scholarly journals Synthesis and Biological Activities of Natural Functionalized Polyamines: An Overview

2020 ◽  
Vol 27 ◽  
Author(s):  
Sophie Négrel ◽  
Jean Michel Brunel

: Recently, extensive researches have emphasized the fact that polyamines conjugates are becoming important in all the biological and medicinal fields. In this review we will focus our attention on natural polyamines and highlight recent progress in both fundamental mechanism studies and interest for the development and application for a therapeutic human use of polyamine derivatives.

ChemInform ◽  
2011 ◽  
Vol 42 (42) ◽  
pp. no-no
Author(s):  
Krystian Pluta ◽  
Beata Morak-Mlodawska ◽  
Malgorzata Jelen

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1888 ◽  
Author(s):  
Wenhua Chen ◽  
Huiying Tan ◽  
Qian Liu ◽  
Xiaohua Zheng ◽  
Hua Zhang ◽  
...  

Phellinus linteus is a popular medicinal mushroom that is widely used in China, Korea, Japan, and other Asian countries. P. linteus comprises various bioactive components, such as polysaccharides, triterpenoids, phenylpropanoids, and furans, and has proven to be an effective therapeutic agent in traditional Chinese medicine for the treatment and the prevention of various diseases. A number of studies have reported that P. linteus possesses many biological activities useful for pharmacological applications, including anticancer, anti-inflammatory, immunomodulatory, antioxidative, and antifungal activities, as well as antidiabetic, hepatoprotective, and neuroprotective effects. This review article briefly presents the recent progress made in understanding the bioactive components, biological activities, pharmacological applications, safety, and prospects of P. linteus, and provides helpful references and promising directions for further studies of P. linteus.


ChemInform ◽  
2014 ◽  
Vol 45 (39) ◽  
pp. no-no ◽  
Author(s):  
Kuo Xu ◽  
Fuhao Chu ◽  
Guoliang Li ◽  
Xin Xu ◽  
Penglong Wang ◽  
...  

2011 ◽  
Vol 46 (8) ◽  
pp. 3179-3189 ◽  
Author(s):  
Krystian Pluta ◽  
Beata Morak-Młodawska ◽  
Małgorzata Jeleń

Author(s):  
Wang Wang ◽  
Yueying Yang ◽  
Yang Liu ◽  
Dejuan Sun ◽  
Hua Li ◽  
...  

: Natural products have remarkable structural diversity and biological characteristics, providing researchers with more possibilities to develop novel drugs for disease therapeutics. Andrographolide, an ent-labdane diterpenoid from traditional Chinese medicines, Andrographis paniculata, exhibits a broad range of biological activities, which has been a hot area of research for several years. Up to now, lots of its derivatives with multiple bioactivities have been prepared through chemical modification. This review summarizes andrographolide derivatives prepared in the last ten years (2006-present), classifies them by different biological activities, and provides some discussion about the design of novel and potent derivatives.


2019 ◽  
Vol 27 (1) ◽  
pp. 407-421
Author(s):  
Ina Aneva ◽  
Peter Zhelev ◽  
Ekaterina Kozuharova ◽  
Kalina Danova ◽  
Seyed Fazel Nabavi ◽  
...  

2021 ◽  
Vol 8 (3) ◽  
pp. 031305
Author(s):  
Xue Jiang ◽  
Qinxi Liu ◽  
Jianpei Xing ◽  
Nanshu Liu ◽  
Yu Guo ◽  
...  

ARKIVOC ◽  
2013 ◽  
Vol 2014 (2) ◽  
pp. 233-293 ◽  
Author(s):  
Ruth Pérez-Fernández ◽  
Pilar Goya ◽  
José Elguero

Author(s):  
Wang Wang ◽  
Yutong Li ◽  
Yan Li ◽  
Dejuan Sun ◽  
Hua Li ◽  
...  

: Natural products have been proven as the main source of biologically active compounds, which are potentially useful for drug development. As one of the most studied pentacyclic triterpenes, oleanolic acid (OA) exhibits a broad range of biological activities and serves as a good scaffold for the development of novel derivatives that could be vital in drug discovery for various ailments. Up to now, many of its derivatives with multiple bioactivities have been prepared through chemical modification. This review summarizes the recent reports of OA derivatives (2016-present) and their biological effects and action mechanisms in vitro and in vivo models, and discusses the design of novel and potent derivatives.


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