In Search for Biomarkers in Obsessive-Compulsive Disorder: New Evidence on Saliva as a Practical Source of DNA to Assess Epigenetic Regulation

2021 ◽  
Vol 28 ◽  
Author(s):  
Claudio D'Addario ◽  
Monica Macellaro ◽  
Fabio Bellia ◽  
Beatrice Benatti ◽  
Eugenia Annunzi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Obsessive Compulsive Disorder ◽  
Epigenetic Regulation ◽  
Clinical Sample ◽  
Genomic Region ◽  
Bdnf Gene ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Epigenetic Biomarkers ◽  
Reliable Source

Background: Brain-Derived Neurotrophic Factor (BDNF) is a promising candidate biomarker in both the development and aetiology of different neuropsychiatric conditions, including obsessive-compulsive disorder (OCD). Most of the studies in the field have been carried out in blood cells, including peripheral blood mononucleated cells (PBMCs), although DNA of high quality can be easily isolated from saliva. Objective: The objective of this study was to evaluate the epigenetic regulation of the BDNF gene in the saliva of a clinical sample of OCD patients in order to assess this source as an alternative to blood. Methods: We first analyzed DNA methylation levels at BDNF in the saliva of subjects suffering from OCD (n= 50) and healthy controls (n=50). Then, we compared these data with the results previously obtained for the same genomic region in blood samples from the same patients and controls (CTRL). Results: Our preliminary data showed a significant reduction of 5mC levels at BDNF gene (OCD: 1.23 ± 0.45; CTRL: 1.85 ± 0.64; p < 0.0001) and a significant correlation between DNA methylation in PBMCs and saliva (Spearman r = 0.2788). Conclusion: We support the perspective that saliva could be a possible, reliable source, and a substitute for blood, in search of epigenetic biomarkers in OCD.

The role of DNA methylation of BDNF gene on clinical severity and cognitive performance in obsessive-compulsive disorder

2019 ◽  
Vol 29 ◽  
pp. S508-S509
Author(s):  
A. Ferrer Albertí ◽  
M. Barrachina ◽  
J. Labad ◽  
N. Salvat-Pujol ◽  
J. Ansede-Bermejo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cognitive Performance ◽  
Obsessive Compulsive Disorder ◽  
Clinical Severity ◽  
Bdnf Gene ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Symmetry Dimension in Obsessive–Compulsive Disorder: Prevalence, Severity and Clinical Correlates

2021 ◽  
Vol 10 (2) ◽  
pp. 274
Author(s):  
Aline P. Vellozo ◽  
Leonardo F. Fontenelle ◽  
Ricardo C. Torresan ◽  
Roseli G. Shavitt ◽  
Ygor A. Ferrão ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Obsessive Compulsive Disorder ◽  
Clinical Sample ◽  
Cross Sectional Study ◽  
Obsessive Compulsive ◽  
Chi Square ◽  
Cross Sectional ◽  
Compulsive Disorder ◽  
Clinical Correlates ◽  
Axis I

Background: Obsessive–compulsive disorder (OCD) is a very heterogeneous condition that frequently includes symptoms of the “symmetry dimension” (i.e., obsessions and/or compulsions of symmetry, ordering, repetition, and counting), along with aggressive, sexual/religious, contamination/cleaning, and hoarding dimensions. Methods: This cross-sectional study aimed to investigate the prevalence, severity, and demographic and clinical correlates of the symmetry dimension among 1001 outpatients from the Brazilian Research Consortium on Obsessive–Compulsive Spectrum Disorders. The main assessment instruments used were the Dimensional Yale–Brown Obsessive–Compulsive Scale, the Yale–Brown Obsessive–Compulsive Scale, the USP-Sensory Phenomena Scale, the Beck Depression and Anxiety Inventories, the Brown Assessment of Beliefs Scale, and the Structured Clinical Interview for DSM-IV Axis I Disorders. Chi-square tests, Fisher’s exact tests, Student’s t-tests, and Mann–Whitney tests were used in the bivariate analyses to compare patients with and without symptoms of the symmetry dimension. Odds ratios (ORs) with confidence intervals and Cohen’s D were also calculated as effect size measures. Finally, a logistic regression was performed to control for confounders. Results: The symmetry dimension was highly prevalent (86.8%) in this large clinical sample and, in the logistic regression, it remained associated with earlier onset of obsessive–compulsive symptoms, insidious onset of compulsions, more severe depressive symptoms, and presence of sensory phenomena. Conclusions: A deeper knowledge about specific OCD dimensions is essential for a better understanding and management of this complex and multifaceted disorder.

scholarly journals Directionality of change in obsessive compulsive disorder (OCD) and suicidal ideation over six years in a naturalistic clinical sample✰

2019 ◽  
Vol 245 ◽  
pp. 841-847 ◽  
Author(s):  
Lily A. Brown ◽  
Emily Wakschal ◽  
Stefanie Russman-Block ◽  
Christina L. Boisseau ◽  
Maria C. Mancebo ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Obsessive Compulsive Disorder ◽  
Clinical Sample ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Genetic Contribution of BDNF Gene in Obsessive Compulsive Disorder in Pakistani Punjabi Population

2017 ◽  
Vol 49 (4) ◽  
pp. 1523-1526
Author(s):  
Javeria Javeria ◽  
Masroor Ellahi Babar ◽  
Tanveer Hussain ◽  
Rashid Saif ◽  
Sadaf Rashid ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Genetic Contribution ◽  
Bdnf Gene ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Applying the Five-Factor Model of Personality to the Exploration of the Construct of Risk-Taking in Obsessive-Compulsive Disorder

2005 ◽  
Vol 34 (1) ◽  
pp. 31-42 ◽  
Author(s):  
Clare S. Rees ◽  
Rebecca A. Anderson ◽  
Sarah J. Egan
Keyword(s):  
Personality Traits ◽  
Obsessive Compulsive Disorder ◽  
Factor Model ◽  
Clinical Sample ◽  
Five Factor Model ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Neo Personality Inventory ◽  
Clinical Disorders ◽  
A Current

Although there has been a long interest in the personality traits associated with obsessive-compulsive disorder (OCD), few studies have examined differences on normal, dimensional personality traits for individuals with OCD compared with other clinical disorders. The purpose of this study was to replicate and extend upon the work of Rector et al. (2002) who found unique associations between OCD and trait domains and facets of the five-factor model of personality (FFM) when compared with a clinical sample of depressed individuals. The current study compared individuals with a current diagnosis of OCD (n=21) with individuals with a current diagnosis of anxiety or depression but no OCD symptoms (n=39) on the Revised NEO Personality Inventory (NEO PI-R Form S). Of particular interest was whether individuals with OCD would differ from other clinically anxious/depressed individuals on the actions facet of the FFM, as this facet is known to be related to harm and risk avoidance, and previous research suggests specific relationships between these forms of avoidance and OCD. Individuals with OCD were found to have lower scores on the actions, competence and self-discipline facets. These results add further support to previous research that suggests unique associations between trait domains and facets of the FFM and OCD.

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