When Neighbors Talk: Colon Cancer Cell Invasion and Tumor Microenvironment Myofibroblasts

2017 ◽  
Vol 18 (8) ◽  
pp. 964-982 ◽  
Author(s):  
Jolien Bridelance ◽  
Zuzanna Drebert ◽  
Olivier De Wever ◽  
Marc Bracke ◽  
Ilse M. Beck
Keyword(s):  
Colon Cancer ◽  
Tumor Microenvironment ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Colon Cancer Cell ◽  
Cancer Cell Invasion

M2-like macrophages induce colon cancer cell invasion via matrix metalloproteinases

2017 ◽  
Vol 232 (12) ◽  
pp. 3468-3480 ◽  
Author(s):  
Katyayni Vinnakota ◽  
Yuan Zhang ◽  
Benson Chellakkan Selvanesan ◽  
Geriolda Topi ◽  
Tavga Salim ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Matrix Metalloproteinases ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Colon Cancer Cell ◽  
Cancer Cell Invasion

scholarly journals GATA6 Promotes Colon Cancer Cell Invasion by Regulating Urokinase Plasminogen Activator Gene Expression

Neoplasia ◽  
2010 ◽  
Vol 12 (11) ◽  
pp. 856-IN1 ◽  
Author(s):  
Narasimhaswamy S Belaguli ◽  
Muhammad Aftab ◽  
Mohammed Rigi ◽  
Mao Zhang ◽  
Daniel Albo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Plasminogen Activator ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Urokinase Plasminogen Activator ◽  
Colon Cancer Cell ◽  
Cancer Cell Invasion

scholarly journals Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF–κB, uPA activator and MMP9

2016 ◽  
Vol 12 (5) ◽  
pp. 4139-4146 ◽  
Author(s):  
Weihua Tong ◽  
Quan Wang ◽  
Donghui Sun ◽  
Jian Suo
Keyword(s):  
Colon Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Colon Cancer Cell ◽  
Cancer Cell Invasion

scholarly journals Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Qi-Hong Jiang ◽  
Ai-Xiang Wang ◽  
Yan Chen
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Colon Cancer Cell ◽  
Erk Pathway ◽  
Colon Cancer Cells ◽  
Cancer Cell Invasion ◽  
Invasion And Migration ◽  
And Migration

As a member of the ezrin-radixin-moesin (ERM) family, radixin is overexpressed in many tumor tissues. However, little is known about its role in the progression of colon cancer. So we here aimed to determine the function of radixin in colon cancer cell invasion. Interestingly, we found that the expression of radixin was significantly elevated in colon cancer cells. Knockdown of radixin suppressed the invasion and migration of colon cancer cells. Further, knockdown of radixin inhibited the activation of Rac1 and ERK1/2, and decreased the expression and secretion of MMP-7. In addition, Rac1-ERK signaling pathway was required for the radixin-promoted invasion and MMP-7 production. Together, our findings suggest that radixin enhances the invasion and migration of colon cancer cells. Activation of Rac1-ERK pathway and consequent upregulation of MMP-7 production may contribute to the function of radixin in the regulation of colon cancer cell invasion. Thus, radixin may act as a novel target for the diagnosis and treatment of colon cancer.

Sign in / Sign up

Export Citation Format

Share Document