scholarly journals ASSESSING THE EFFECTS OF ORLISTAT AS AN ANTI-OBESITY DRUG IN HIGH FAT DIET INDUCED OBESITY IN MALE RATS

2021 ◽  
Vol 44 (1) ◽  
pp. 131-138
Author(s):  
Enas Abdel-Baky ◽  
Omnia Abdel-Rahman
Keyword(s):  
High Fat Diet ◽  
Male Rats ◽  
High Fat ◽  
Diet Induced Obesity

scholarly journals Reversal of Diet-Induced Obesity Increases Insulin Transport into Cerebrospinal Fluid and Restores Sensitivity to the Anorexic Action of Central Insulin in Male Rats

Endocrinology ◽  
2013 ◽  
Vol 154 (3) ◽  
pp. 1047-1054 ◽  
Author(s):  
Denovan P. Begg ◽  
Joram D. Mul ◽  
Min Liu ◽  
Brianne M. Reedy ◽  
David A. D'Alessio ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Food Intake ◽  
High Fat Diet ◽  
Male Rats ◽  
Control Group ◽  
Chow Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Insulin Transport ◽  
The Central Nervous System

Abstract Diet-induced obesity (DIO) reduces the ability of centrally administered insulin to reduce feeding behavior and also reduces the transport of insulin from the periphery to the central nervous system (CNS). The current study was designed to determine whether reversal of high-fat DIO restores the anorexic efficacy of central insulin and whether this is accompanied by restoration of the compromised insulin transport. Adult male Long-Evans rats were initially maintained on either a low-fat chow diet (LFD) or a high-fat diet (HFD). After 22 weeks, half of the animals on the HFD were changed to the LFD, whereas the other half continued on the HFD for an additional 8 weeks, such that there were 3 groups: 1) a LFD control group (Con; n = 18), 2) a HFD-fed, DIO group (n = 17), and 3) a HFD to LFD, DIO-reversal group (DIO-rev; n = 18). The DIO reversal resulted in a significant reduction of body weight and epididymal fat weight relative to the DIO group. Acute central insulin administration (8 mU) reduced food intake and caused weight loss in Con and DIO-rev but not DIO rats. Fasting cerebrospinal fluid insulin was higher in DIO than Con animals. However, after a peripheral bolus injection of insulin, cerebrospinal fluid insulin increased in Con and DIO-rev rats but not in the DIO group. These data provide support for previous reports that DIO inhibits both the central effects of insulin and insulin's transport to the CNS. Importantly, DIO-rev restored sensitivity to the effects of central insulin on food intake and insulin transport into the CNS.

Chronic administration of Norwegian Ascophyllum nodosum phytocomplex inhibits high-fat-diet-induced obesity in male rats

Nutrafoods ◽  
2014 ◽  
Vol 13 (3) ◽  
pp. 113-122
Author(s):  
Stefania Murzilli ◽  
Donata Di Tommaso ◽  
Vincenzo Di Matteo ◽  
Luisa Sciulli ◽  
Daniela Corna ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Chronic Administration ◽  
Ascophyllum Nodosum ◽  
Male Rats ◽  
High Fat ◽  
Diet Induced Obesity

scholarly journals OR-006 Effect of Moderate-intensity Exercise on the Expression of Hypothalamic KiSS-1 and GPR54 mRNA in Diet Induced Obesity Rats

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Yi Yan ◽  
Chunyu Liang ◽  
Rui Xu
Keyword(s):  
High Fat Diet ◽  
Normal Diet ◽  
Treadmill Training ◽  
Male Rats ◽  
Moderate Intensity ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Diet Induced Obesity ◽  
Sd Rats ◽  
Fat Feeding

Objective To observe the effect of high fat diet on the hypothalamic expression of KiSS-1and the G-protein coupled receptor (GPR) 54 mRNA and explore the modulatory role of moderate-intensity exercise in the diet induced obesity male rats. Methods After 8 weeks high fat feeding, 20 obesity 11-weeks SD rats were randomly assigned to high-fat diet sedentary (FS, n=8) and high-fat diet exercise (FE, n=8) groups, 20 normal diet 11-weeks SD rats also were randomly assigned to sedentary (SS, n=8) and exercise (SE, n=8) groups. During the following 8 weeks, obesity rats were continued expose to high-fat-diet. SE and FE groups did the 60%-70%V(•)O2max treadmill training (5 days/week, 1 hour/day). The V(•)O2 max of exercise groups were remeasured every two weeks. The hypothalamic expression of KiSS-1 and GPR54 mRNA were tested in each group. Results After the first 8-weeks high fat feeding, the obesity rats were heavier than normal diet group (491.74±26.19g vs. 410.05±45.77g, p<0.01). After 8-weeks training, the FE group was lighter than FS group (590.23±35.74g vs. 681±52.56, p<0.01). The FS group had higher hypothalamic expression of KiSS-1 mRNA (1.51±0.66 vs 0.75±0.27, p<0.05) and GPR54 mRNA (2.45±0.38 vs 0.61±0.15, p<0.01) than SS group. The FE group had lower hypothalamic expression of KiSS-1 mRNA (0.69±0.13, p>0.05) and GPR54 mRNA (0.58±0.10, p<0.01) than FS group. Conclusions There is stimulating effect of high-fat diet induced obesity on hypothalamic expression of KiSS-1and GPR54 mRNA. 8-weeks 60%-70%V (•) O2max treadmill training could cure this effect.  

