Curcumin (Curcuma longa) and quercetin nanoparticles as antimicrobial and anticancer agents

doi:10.21608/ajbs.2021.192445

New histone deacetylase inhibitors and anticancer agents from Curcuma longa

Medicinal Chemistry Research ◽

10.1007/s00044-019-02414-5 ◽

2019 ◽

Vol 28 (10) ◽

pp. 1773-1782 ◽

Cited By ~ 1

Author(s):

Pakit Kumboonma ◽

Thanaset Senawong ◽

Somprasong Saenglee ◽

Gulsiri Senawong ◽

La-or Somsakeesit ◽

...

Keyword(s):

Histone Deacetylase ◽

Anticancer Agents ◽

Histone Deacetylase Inhibitors ◽

Curcuma Longa

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Natural Products as Anticancer Agents

Current Drug Targets ◽

10.2174/1389450121999201230204526 ◽

2020 ◽

Vol 22 ◽

Author(s):

Ruby Varghese ◽

Yogesh Bharat. Dalvi

Keyword(s):

Natural Products ◽

Anticancer Agents ◽

Cancer Metastasis ◽

Kinase Inhibitor ◽

Curcuma Longa ◽

Aloe Vera ◽

Angiogenesis Inhibitor ◽

Cancer Therapeutics ◽

Free Radical Scavenger ◽

Radical Scavenger

Abstract:: Medicinal plants and mushrooms have alwaysfascinated the world as an attractive source of natural compounds for cancer therapy. From ancient times, they have been valued as gourmet food and folk medicine in Oriental practice. For over 40 years, world has witnessed the overwhelming interest of western scientific fraternity in pharmaceutical potential of natural products in combating cancer. The plants and mushrooms credited with success against angiogenesis and cancer metastasis belong to certain Plants including Catharanthus roseus, Aloe Vera,Annona muricata,Curcuma longa, Withania somnifera, and Berberis and mushrooms such as Agaricus,Antrodia,Ganoderma,Grifolafrondosa,Hericiumerinaceus,Phel-linuslinteus, and Trametesversicolor /Coriolusversicolor. The anti-cancer compounds play a pivotal role as free radical scavenger and reactive oxygen species inducer, mitotic spindle kinase inhibitor, anti-mitotic, angiogenesis inhibitor, topoi-somerase inhibitor, apoptosis inducers, and eventually checking cancer invasion, migration and proliferation. The present review updates and focuses on the recent findings of the pharmacologically potential bioactive compounds, their anti-tumor potential, and underlying mechanism of preventing cancer metastasis and angiogenesisin order to raise knowledge for fur-ther investigations to develop cancer therapeutics with no adverse side effects The mounting experimental evidences at pre-clinical and clinical levels from various research groups across the globe, regarding prevention of cancer metastasis by natural products unarguably make it a fast-track research area worth mass attention.

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A Review of Curcumin and Its Derivatives as Anticancer Agents

International Journal of Molecular Sciences ◽

10.3390/ijms20051033 ◽

2019 ◽

Vol 20 (5) ◽

pp. 1033 ◽

Cited By ~ 83

Author(s):

Mhd Tomeh ◽

Roja Hadianamrei ◽

Xiubo Zhao

Keyword(s):

Anticancer Agents ◽

Anticancer Agent ◽

Human Subjects ◽

Curcuma Longa ◽

Treatment Strategies ◽

Mortality Rates ◽

Mechanisms Of Action ◽

Cellular Targets ◽

The Past ◽

Incidence And Mortality

Cancer is the second leading cause of death in the world and one of the major public health problems. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Curcumin, the active ingredient of the Curcuma longa plant, has received great attention over the past two decades as an antioxidant, anti-inflammatory, and anticancer agent. In this review, a summary of the medicinal chemistry and pharmacology of curcumin and its derivatives in regard to anticancer activity, their main mechanisms of action, and cellular targets has been provided based on the literature data from the experimental and clinical evaluation of curcumin in cancer cell lines, animal models, and human subjects. In addition, the recent advances in the drug delivery systems for curcumin delivery to cancer cells have been highlighted.

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Curcumin and Its Derivatives as Potential Therapeutic Agents in Prostate, Colon and Breast Cancers

Molecules ◽

10.3390/molecules24234386 ◽

2019 ◽

Vol 24 (23) ◽

pp. 4386 ◽

Cited By ~ 14

Author(s):

Zintle Mbese ◽

Vuyolwethu Khwaza ◽

Blessing Atim Aderibigbe

Keyword(s):

Anticancer Agents ◽

Clinical Medicine ◽

Curcuma Longa ◽

Breast Cancers ◽

Anticancer Activities ◽

Curcumin Derivatives ◽

Cycle Arrest ◽

Life Threatening ◽

Proliferation And Metastasis ◽

Poor Absorption

Cancer is a life-threatening disease and is the second leading cause of death around the world. The increasing threats of drug-resistant cancers indicate that there is an urgent need for the improvement or development of more effective anticancer agents. Curcumin, a phenolic compound originally derived from turmeric plant (Curcuma longa L. (Zingiberaceae family)) widely known as a spice and a coloring agent for food have been reported to possess notable anticancer activity by inhibiting the proliferation and metastasis, and enhancing cell cycle arrest or apoptosis in various cancer cells. In spite of all these benefits, the therapeutic application of curcumin in clinical medicine and its bioavailability are still limited due to its poor absorption and rapid metabolism. Structural modification of curcumin through the synthesis of curcumin-based derivatives is a potential approach to overcome the above limitations. Curcumin derivatives can overcome the disadvantages of curcumin while enhancing the overall efficacy and hindering drug resistance. This article reports a review of published curcumin derivatives and their enhanced anticancer activities.

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