INTRODUCTION: Menopause is a normal, natural event, defined as the final menstrual period (FMP). Women now spend one third to one half of their lives after menopause. Women who underwent natural menopause before age 45 years had an increased risk of thyroid dysfunction, diabetes, hypertension, obesity and dyslipidemia which are considered as risk factors for ischemic heart disease.
METHODOLOGY: 50 early menopausal women attending the outpatient and inpatient departments of DR.B.R. Ambedkar Medical College and Hospital, were randomly included in this study. All the patients are subjected to detailed history regarding demographic data, general physical examination (including vitals, weight, height, BMI). Investigations like Thyroid profile (T3,T4,TSH), Fasting Lipid Profile, ECG were done.
RESULTS: Study patients were found to be in 40-70 years age group, with maximum number of patients in 40-50 years group. Mean age of menopause is 42.34±1.92. Among the studied population 27(54%) patients had thyroid dysfunction. All 27 patients had hypothyroidism, 3(13%) patients had subclinical hypothyroidism upon evaluation and rest of the patients were euthyroid. TSH was found to be higher 6.50±4.87 among the studied patients and was found to be statistically associated with thyroid disorders. In studied subjects 19(38%) had dyslipidemia, 1 patient had borderline and rest 30 patients had normal lipid profile. 17(34%) of studied patients had ischemic heart disease. Among the 17 patients having IHD, 10(58.82%) patients were hypothyroid, 15(88.23%) patients had hypertension and 10 (52.63%) had dyslipidemia. Amongst the studied subjects 33(66%) patients were overweight and 9(18%) patients were obese according to BMI.
CONCLUSION: Significant number of early menopausal women in this study have hypertension, thyroid dysfunction, dyslipidemia and high BMI which are considered as risk factors for coronary artery disease. Hence screening can be recommended for early menopausal women for thyroid dysfunction, especially in those with increasing age , duration of menopause and overweight women to evaluate and correct dyslipidemia so as to prevent adverse atherosclerotic cardiovascular complications and to prevent morbidity and mortality.