scholarly journals Genetically Inherited Obesity and High-Fat Diet–Induced Obesity Differentially Alter Spermatogenesis in Adult Male Rats

Endocrinology ◽  
2018 ◽  
Vol 160 (1) ◽  
pp. 220-234 ◽  
Author(s):  
Sharvari S Deshpande ◽  
Harishankar Nemani ◽  
Suresh Pothani ◽  
Kushaan Khambata ◽  
Anita Kumar ◽  
...  
Keyword(s):  
Adult Male ◽  
High Fat Diet ◽  
Male Rats ◽  
High Fat ◽  
Diet Induced Obesity

Effect of Vitamin E Supplementation on Oxidative Stress in a Rat Model of Diet-induced Obesity

2009 ◽  
Vol 79 (4) ◽  
pp. 255-263 ◽  
Author(s):  
XiuHua Shen ◽  
QingYa Tang ◽  
Jiang Wu ◽  
Yi Feng ◽  
Juan Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Glucose Metabolism ◽  
Plasma Glucose ◽  
High Fat Diet ◽  
Intervention Group ◽  
Male Rats ◽  
Control Group ◽  
High Fat ◽  
Diet Induced Obesity

Objective: To evaluate the effect of vitamin E on the level of oxidative stress in diet-induced obese Sprague-Dawley rats. Methods: Thirty weaning male rats were placed into three groups with 10 animals each: a control group with normal chow, a diet-induced obesity group (DIO) with high-fat diet, and an intervention group with high-fat diet supplemented with vitamin E (VE, 350 mg/kg). Blood and adipose tissue were collected from rats after 10 weeks. Biomarkers of oxidative stress were detected for plasma 8-epi-prostaglandin- F2α (8-epi-PGF2α), thiobarbituric acid-reactive substances (TBARS), total anti-oxidative capacity (TAOC), α-tocopherol, superoxide dismutase (SOD) activity, and glutathione peroxidase activity (GPx). Lipid and glucose metabolism parameters such as plasma glucose, insulin, and triacylglycerol (TG) were also analyzed. Results: After 10 weeks, all obese rats (both the DIO and VE groups) had higher plasma 8-epi-PGF2α and TBARS levels than the controls. Their plasma-adjusted α-tocopherol, SOD, and GPx activities were lower than the control levels but insulin was higher (p<0.01). The VE intervention increased plasma SOD, GPx, and T-AOC, and decreased 8-epi-PGF2α (p<0.05). VE intervention also decreased plasma glucose, insulin, and TG levels (p<0.05). Conclusions: Increased oxidative stress could be an important target for the prevention of obesity-related diseases. Vitamin E has moderate effects for improvement of oxidative stress status and glucose metabolism in the animal model of diet-induced obesity.

scholarly journals Cafeteria diet increased adiposity in comparison to high fat diet in young male rats

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6656 ◽  
Author(s):  
Yucel Buyukdere ◽  
Atila Gulec ◽  
Asli Akyol
Keyword(s):  
High Fat Diet ◽  
Dietary Intervention ◽  
Young Male ◽  
Cafeteria Diet ◽  
Male Rats ◽  
Chow Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Total Body ◽  
Fat Depot

Background Dietary intervention studies in animal models of obesity are crucial to elucidate the mechanistic effects of specific nutrients and diets. Although several models of diet induced obesity have been examined in rodents to assess obesity, there are few studies that have researched influence of different high fat and/or westernized diets. The aim of this study was to compare a high fat diet and a cafeteria diet on obesity related biochemical and physiological parameters in young male rats. Methods Five week old Wistar male rats were fed a control chow diet (C), butter-based high fat diet (HF) or cafeteria diet (CAF) for twelve weeks. In HF, 40% of energy came from fat and this ratio was 46% in CAF. CAF composed of highly energetic and palatable human foods along with chow diet. At the end of the feeding protocol all animals were culled using CO2 asphyxia and cervical dislocation after an overnight fasting. Results Total energy and fat intake of CAF was significantly higher than C and HF. CAF was more effective in inducing obesity, as demonstrated by increased weight gain, Lee index, fat depot weights and total body fat in comparison to C and HF. Despite increased adiposity in CAF, plasma glucose, insulin and HOMA-IR levels were similar between the groups. Plasma leptin and cholesterol levels were markedly higher in CAF than C and HF. Discussion We have demonstrated that there are differential effects of high fat diet and cafeteria diet upon obesity and obesity-related parameters, with CAF leading to a more pronounced adiposity in comparison to high fat diet in young male rats. Future studies should consider the varied outcomes of different diet induced obesity models and development of a standardized approach in similar research practices.

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