The Molecular Recognition Paradigm of Environmental Chemicals with Biomacromolecules

SummaryAim: Multiple chemical sensitivity (MCS) is a controversially discussed symptom complex. Patients afflicted by MCS react to very low and generally nontoxic concentrations of environmental chemicals. It has been suggested that MCS leads to neurotoxic damage or neuroimmunological alteration in the brain detectable by positron emission tomography (PET) and single photon emission computer tomography (SPECT). These methods are often applied to MCS patients for diagnosis, although they never proved appropriate. Method: We scanned 12 MCS patients with PET, hypothesizing that it would reveal abnormal findings. Results: Mild glucose hypometabolism was present in one patient. In comparison with normal controls, the patient group showed no significant functional brain changes. Conclusion: This first systematic PET study in MCS patients revealed no hint of neurotoxic or neuroimmuno-logical brain changes of functional significance.

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HAZARD: An Expert System for Risk Assessment of Environmental Chemicals

Methods of Information in Medicine ◽

10.1055/s-0038-1635482 ◽

1987 ◽

Vol 26 (01) ◽

pp. 13-23 ◽

Cited By ~ 2

Author(s):

H. W. Gottinger

Keyword(s):

Expert System ◽

Structural Information ◽

Chemical Carcinogenesis ◽

Structural Features ◽

Environmental Chemicals ◽

Chemical Carcinogens ◽

Carcinogenic Activity ◽

Current State ◽

Structure Activity ◽

Carcinogenic Potential

AbstractThe purpose of this paper is to report on an expert system in design that screens for potential hazards from environmental chemicals on the basis of structure-activity relationships in the study of chemical carcinogenesis, particularly with respect to analyzing the current state of known structural information about chemical carcinogens and predicting the possible carcinogenicity of untested chemicals. The structure-activity tree serves as an index of known chemical structure features associated with carcinogenic activity. The basic units of the tree are the principal recognized classes of chemical carcinogens that are subdivided into subclasses known as nodes according to specific structural features that may reflect differences in carcinogenic potential among chemicals in the class. An analysis of a computerized data base of known carcinogens (knowledge base) is proposed using the structure-activity tree in order to test the validity of the tree as a classification scheme (inference engine).

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Recent Trends in Molecular Recognition

10.1007/978-3-662-03574-0 ◽

1998 ◽

Cited By ~ 1

Keyword(s):

Molecular Recognition ◽

Recent Trends

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A Three-Dimensional Tetraphenylethylene-Based Fluorescence Covalent Organic Framework for Molecular Recognition

10.26434/chemrxiv.12982019 ◽

2020 ◽

Author(s):

Junxia Ren ◽

Yaozu Liu ◽

Xin Zhu ◽

Yangyang Pan ◽

Yujie Wang ◽

...

Keyword(s):

Molecular Recognition ◽

Fluorescence Probe ◽

Three Dimensional ◽

Hazardous Substances ◽

Covalent Organic Framework ◽

Highly Sensitive ◽

Volatile Organic ◽

Polycyclic Aromatic ◽

Better Than ◽

Organic Framework

<a></a><a></a><a></a><a></a><a></a><a></a><a></a><a>The development of highly-sensitive recognition of </a><a></a><a></a><a></a><a></a><a>hazardous </a>chemicals, such as volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs), is of significant importance because of their widespread social concerns related to environment and human health. Here, we report a three-dimensional (3D) covalent organic framework (COF, termed JUC-555) bearing tetraphenylethylene (TPE) side chains as an aggregation-induced emission (AIE) fluorescence probe for sensitive molecular recognition.<a></a><a> </a>Due to the rotational restriction of TPE rotors in highly interpenetrated framework after inclusion of dimethylformamide (DMF), JUC-555 shows impressive AIE-based strong fluorescence. Meanwhile, owing to the large pore size (11.4 Å) and suitable intermolecular distance of aligned TPE (7.2 Å) in JUC-555, the obtained material demonstrates an excellent performance in the molecular recognition of hazardous chemicals, e.g., nitroaromatic explosives, PAHs, and even thiophene compounds, via a fluorescent quenching mechanism. The quenching constant (KSV) is two orders of magnitude better than those of other fluorescence-based porous materials reported to date. This research thus opens 3D functionalized COFs as a promising identification tool for environmentally hazardous substances.

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Biomimetic Extracellular Vesicles Embedded with Black Phosphorus for Molecular Recognition-Guided Biomineralization

10.26434/chemrxiv.6721553.v1 ◽

2018 ◽

Author(s):

Yingqian Wang ◽

Xiaoxia Hu ◽

Lingling Zhang ◽

Chunli Zhu ◽

Jie Wang ◽

...

Keyword(s):

Molecular Recognition ◽

Extracellular Vesicles ◽

Inorganic Phosphate ◽

Physiological Activity ◽

Medical Engineering ◽

Matrix Vesicles ◽

Black Phosphorus ◽

Photothermal Effect ◽

Biological Processes ◽

Extracellular Environment

Extracellular vesicles (EVs) are involved in the regulation of cell physiological activity and the reconstruction of extracellular environment. Matrix vesicles (MVs) are a type of EVs, and they participate in the regulation of cell mineralization. Herein, bioinspired MVs embedded with black phosphorus are functionalized with cell-specific aptamer (denoted as Apt-bioinspired MVs) for stimulating biomineralization. The aptamer can direct bioinspired MVs to targeted cells, and the increasing concentration of inorganic phosphate originated from the black phosphorus can facilitate cell biomineralization. The photothermal effect of the Apt-bioinspired MVs also positively affects mineralization. In addition, the Apt-bioinspired MVs display outstanding bone regeneration performance. Considering the excellent behavior of the Apt-bioinspired MVs for promoting biomineralization, our strategy provides a way of designing bionic tools for studying the mechanisms of biological processes and advancing the development of medical engineering.

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Arylboronic Acids in Self-condensation of Glucosamines Forming Deoxyfructosazine, Catalysts or Reagents?

10.26434/chemrxiv.7528376 ◽

2019 ◽

Author(s):

Meifeng Wang ◽

Gan Zhu ◽

Yiqun Li ◽

Liuqun Gu

Keyword(s):

Molecular Recognition ◽

Boric Acid ◽

Boronic Acid ◽

Catalytic Mechanism ◽

Organic Transformations ◽

Food Industries ◽

Arylboronic Acids ◽

Excess Amount ◽

Phenyl Boronic Acid ◽

Boron Acid

Arylboronic acids were widely used as efficient catalysts in direct amide formation and other organic transformations. Surprisingly, reports on their use as catalysts in carbohydrates synthesis are very rare even though boron acid-diol complexation was extensively investigated in molecular recognition for saccharides and so on. Here we developed an efficient arylboronic acids catalyzed dimerization of glucosamines forming deoxyfructosazine which is important compound in pharmaceutical and food industries, against a commonly held belief that excess amount of phenyl boronic acid (or boric acid) is a must. A catalytic mechanism was also proposed and arylboronic acids instead of their boronates was identified as catalysts.

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