scholarly journals Uncoupling Protein 3 (UCP3) but Not UCP2 Gene Expression Is Increased in the Human Glucose Transporter - 4 Overexpressing Suckling Mice

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 56A-56A
Author(s):  
N K MacLennan ◽  
C D Hart ◽  
R H Lane ◽  
S U Devaskar
Keyword(s):  
Gene Expression ◽  
Glucose Transporter ◽  
Uncoupling Protein ◽  
Glucose Transporter 4 ◽  
Suckling Mice ◽  
Uncoupling Protein 3 ◽  
Ucp2 Gene

scholarly journals Uncoupling protein-2 (UCP2) gene expression in subcutaneous and omental adipose tissue of Asian Indians

Adipocyte ◽  
2012 ◽  
Vol 1 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Sujata R. Mahadik ◽  
Ramchandra D. Lele ◽  
Dhananjaya Saranath ◽  
Anika Seth ◽  
Vikram Parikh
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Asian Indians ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Omental Adipose Tissue ◽  
Ucp2 Gene

scholarly journals Up-Regulation of Uncoupling Protein 3 Gene Expression by Fatty Acids and Agonists for PPARs in L6 Myotubes

Endocrinology ◽  
2001 ◽  
Vol 142 (10) ◽  
pp. 4189-4194 ◽  
Author(s):  
Cheol Son ◽  
Kiminori Hosoda ◽  
Junichi Matsuda ◽  
Junji Fujikura ◽  
Shin Yonemitsu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Uncoupling Protein ◽  
L6 Myotubes ◽  
Uncoupling Protein 3

Effect of moderate exercise immediately followed by induced hyperglycemia on gene expression and content of the glucose transporter-4 protein in skeletal muscles of horses

2003 ◽  
Vol 64 (11) ◽  
pp. 1401-1408 ◽  
Author(s):  
Yvette S. Nout ◽  
Kenneth W. Hinchcliff ◽  
Edward Jose-Cunilleras ◽  
Lawrence R. Dearth ◽  
Gloria S. Sivko ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscles ◽  
Glucose Transporter ◽  
Moderate Exercise ◽  
Glucose Transporter 4

scholarly journals Uncoupling protein-3 gene expression: reduced skeletal muscle mRNA in obese humans during pronounced weight loss

Diabetologia ◽  
1999 ◽  
Vol 42 (3) ◽  
pp. 302-309 ◽  
Author(s):  
H. Esterbauer ◽  
H. Oberkofler ◽  
G. Dallinger ◽  
D. Breban ◽  
E. Hell ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Weight Loss ◽  
Uncoupling Protein ◽  
Uncoupling Protein 3

scholarly journals Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region

2005 ◽  
Vol 386 (3) ◽  
pp. 505-513 ◽  
Author(s):  
Gemma SOLANES ◽  
Neus PEDRAZA ◽  
Verónica CALVO ◽  
Antonio VIDAL-PUIG ◽  
Bradford B. LOWELL ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Uncoupling Protein ◽  
Gene Promoter ◽  
Proximal Promoter ◽  
Ucp3 Gene ◽  
Uncoupling Protein 3

The transcription of the human UCP3 (uncoupling protein-3) gene in skeletal muscle is tightly regulated by metabolic signals related to fatty acid availability. However, changes in thyroid status also modulate UCP3 gene expression, albeit by unknown mechanisms. We created transgenic mice bearing the entire human UCP3 gene to investigate the effect of thyroid hormones on human UCP3 gene expression. Treatment of human UCP3 transgenic mice with thyroid hormones induced the expression of the human gene in skeletal muscle. In addition, transient transfection experiments demonstrate that thyroid hormones activate the transcription of the human UCP3 gene promoter when MyoD and the TR (thyroid hormone receptor) were co-transfected. The action of thyroid hormones on UCP3 gene transcription is mediated by the binding of the TR to a proximal region in the UCP3 gene promoter that contains a direct repeat structure. An intact DNA sequence of this site is required for thyroid hormone responsiveness and TR binding. Chromatin immunoprecipitation assays revealed that the TR binds this element in vivo. The murine Ucp3 gene promoter was also dependent on MyoD and responsive to thyroid hormone in transient transfection assays. However, it was much less sensitive to thyroid hormone than the human UCP3 promoter. In summary, UCP3 gene transcription is activated by thyroid hormone treatment in vivo, and this activation is mediated by a TRE (thyroid hormone response element) in the proximal promoter region. Such regulation suggests a link between UCP3 gene expression and the effects of thyroid hormone on mitochondrial function in skeletal muscle.

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