A comprehensive review on microbubble concept, development and its application in therapeutics drug delivery and clinical management of disease

2020 ◽  
Vol 21 ◽  
Author(s):  
Sandeep Rathor ◽  
Sheikh Aamir ◽  
D.C. Bhatt ◽  
Krishan Kumar ◽  
Vikash Kumar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Clinical Management ◽  
Genetic Material ◽  
Specific Drug ◽  
Site Specific ◽  
Floating Drug Delivery ◽  
Biomedical Field ◽  
Gastro Retentive

Background:: The general purpose of this review was to briefly describe the gastro-retentive drug delivery system (GRDDS) and primary focuses on mechanisms of flotation for gastric retention. The principle mechanism of floating drug delivery systems (FDDS) is mainly based on hydro-dynamically controlled low-density system which gets swollen when come in contact with gastric environment and remain buoyant for extended period of time with improved bioavailability and therapeutic efficacy. The main perspective of this review was to focus on microbubble drug delivery due to its wide range of application. Microbubble is a new, economically viable and non-invasive technique which is alternative to conventional techniques. The size of microbubble ranges from 1-100 micrometers which contain oxygen or air and remain suspended for prolonged drug release. Due to its great potential microbubble is used in therapeutic delivery of drug molecule or genetic material at their specific targeted site in various diseases. The recent research also suggests that ultrasound mediated microbubble is more frequently used in biomedical field for imaging of site-specific molecule targeting for detection of disease and site-specific drug delivery. Conclusion:: Gastro-retentive floating drug delivery system was considered as most favorable approach for site-specific drug delivery. But nowadays, microbubble is gaining more popularity for its potential application in biomedical field. In recent years, there is much progress in microbubble for site specific delivery of drug or genetic material. Recent research also suggests that the ultrasound mediated microbubble have shown positive impact in the diagnosis and clinical management of various diseases such as Liver Cirrhosis, brain tumor, ocular and urinary tract infection.

scholarly journals A review on gastroretentive drug delivery system

2016 ◽  
Vol 4 (2) ◽  
pp. 01-10
Author(s):  
Shailaja Pant ◽  
Ashutosh Badola ◽  
Preeti Kothiyal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Specific Drug ◽  
Site Specific ◽  
Gastric Residence Time ◽  
Gastro Intestinal Tract ◽  
Novel Drug ◽  
Absorption Window ◽  
Gastro Retentive

Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Concept of novel drug delivery system arose to overcome certain aspect related to physicochemical properties of drug molecule and the related formulations. Gastro retentive drug delivery system is one of such novel approaches to prolong gastric residence time, thereby targeting site specific drug release in the stomach for local or systemic effects. This approach is useful particularly for the drugs which have narrow absorption window in the upper part of gastro intestinal tract. In this review we have been discussed various approaches of gastro retentive drug delivery system, such as floating and non-floating systems.

A Comprehensive Patent Review on β-cyclodextrin Cross-linked Nanosponges for Multiple Applications

2020 ◽  
Vol 14 (1) ◽  
pp. 75-89 ◽  
Author(s):  
Sandip Pawar ◽  
Pravin Shende
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Water Purification ◽  
Genetic Material ◽  
Aqueous Solubility ◽  
Solvent Evaporation ◽  
Specific Drug ◽  
Solvent Evaporation Method ◽  
Evaporation Method

Background: : Currently, the most important challenge in the development of therapeutics and actives is their poor aqueous solubility and bioavailability. Objective: : The low aqueous solubility, poor pharmacokinetic properties, and bioavailability associated with novel actives manifest in numerous challenges in the formulation of conventional dosage forms like tablets, capsules, suspensions, emulsions, etc. Nanosponges are a novel class of drug delivery system capable of encapsulating or entrapping both lipophilic and hydrophilic drugs. Target-specific drug delivery and controlled drug release are the advantages offered by nanosponges which make them a promising anti-tumor drug delivery system. Methods: Nanosponges are colloidal structures comprising solid nanoparticles with cavities and meshlike structures for encapsulation of wide varieties of substances like antineoplastic agents, proteins and peptides, volatile oils, genetic material, etc. The methods of preparation of β-cyclodextrin-based nanosponges include solvent evaporation method, emulsion solvent evaporation method, ultrasound-assisted synthesis, hyper cross-linked cyclodextrin and interfacial phenomenon method. A large variety of nanosponges- based formulations are available in the market and some formulations of prostavastin, brexin, glymesason, mena-gargle, etc. are under clinical trials. Results: : Nanosponges possess potential applications in target site-specific drug delivery to liver, spleen, and lungs. Due to the surface functionalization, nanosponges show broad applications in water purification, protein delivery, chemical sensors, detection of explosives, agriculture, etc. In the near future, nanosponges-based products will capture a huge market for commercialization due to their improved properties and advantages. Conclusion: : This review provides an account of the patents related to nanosponges (2006-2018) and covers the broad applications of β-cyclodextrin-based nanosponges, their roles in vaccine delivery, cancer therapy, fire engineering, water purification, etc.

scholarly journals Microballoons: A Gastro Retentive Drug Delivery System

2019 ◽  
Vol 9 (4-s) ◽  
pp. 625-630
Author(s):  
Ankita Srivastava ◽  
Ruchi Shukla ◽  
Kusum Sharma ◽  
Hitesh Jain ◽  
D. B. Meshram
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gastric Fluid ◽  
Oral Route ◽  
Gastric Retention ◽  
Preparation Temperature ◽  
Novel Technology ◽  
Floating Drug Delivery ◽  
Gastro Retentive

Oral route is most preferable and widely used route for the administration of drug. Microballoons becomes novel technology in pharmaceutical field in the floating drug delivery for achieving the gastric retention. Microballoons are also called as hollowspheres which are porous smooth in nature and thus show good floating properties in gastric fluid. Microballoons release the drug in controlled manner at the targeted site. Microballoons are spherical empty vesicles without core and that can remain buoyant in gastric region for prolong period of time without irritation in gastrointestinal tract. Multiparticulate particles having a low density system that can efficiently prolong the gastric retention time of the drugs, thus enhanced bioavailability and thus improve the dosing frequency. These are less soluble at higher pH environment. As microballoons delivery systems provide longer retention in gastric pH and enhance the solubility of drugs that are less soluble in high pH environment. The formation of cavity inside the microballoons depend on the preparation, temperature and the surface smoothness determine the floatability and the release rate of microballoons. Keywords: Microballoons, Gastro retentive drug delivery system, Hollowspheres, Controlled release

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