Recent Advances in the Discovery of Metallo-β--Lactamase Inhibitors for β-lactam Antibiotic-Resistant Reversing Agents

2014 ◽  
Vol 15 (7) ◽  
pp. 689-702 ◽  
Author(s):  
Zhenzhen Guo ◽  
Shutao Ma
Keyword(s):  
Antibiotic Resistant ◽  
Recent Advances ◽  
Lactam Antibiotic ◽  
Reversing Agents

Molecular Characterization of β-lactam Antibiotic Resistant Pseudomonas aeruginosa Isolated from Egyptian Food

2017 ◽  
Vol 13 (3) ◽  
pp. 313-322
Author(s):  
Shehab E. Talat ◽  
Mahmoud Abd El-Mongy ◽  
Mona I. Mabrouk ◽  
A.B. Abeer Mohammed ◽  
Hanafy A. Hamza
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Molecular Characterization ◽  
Antibiotic Resistant ◽  
Lactam Antibiotic

scholarly journals A bacteriocin-based antimicrobial formulation to effectively disrupt the cell viability of methicillin-resistant Staphylococcus aureus (MRSA) biofilms

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Christian Kranjec ◽  
Kirill V. Ovchinnikov ◽  
Torstein Grønseth ◽  
Kumar Ebineshan ◽  
Aparna Srikantam ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cell Viability ◽  
Cell Damage ◽  
Penicillin G ◽  
Antibiotic Resistant ◽  
Methicillin Resistant ◽  
Lactam Antibiotic ◽  
Mrsa Strains ◽  
Therapeutic Tools

AbstractAntibiotic-resistant and biofilm-associated infections brought about by methicillin-resistant Staphylococcus aureus (MRSA) strains is a pressing issue both inside as well as outside nosocomial environments worldwide. Here, we show that a combination of two bacteriocins with distinct structural and functional characteristics, garvicin KS, and micrococcin P1, showed a synergetic antibacterial activity against biofilms produced in vitro by S. aureus, including several MRSA strains. In addition, this bacteriocin-based antimicrobial combination showed the ability to restore the sensitivity of the highly resilient MRSA strain ATCC 33591 to the β-lactam antibiotic penicillin G. By using a combination of bacterial cell metabolic assays, confocal and scanning electron microscopy, we show that the combination between garvicin KS, micrococcin P1, and penicillin G potently inhibit cell viability within S. aureus biofilms by causing severe cell damage. Together these data indicate that bacteriocins can be valuable therapeutic tools in the fight against biofilm-associated MRSA infections.

scholarly journals Effects of reducing beta-lactam antibiotic pressure on intestinal colonization of antibiotic-resistant gram-negative bacteria

2009 ◽  
Vol 36 (3) ◽  
pp. 512-519 ◽  
Author(s):  
Saskia Nijssen ◽  
Ad Fluit ◽  
David van de Vijver ◽  
Janetta Top ◽  
Rob Willems ◽  
...  
Keyword(s):  
Gram Negative Bacteria ◽  
Intestinal Colonization ◽  
Beta Lactam ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Beta Lactam Antibiotic ◽  
Lactam Antibiotic

Recent Advances in Peptide Nucleic Acids as Antibacterial Agents

2020 ◽  
Vol 27 ◽  
Author(s):  
Wei Chen ◽  
Bo Dong ◽  
Wenen Liu ◽  
Zhengchun Liu
Keyword(s):  
Messenger Rna ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Resistant Bacteria ◽  
Attractive Alternative ◽  
Dependent Manner ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Recent Advances ◽  
Hybrid Complex

