ARTESUNATE COMBINED WITH PRAZIQUANTEL THERAPY MODULATE THE ANTIBODY RESPONSE IN MURINE SCHISTOSOMIASIS MANSONI

Antibody response to Salmonella typhi O and H antigens was evaluated in 24 individuals with either hepatointestinal or hepatosplenic schistosomiasis mansoni before and after typhoid vaccination, and compared with that of non-infected controls. Before vaccination, Schistosoma-infected patients showed a higher frequency of positive antibody to O antigen and the same frequency to H antigen when compared with that of healthy individuals. However, those with hepatosplenic schistosomiasis showed higher titres of antibody to H antigen than those with hepatointestinal disease or healthy individuals. Infected subjects, particularly those with hepatointestinal disease, showed a decreased response after typhoid vaccine. Tins diminished ability to mount an immune response towards typhoid antigens dining schistosomiasis may interfere ivith the clearance of the bacteria from blood stream and, therefore, play a role in the prolonged survival of salmonella as obsewed in some patients with chronic salmonellosis associated with schistosomiasis.

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The inheritance of responses to schistosomiasis mansoni in two pairs of inbred strains of mice

Parasitology ◽

10.1017/s003118200005099x ◽

1985 ◽

Vol 90 (2) ◽

pp. 289-300 ◽

Cited By ~ 5

Author(s):

Janet T. Jones ◽

J. R. Kusel

Keyword(s):

Antibody Response ◽

Parental Strain ◽

Genetic Factors ◽

Single Gene ◽

Inbred Strains ◽

Bimodal Distribution ◽

Immunological Responses ◽

Schistosomiasis Mansoni ◽

Inbred Strains Of Mice ◽

Hybrid Mice

Genetic differences in mice influence both the pathological and immunological responses to schistosomiasis mansoni. We have investigated the nature of the genetic factors influencing these responses by crossing two different pairs of strains of mice which vary in their response to infection, and measuring responses in the F1hybrid and backcross offspring. The two pairs of parental strains differed with respect to faecal egg excretion, accumulation of eggs in the tissues, splenomegaly and pattern of antibody response. The numbers of adult worms which establish do not differ between strains. The inheritance of the responses measured was different in the two pairs of strains. The F1hybrid from the C57BL/6/Ol/a /c cross resembled the low-responding parental strain (CBA/Ca) with respect to faecal egg excretion, accumulation of eggs in the tissues and splenomegaly, and was intermediate in its pattern of antibody response. The F1hybrid mice from the NIH /Ca cross resembled the high-responding strain (CBA/Ca) with respect to faecal egg excretion, accumulation of eggs in the tissues and splenomegaly, and had an earlier and greater antibody response than either parental strain. No evidence of single gene influence on any of these responses was seen in the backcross offspring. The differing patterns of inheritance and the absence of a bimodal distribution of responses in the backcross offspring indicate that each of these responses is influenced by multiple genes. The pattern of antibody response did not correlate between strains with any of the pathological res The positive correlation of egg accumulation in the tissues and faecal egg excretion suggests that there are genetic influences on the fecundity of the worms.

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The influence of the H-2 complex on responses to infection by Schistosoma mansoni in mice

Parasitology ◽

10.1017/s0031182000057139 ◽

1983 ◽

Vol 86 (1) ◽

pp. 19-30 ◽

Cited By ~ 15

Author(s):

Janet T. Jones ◽

D. M. Mccaffery ◽

J. R. Kusel

Keyword(s):

Major Histocompatibility Complex ◽

Antibody Response ◽

Schistosoma Mansoni ◽

Genetic Background ◽

Worm Burden ◽

Major Effect ◽

Schistosomiasis Mansoni ◽

Histocompatibility Complex ◽

Faecal Egg Count ◽

Antibody Titres

SUMMARYIn order to determine whether a given H-2 haplotype has similar effects on responses to schistosomiasis mansoni on different genetic backgrounds, mice of 2 pairs of congenic strains (H-2b and H-2k on BALB/c and C57BL/10 backgrounds) were infected. Worm burdens, mortality, splenomegaly, tissue and faecal egg counts, and antibody titres to worm and egg antigens were measured. The genetic background had a major effect on the genesis of splenomegaly, on the deposition of eggs in the spleen, the maximum faecal egg count, the antibody titre to egg and worm antigens and the rate of generation of antibody response. The H-2 haplotype was shown to consistently influence the maximum faecal egg count and the antibody titres. Worm burden was not influenced by genetic differences between strains and mortality differences were not significant. The data presented here indicate that the effect of the major histocompatibility complex on responses to infection is greatly influenced by the genetic background on which it is expressed.

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