scholarly journals PCR detection of retinoblastoma gene deletions in radiation-induced mouse lung adenocarcinomas

1994 ◽  
Author(s):  
M.E. Churchill ◽  
M.A. Gemmell ◽  
G.E. Woloschak
Keyword(s):  
Pcr Detection ◽  
Mouse Lung ◽  
Retinoblastoma Gene ◽  
Gene Deletions ◽  
Radiation Induced ◽  
Lung Adenocarcinomas

Detection of Retinoblastoma Gene Deletions in Spontaneous and Radiation-Induced Mouse Lung Adenocarcinomas by Polymerase Chain Reaction

1994 ◽  
Vol 137 (3) ◽  
pp. 310 ◽  
Author(s):  
Mark E. Churchill ◽  
M. Anne Gemmell ◽  
Gayle E. Woloschak
Keyword(s):  
Polymerase Chain Reaction ◽  
Mouse Lung ◽  
Retinoblastoma Gene ◽  
Chain Reaction ◽  
Gene Deletions ◽  
Radiation Induced ◽  
Polymerase Chain ◽  
Lung Adenocarcinomas

Comparative Proteomic Analysis of Radiation-Induced Changes in Mouse Lung: Fibrosis-Sensitive and -Resistant Strains

2008 ◽  
Vol 169 (4) ◽  
pp. 417-425 ◽  
Author(s):  
Xiaoping Ao ◽  
David M. Lubman ◽  
Mary A. Davis ◽  
Xianying Xing ◽  
Feng-Ming Kong ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Lung Fibrosis ◽  
Mouse Lung ◽  
Comparative Proteomic Analysis ◽  
Radiation Induced ◽  
Resistant Strains ◽  
Induced Changes

scholarly journals Depletion of Tumor-Associated Macrophages Slows the Growth of Chemically Induced Mouse Lung Adenocarcinomas

2014 ◽  
Vol 5 ◽  
Author(s):  
Jason M. Fritz ◽  
Meredith A. Tennis ◽  
David J. Orlicky ◽  
Hao Lin ◽  
Cynthia Ju ◽  
...  
Keyword(s):  
Mouse Lung ◽  
Tumor Associated Macrophages ◽  
Chemically Induced ◽  
Lung Adenocarcinomas

Radiation-induced strain differences in mouse alveolar inflammatory cell apoptosis

2005 ◽  
Vol 83 (1) ◽  
pp. 117-122 ◽  
Author(s):  
Thomas J O'Brien ◽  
Séverine Létuvé ◽  
Christina K Haston
Keyword(s):  
Cell Apoptosis ◽  
Caspase 3 ◽  
Inflammatory Cell ◽  
Strain Difference ◽  
Strain Differences ◽  
Inflammatory Cells ◽  
Mouse Lung ◽  
C3h Mice ◽  
Radiation Induced ◽  
Mouse Lungs

Whole-thorax irradiation results in the development of the diffuse inflammatory response alveolitis in C3H/HeJ (C3H) mice and a milder alveolitis with fibrosis in C57BL/6J (B6) mice. In this study, we investigate if this mouse strain difference in response to radiation is due to differences in lung inflammatory cell apoptosis. Mice of the C3H and B6 strains were given a radiation dose of 18 Gy to the thorax and the animals were sacrificed at 11 or 18 weeks following exposure or when they were moribund. Active caspase-3 staining was used to identify apoptotic cells in the alveolar space of histological lung sections from the mice. The apoptotic index of B6 mice was greater than that of C3H mice at 11 weeks postirradiation (17.8% of airspace cells vs. 7.8%, p = 0.028) and in mice sacrificed because of illness (27.3% vs. 14.4%, p = 0.036). No C3H mice survived to the later time point. The inflammatory cells undergoing apoptosis in the mouse lungs were morphologically consistent with alveolar macrophages. We conclude that a difference in inflammatory cell apoptosis may contribute to the disparate pulmonary radiation response of these mouse strains.Key words: mouse, lung, radiation, apoptosis, fibrosis, caspase-3.

scholarly journals Modeling progression in radiation-induced lung adenocarcinomas

2010 ◽  
Vol 49 (2) ◽  
pp. 169-176 ◽  
Author(s):  
Hatim Fakir ◽  
Werner Hofmann ◽  
Rainer K. Sachs
Keyword(s):  
Radiation Induced ◽  
Lung Adenocarcinomas

Loss of heterozygosity on chromosomes 1, 11, 12, and 14 in hybrid mouse lung adenocarcinomas

1996 ◽  
Vol 16 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Christopher R. Herzog ◽  
Bin Chen ◽  
Yian Wang ◽  
Herman A. J. Schut ◽  
Ming You
Keyword(s):  
Loss Of Heterozygosity ◽  
Mouse Lung ◽  
Hybrid Mouse ◽  
Lung Adenocarcinomas

Gene expression profile of PM014 of immortalized mouse lung epithelial cells in response to the effect of PM014 on radiation-induced fibrosis

2018 ◽  
Vol 19 (1) ◽  
pp. 107-114
Author(s):  
Dasom Shin ◽  
Kyung Goo Joo ◽  
Mi Jung Kang ◽  
Sehyun Pak ◽  
Youn-Sub Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Lung Epithelial Cells ◽  
Mouse Lung ◽  
Lung Epithelial ◽  
Radiation Induced

DETECTION OF DIFFERENTIALLY EXPRESSED GENES IN MOUSE LUNG ADENOCARCINOMAS

2001 ◽  
Vol 27 (3) ◽  
pp. 217-229 ◽  
Author(s):  
Lin Lin ◽  
Yian Wang ◽  
Gerald Bergman ◽  
Gary J. Kelloff ◽  
Ronald A. Lubet ◽  
...  
Keyword(s):  
Differentially Expressed Genes ◽  
Differentially Expressed ◽  
Mouse Lung ◽  
Lung Adenocarcinomas
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