Synthesis and Characterization Of Dextran Coated Magnetite Nanoparticles Loaded With Curcumin And In Vitro Cytotoxicity Study In MCF-7 Cancer Cells

2017 ◽  
Vol 33 (2) ◽  
pp. 365-374
Author(s):  
Omayma Abouzaid ◽  
Omama El Shawi ◽  
Nahla Mansour ◽  
Aml Hanafy
Keyword(s):  
Cancer Cells ◽  
Magnetite Nanoparticles ◽  
In Vitro Cytotoxicity ◽  
Synthesis And Characterization ◽  
Mcf 7

Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

2019 ◽  
Vol 37 (11) ◽  
pp. 1183-1187 ◽  
Author(s):  
Ha Thi Phuong ◽  
Tran Thu Huong ◽  
Le Thi Vinh ◽  
Hoang Thi Khuyen ◽  
Do Thi Thao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Folic Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Synthesis And Characterization ◽  
Mcf 7

Synthesis and characterization of benzotriazolyl acrylonitrile analogs-based donor-acceptor molecules: optical properties, in vitro cytotoxicity, and cellular imaging

2021 ◽  
pp. 109251
Author(s):  
Eugenio Hernández-Fernández ◽  
Ana Sofia Ortega-Villarreal ◽  
Ma. Concepción García-López ◽  
Rodrigo Chan-Navarro ◽  
Samuel Garrard ◽  
...  
Keyword(s):  
Optical Properties ◽  
Cellular Imaging ◽  
In Vitro Cytotoxicity ◽  
Synthesis And Characterization ◽  
Donor Acceptor ◽  
Acceptor Molecules

scholarly journals FORMULATION AND CHARACTERIZATION OF CYCLODEXTRIN BASED CURCUMIN LOADED NANOSPONGE

2022 ◽  
pp. 130-138
Author(s):  
ANUP M. AKARTE ◽  
PRAKASH H. PATIL
Keyword(s):  
Melting Point ◽  
Breast Cancer Cells ◽  
Combination Index ◽  
In Vitro Cytotoxicity ◽  
Index Analysis ◽  
Ic50 Value ◽  
Poorly Soluble ◽  
Mcf 7

Objective: The aim of proposed work is to develop and screen cyclodextrin based Nanosponge loaded with poorly soluble anticancer drug and to optimize most suitable Nanosystem with increased solubility and dissolution rate. Methods: Cyclodextrinnanosponge (CDNS) was prepared using pyromelliticdianhydride as a crosslinker for beta cyclodextrin monomer. Cyclodextrinnanosponge and curcumin were taken in 1:1 w/w proportion. The resultant curcumin loaded nanosponges were dried at 50±0.5 °C for 24 h. Results: The absorbance maxima for Curcumin was seen at 424.0 nm and for cyclodextrin was seen at 290.0 nm, The average melting point of pure drug is 181 °C which is complies with Stander melting point of drug and the aspect ratio of the nanosponge was found 1.037. Zeta potential noticed for CUR-CD-NS were more negative contrasted with separate plain CUR (−20.1±1.57) demonstrating solidness of the nanodispersion. Curcumin release from CUR-CDNS was upgraded to very nearly 10 folds toward the finish of 8 hour. Treatment with a combination of CUR-CDNS at 1:1 and 1:3 ratios resulted in an IC50 value was found 14.98 μg/ml. Conclusion: In vitro cytotoxicity study and combination index analysis showed the synergistic effect of CUR-CDNS against MCF-7 cells. The present study reveals that the combination of curcumin results in higher cytotoxicity against breast cancer cells.

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