A Computational Perspective on Drug Discovery and Signal Transduction Mechanism of Dopamine and Serotonin Receptors in the Treatment of Schizophrenia

2014 ◽  
Vol 15 (10) ◽  
pp. 916-926 ◽  
Author(s):  
Peng Lian ◽  
Lili Xu ◽  
Chuanrong Geng ◽  
Yuanyuan Qian ◽  
Wei Li ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Drug Discovery ◽  
Serotonin Receptors ◽  
Transduction Mechanism ◽  
Signal Transduction Mechanism ◽  
Computational Perspective ◽  
Dopamine And Serotonin Receptors

LEUKOTRIENE RECEPTORS AND SIGNAL TRANSDUCTION MECHANISM

1987 ◽  
pp. 81-139 ◽  
Author(s):  
Stanley T. Crooke ◽  
Seymour Mong ◽  
Mike CLark ◽  
G. Kurt Hogaboom ◽  
Monica Lewis ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Transduction Mechanism ◽  
Signal Transduction Mechanism ◽  
Leukotriene Receptors

scholarly journals Smoke-Isolated Karrikins Stimulated Tanshinones Biosynthesis in Salvia miltiorrhiza through Endogenous Nitric Oxide and Jasmonic Acid

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1229 ◽  
Author(s):  
Jie Zhou ◽  
Zi-xin Xu ◽  
Hui Sun ◽  
Lan-ping Guo
Keyword(s):  
Nitric Oxide ◽  
Signal Transduction ◽  
Jasmonic Acid ◽  
Hairy Root ◽  
Salvia Miltiorrhiza ◽  
Signal Molecules ◽  
Synthesis Inhibitor ◽  
Transduction Mechanism ◽  
Signal Transduction Mechanism ◽  
Nos Inhibitors

Although smoke-isolated karrikins (KAR1) could regulate secondary metabolism in medicinal plants, the signal transduction mechanism has not been reported. This study highlights the influence of KAR1 on tanshinone I (T-I) production in Salvia miltiorrhiza and the involved signal molecules. Results showed KAR1-induced generation of nitric oxide (NO), jasmonic acid (JA) and T-I in S. miltiorrhiza hairy root. KAR1-induced increase of T-I was suppressed by NO-specific scavenger (cPTIO) and NOS inhibitors (PBITU); JA synthesis inhibitor (SHAM) and JA synthesis inhibitor (PrGall), which indicated that NO and JA play essential roles in KAR1-induced T-I. NO inhibitors inhibited KAR1-induced generation of NO and JA, suggesting NO was located upstream of JA signal pathway. NO-induced T-I production was inhibited by SHAM and PrGall, implying JA participated in transmitting signal NO to T-I accumulation. In other words, NO mediated the KAR1-induced T-I production through a JA-dependent signaling pathway. The results helped us understand the signal transduction mechanism involved in KAR1-induced T-I production and provided helpful information for the production of S. miltiorrhiza hairy root.

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