The association between Uncoupling proteins (UCP2) gene expression and obesity.

Uncoupling proteins (UCPs) are mitochondrial membrane transporters involved in the control of energy conversion in mitochondria. Experimental and genetic evidence relate dysfunctions of UCPs with metabolic syndrome and obesity. The PPAR subtypes mediate to a large extent the transcriptional regulation of the UCP genes, with a distinct relevance depending on the UCP gene and the tissue in which it is expressed. UCP1 gene is under the dual control of PPARγand PPARαin relation to brown adipocyte differentiation and lipid oxidation, respectively. UCP3 gene is regulated by PPARαand PPARδin the muscle, heart, and adipose tissues. UCP2 gene is also under the control of PPARs even in tissues in which it is the predominantly expressed UCP (eg, the pancreas and liver). This review summarizes the current understanding of the role of PPARs in UCPs gene expression in normal conditions and also in the context of type-2 diabetes or obesity.

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Skeletal muscle UCP3 and UCP2 gene expression in response to inhibition of free fatty acid flux through mitochondrial β-oxidation

Pflügers Archiv - European Journal of Physiology ◽

10.1007/s004240051061 ◽

1999 ◽

Vol 438 (4) ◽

pp. 452-457 ◽

Cited By ~ 18

Author(s):

S. Samec ◽

J. Seydoux ◽

A.G. Dulloo

Keyword(s):

Gene Expression ◽

Skeletal Muscle ◽

Fatty Acid ◽

Free Fatty Acid ◽

Ucp2 Gene

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Induction of UCP2 Gene Expression by LPS: A Potential Mechanism for Increased Thermogenesis during Infection

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.1998.8219 ◽

1998 ◽

Vol 244 (1) ◽

pp. 75-78 ◽

Cited By ~ 54

Author(s):

Raffaella Faggioni ◽

Judy Shigenaga ◽

Arthur Moser ◽

Kenneth R. Feingold ◽

Carl Grunfeld

Keyword(s):

Gene Expression ◽

Potential Mechanism ◽

Ucp2 Gene

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Uncoupling protein-2 (UCP2) gene expression in subcutaneous and omental adipose tissue of Asian Indians

Adipocyte ◽

10.4161/adip.19671 ◽

2012 ◽

Vol 1 (2) ◽

pp. 101-107 ◽

Cited By ~ 16

Author(s):

Sujata R. Mahadik ◽

Ramchandra D. Lele ◽

Dhananjaya Saranath ◽

Anika Seth ◽

Vikram Parikh

Keyword(s):

Gene Expression ◽

Adipose Tissue ◽

Asian Indians ◽

Uncoupling Protein ◽

Uncoupling Protein 2 ◽

Omental Adipose Tissue ◽

Ucp2 Gene

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Genetic variants of uncoupling proteins-2 and -3 in relation to maximal oxygen uptake in different sports.

Acta Biochimica Polonica ◽

10.18388/abp.2013_1953 ◽

2013 ◽

Vol 60 (1) ◽

Cited By ~ 3

Author(s):

Joanna Holdys ◽

Piotr Gronek ◽

Jakub Kryściak ◽

Daniel Stanisławski

Keyword(s):

Oxygen Uptake ◽

Maximal Oxygen Uptake ◽

Genetic Variants ◽

Untranslated Region ◽

Heat Energy ◽

Uncoupling Proteins ◽

Atp Production ◽

Ucp3 Gene ◽

Ucp2 Gene ◽

The University

Uncoupling proteins 2 and 3 (UCP2 and UCP3) as mitochondrial electron transporters are involved in regulation of ATP production and energy dissipation as heat. Energy efficiency plays an important role in physical performance, especially in aerobic fitness. The aim of this study was to examine the association between maximal oxygen uptake and genetic variants of the UCP2 and UCP3 genes. The studies were carried out in a group of 154 men and 85 women, professional athletes representing various sports and fitness levels and students of the University of Physical Education in Poznań. Physiological and molecular procedures were used, i.e. direct measurement of maximum oxygen uptake (VO₂max) and analysis of an insertion/deletion (I/D) polymorphism in the 3'untranslated region of exon 8 of the UCP2 gene and a C>T substitution in exon 5 (Y210Y) of the UCP3 gene. No statistically significant associations were found, only certain trends. Insertion allele (I) of the I/D UCP2 and the T allele of the UCP3 gene were favourable in obtaining higher VO₂max level and might be considered as endurance-related alleles.

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