Interleukin-5, Interleukin-6 and Eosinophils in COVID-19 Egyptian Patients: Potential Clues for Prognosis and Immunotherapy

Interleukin-10 (IL-10) and interleukin-6 (IL-6) have been reported to be related to hepatocellular carcinoma (HCC) prognosis. This study aimed to investigate the clinical usefulness of serum levels of IL-6 and IL-10 as biomarkers for HCC among high-risk patients. Materials and Methods. 80 individuals were enrolled in this study; they were categorized into 4 groups: group 1 healthy individuals (NC) (n=20), group 2 chronic hepatitis C virus (HCV) patients (n=20), group 3 cirrhotic patients (LC) (n=20), and HCC group (n=20). Using ELISA technique serum levels of IL-6, IL-10, and alpha fetoprotein (AFP) were evaluated in all groups. Results. The mean serum levels of IL-6 were significantly higher in HCC than in LC, HCV, and NC groups (13.99±1.80, 7.49±0.43, 5.78±0.74, and 2.57±0.31), respectively (P<0.05); also the serum levels of IL-10 were significantly higher in HCC compared with LC, HCV, and NC groups (13.69±1.89, 7.37±0.53, 5.18±0.6, and 3.31±0.42) (P<0.05). We also found that the tumor size is correlated strongly with IL-6 and IL-10 levels (r=0.925, P<0.001; r=0.821, P<0.001), respectively. Conclusion. The combination of those markers may help to identify a group of HCC patients with low AFP.

Download Full-text

Can brain natriuretic peptide, S100b, and interleukin-6 prognosticate the neurological consequences in Egyptian patients presented with supratentorial intracerebral hemorrhage?

Surgical Neurology International ◽

10.25259/sni_784_2020 ◽

2020 ◽

Vol 11 ◽

pp. 460

Author(s):

Hany A. Fikry Eldawoody ◽

Mohammed Abdel Bari Mattar ◽

Abeer Mesbah ◽

Ashraf Zaher ◽

Mohammed Elsherif

Keyword(s):

Intracerebral Hemorrhage ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Interleukin 6 ◽

Calcium Binding ◽

Length Of Hospital Stay ◽

Serum Levels ◽

Severity Scores ◽

Egyptian Patients ◽

Ich Score

Background: Biomarkers in supratentorial intracerebral hemorrhage (SICH) enhance the prognosis of the disease. This study aimed to assess the prognosticative grade of S100 calcium-binding protein B (S100B), interleukin-6 (IL-6), and the pro-brain natriuretic peptide (pro-BNP) in SICH outcome prediction. Methods: Blood samples of 50 SICH patients were analyzed for the biomarkers. The patients were classified into two groups with and without intraventricular hemorrhage (IVH). The following scales including Glasgow Coma Score (GCS), the Barthel index (BI), intracerebral hemorrhage (ICH) score, ICH volume, National Institutes of Health Stroke Scale (NIHSS), Modified Rankin Score (mRS), and length of stay were used to evaluate the severity. Results: The severity scores (NIHSS, GCS, BI, mRI) were significantly higher in SICH patients with IVH versus SICH patients without IVH (P = 0.002, 0.008, 0.001, and 0.03, respectively). Serum levels for a pro-BNP and S100b are significantly higher in SICH patients with IVH versus SICH patients without IVH (P = 0.02 and 0.027, respectively). Multivariate correlations between demographic (age), biomarkers panel (IL-6, S100b, and proBNP), and clinical and severity scores (ICH score, ICH volume, length of hospital stay [LOS], BI, mRS, GCS, and NIHSSS) in all studied patients showed a highly significant correlation between ICH score and pro-BNP (P = 0.04). There was a highly significant correlation between LOS and IL-6 (P = 0.003). Conclusion: Pro-BNP, IL-6, and S100b are greatly associated with the presence of IVH that, in turn, correlated well with poor clinical outcome measures.

Download Full-text