: The emergence of antibiotic-resistant bacteria and the slow progress in searching for new antimicrobial agents make it hard to treat bacterial infections and cause problems for the healthcare system worldwide, including high costs, prolonged hospitalizations, and increased mortality. Therefore, the discovery of effective antibacterial agents is of great importance. One attractive alternative is antisense peptide nucleic acid (PNA), which inhibits or eliminates gene expression by binding to the complementary messenger RNA (mRNA) sequence of essential genes or the accessible and functionally important regions of the ribosomal RNA (rRNA). Following 30 years of development, PNAs have played an extremely important role in the treatment of Gram-positive, Gram-negative, and acidfast bacteria due to their desirable stability of hybrid complex with target RNA, the strong affinity for target mRNA/rRNA, and the stability against nucleases. PNA-based antisense antibiotics can strongly inhibit the growth of pathogenic and antibiotic-resistant bacteria in a sequence-specific and dose-dependent manner at micromolar concentrations. However, several fundamental challenges, such as intracellular delivery, solubility, physiological stability, and clearance, still need to be addressed before PNAs become broadly applicable in clinical settings. In this review, we summarize the recent advances in PNAs as antibacterial agents and the challenges that need to be overcome in the future.

scholarly journals Is household antibiotic use a risk factor for antibiotic-resistant pneumococcal infection?

2002 ◽  
Vol 129 (3) ◽  
pp. 499-505 ◽  
Author(s):  
T. S. KWAN-GETT ◽  
R. L. DAVIS ◽  
D. K. SHAY ◽  
S. BLACK ◽  
H. SHINEFIELD ◽  
...  
Keyword(s):  
Pneumococcal Disease ◽  
Pneumococcal Infection ◽  
Antibiotic Use ◽  
Health Maintenance Organizations ◽  
Antibiotic Resistant ◽  
Health Maintenance ◽  
Group Data ◽  
Increased Risk ◽  
Resistant Infection ◽  
Lactam Antibiotic

We used microbiology and pharmacy data from health-maintenance organizations to determine whether antibiotic use by a household member increases the risk of penicillin-non-susceptible pneumococcal disease. Though it has been well established that an individual's antibiotic use increases one's risk of antibiotic-resistant infection, it is unclear whether the risk is increased if a member of one's household is exposed to antibiotics. We therefore conducted a case-control study of patients enrolled in health maintenance organizations in Western Washington and Northern California. Cases were defined as individuals with penicillin-non-susceptible pneumococcal infection; controls were individuals with penicillin-susceptible pneumococcal infection. Socioeconomic variables were obtained by linking addresses with 1997 census block group data. One-hundred and thirty-four cases were compared with 798 controls. Individual antibiotic use prior to diagnosis increased the odds of penicillin non-susceptibility, with the strongest effect seen for β-lactam use within 2 months (OR 1·8, 95% CI 1·2, 2·8). When household antibiotic use by persons other than the patient were considered, at 4 months prior to diagnosis there was a trend towards an association between penicillin non-susceptibility and β-lactam antibiotic use, and a possible association in a small subgroup of patients with eye and ear isolates. However, no significant overall pattern of association was seen. We conclude that though antibiotic use of any kind within 2 months prior to diagnosis is associated with an increased risk of penicillin-non-susceptible pneumococcal disease, there is no significant overall pattern of association between household antibiotic use and penicillin-non-susceptible pneumococcal infection.

Quantitative Removal of β-Lactam Antibiotic Activity by Hydroxyl Radical Reaction in Water: How Much Oxidation is Enough?

2013 ◽  
Vol 16 (1) ◽  
Author(s):  
Stephen P. Mezyk ◽  
Shauna C. Otto
Keyword(s):  
Radical Reaction ◽  
Antibiotic Activity ◽  
Aquatic Environments ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
Reduction Processes ◽  
Lactam Antibiotic ◽  
Additional Water ◽  
Water Treatments ◽  
Reaction In Water

AbstractThe β-lactam antibiotics are some of the most persistent anthropogenic pharmaceutical contaminants, and consequently are currently being detected in many aquatic environments. The presence of any level of antibiotics in water may contribute to the emergence of antibiotic-resistant bacterial strains, and therefore the active removal of these pharmaceuticals by additional water treatments such as advanced oxidation and reduction processes may be required. In this study, we report on our efficiency measurements for the hydroxylradical- based degradation of three β-lactam antibiotics obtained using steady-state

Sign in / Sign up

Export Citation Format

Share Document