemical Detection ◽  
Epithelial Hyperplasia ◽  
Normal Gastric Mucosa ◽  
Localization Pattern

Carcinoembryonic antigen (CEA) was stained by the PAP immunoperoxidase method in cancerous and non-cancerous gastric mucosa of 40 patients (25 non-cancerous dyspeptic patients and 15 patients with gastric carcinoma). The pattern of CEA localization was apical or membranous-cytoplasmic and immuno-reactivity was mild (+), moderate (++) or intensive (+++). No CEA immunoreactivity was detected in normal gastric mucosa whereas it was marked in gastric mucosa of non-cancerous dyspeptic patients with chronic atrophic gastritis and dysplasia (intense). In patients with superficial gastritis and epithelial hyperplasia it was mild or absent. The CEA localization pattern was also apical in non-cancerous dyspeptic patients with microscopic changes, e.g. superficial or chronic atrophic gastritis, epithelial hyperplasia and dysplasia, and in non-cancerous mucosa and cancerous tissue of patients with well (G1) and moderately (G2) differentiated adenocarcinoma.

scholarly journals Levels and expressions of orotate phosphoribosyltransferase in gastric carcinoma and normal gastric mucosa tissues

2007 ◽  
Vol 10 (4) ◽  
pp. 234-240 ◽  
Author(s):  
Yoichi Sakurai ◽  
Shingo Kamoshida ◽  
Shinpei Furuta ◽  
Risaburo Sunagawa ◽  
Kazuki Inaba ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Gastric Carcinoma ◽  
Normal Gastric Mucosa ◽  
Orotate Phosphoribosyltransferase

scholarly journals Incomplete Intestinal Metaplasia as an Indicator for Early Detection of Gastric Carcinoma in The Events of Helicobacter Pylori Positive Chronic Atrophic Gastritis

2006 ◽  
Vol 6 (4) ◽  
pp. 48-53 ◽  
Author(s):  
Zora Vukobrat-Bijedić ◽  
Svjetlana Radović ◽  
Azra Husić-Selimović ◽  
Srđan Gornjaković
Keyword(s):  
Gastric Mucosa ◽  
Gastric Carcinoma ◽  
Atrophic Gastritis ◽  
Intestinal Metaplasia ◽  
Risk Group ◽  
Precancerous Lesion ◽  
Chronic Atrophic Gastritis ◽  
Tumor Lesion ◽  
H Pylori ◽  
Lesser Curvature

The aim of the study was to ascertain the existence of intestinal metaplasia in gastric mucosa of patients with gastric carcinoma coupled with H. pylori positive chronic atrophic gastritis and possible connection of IM with the development of gastric carcinoma. The paper presents prospective study that included 50 patients with gastric carcinoma and 50 patients with chronic atrophic H. pylori positive gastritis. All the patients were subjected to gastroscopy as well as biopsy targeted at antrum, lesser curvature and corpus and at the area 1-2 cm removed from tumor lesion. Biopsy samples were sliced by microtome and stained. We analyzed presence, frequency and severity of inflammatory-regenerative, metaplastic and dysplastic changes in the mucosa and evaluated their prognostic value. We typed IM immunohistochemically. This study confirmed responsibility of H. pylori for inflammatory events in gastric mucosa in patients with gastriccarcinoma. According to our findings incomplete IM of types IIa and IIb as precancerous lesion is responsible for the development of gastriccarcinoma and is associated with chronic atrophic gastritis grade I and II (92% of subjects, p=0.0097, h=1, p=0.01). Thus, the finding of incomplete intestinal metaplasia may be used as an indicator for early gastric carcinoma detection. Patients with patho-histologically verified incomplete intestinal metaplasia associated with active chronic atrophic gastritis of levels I and II represent risk group for the development of gastric carcinoma of intestinal type.

Sign in / Sign up

Export Citation Format

Share Document