Usefulness and Limitations of a Serum Screening System to Predict the Risk of Gastric Cancer

BACKGROUND Gastroscopy is conducive to the early diagnosis of gastric cancer. It remains a key issue to screen premalignant patients who need gastroscopy in the clinic. Current screening strategies, including serum testing-based screening, are limited by high cost or invasive sampling, making them difficult to apply to large-scale natural populations. Therefore, a cost-effective and noninvasive auxiliary screening method that is suitable for large-scale application is urgently needed. OBJECTIVE The aim of this study was to construct a smartphone-based noninvasive auxiliary screening system suitable for screening patients with precancerous lesions of gastric cancer. Based on the auxiliary screening system, we expect to apply the concept of mobile health (mHealth) to establish a system to assist in screening natural populations at risk of gastric cancer and in need of gastroscopy. METHODS We developed the screening system by applying a naive Bayes classification algorithm based on collected questionnaires and gastritis medical records. We then established an affiliated app for application testing. The system was validated in three communities and we assessed the performance by comparison with other methods. RESULTS We constructed a “BIANQUE” screening system. First, we collected 841 questionnaires and 75,624 medical records. Second, we selected 9 risk factors in 20 factors. Third, we developed a screening system that achieved an AUC of 0.78 (95% CI [0.71,0.86]), comparable to blood testing-based screening methods (AUC=0.76). Fourth, we carried out a community validation. The odds ratio (OR) of different degrees of risk and gastric precancerous lesions was 2.85. CONCLUSIONS We have established an auxiliary screening system to help predict who needs gastroscopy. This system can achieve noninvasive and cost-effective testing with comparable performance to current invasive screening strategies. Thus, we speculate that this system could be easily applied on large-scale natural populations. CLINICALTRIAL Chinese clinical trial registry ChiCTR2100044006 http://www.chictr.org.cn/

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Gastric Cancer Screening System to Achieve Eradication of Gastric Cancer

Health Evaluation and Promotion ◽

10.7143/jhep.48.407 ◽

2021 ◽

Vol 48 (5) ◽

pp. 407-412

Author(s):

Takashi Ueda ◽

Hideki Mori ◽

Hidekazu Suzuki

Keyword(s):

Gastric Cancer ◽

Cancer Screening ◽

Screening System ◽

Gastric Cancer Screening

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Ultrastructural Cytochemical Study of Human Gastric Cancer: Observation of AKP ase,ACP ase,G6P ase,TPP ase and CO ase

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100158819 ◽

1990 ◽

Vol 48 (3) ◽

pp. 254-255

Author(s):

Dong Yuming ◽

Yang Guanglin ◽

Du Wei Dong ◽

Xu Ai Liam

Keyword(s):

Gastric Cancer ◽

Gastric Epithelium ◽

Human Gastric Cancer ◽

Electron Microscopic ◽

Cytochemical Study ◽

Electron Microscopic Cytochemistry ◽

Cytochemical Reaction ◽

Set Up ◽

Cancer Tissues ◽

Cytochemical Technique

The activities and distributions of AKPase ,ACPase,G6Pase,TPPase and COase in human normal gastric mucosa and gastric cancer tissues were studied histochemically at light microscopic level. These enzymes are the marker enzymes of cell membrane lysosome endoplasmic reticulum, Golgi apparatus and mitochondrion objectively. On the basis of the research we set up a special ultrastructural cytochemical technique and first researched into gastric cancer domesticly. Ultrastructural cytochemistry is also called electron microscopic cytochemistry. This new technique possesses both the sensitivity of cytochemical reaction andi the high resolution of electron microscope. It is characterized by direct observation,exact localization and the combination morphology with function.The distributions of AKPase,ACPase,G6Pase,TPPase and COase in 14 cases of gastric cancer and 1 case of gastric Denign lesion were studied ultrastructurally. The results showed: 1. normal gastric epithelium had no AKPase reaction. The reaction of ACPase,G6Pase,TPPase and Coase were found in the corresponding organella, which were consistent with their function.

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Ultrastructural Localization Study of Carcinoembryonic Antigen (CEA) in Gastric Cancer: Immunoelectron Microscopic Observation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100158807 ◽

1990 ◽

Vol 48 (3) ◽

pp. 252-253

Author(s):

Dong Yuming ◽

Yang Guanglin ◽

Wu Jifeng ◽

Chen Xiaolin

Keyword(s):

Gastric Cancer ◽

Intestinal Metaplasia ◽

Cancer Cells ◽

Microscopic Observation ◽

Biological Significance ◽

Ultrastructural Localization ◽

Mucinous Carcinoma ◽

Surface Glycoprotein ◽

Tubular Adenocarcinoma ◽

Pap Method

On the basis of light microscopic observation, the ultrastructural localization of CEA in gastric cancer was studied by immunoelectron microscopic technique. The distribution of CEA in gastric cancer and its biological significance and the mechanism of abnormal distribution of CEA were further discussed.Among 104 surgically resected specimens of gastric cancer with PAP method at light microscopic level, the incidence of CEA(+) was 85.58%. All of mucinous carcinoma exhibited CEA(+). In tubular adenocarcinoma the incidence of CEA(+) showed a tendency to rising with the increase of degree of differentiation. In normal epithelia and intestinal metaplasia CEA was faintly present and was found only in the luminal surface. The CEA staining patterns in cancer cells were of three types--- cytoplasmic, membranous and weak reactive type. The ultrastructural localization of CEA in 14 cases of gastric cancer was studied by immunoelectron microscopic technique.There was a little or no CEA in the microvilli of normal epithelia. In intestinal metaplasia CEA was found on the microvilli of absorptive cells and among the mucus particles of goblet cells. In gastric cancer CEA was also distributed on the lateral and basal surface or even over the entire surface of cancer cells and lost their polarity completely. Many studies had proved that the alterations in surface glycoprotein were characteristic changes of tumor cells. The antigenic determinant of CEA was glycoprotein, so the alterations of tumor-associated surface glycoprotein opened up a new way for the diagnosis of tumors.

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