The Research Progress of DPP-4 Inhibitors

2020 ◽  
Vol 20 (17) ◽  
pp. 1709-1718
Author(s):  
Zhi-Gang Sun ◽  
Zhi-Na Li ◽  
Hai-Liang Zhu
Keyword(s):  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Research Progress ◽  
Dipeptidyl Peptidase 4 ◽  
Type 2 Dm ◽  
Reduce Blood Glucose ◽  
Sugar Levels ◽  
Diabetes Patients

Diabetes mellitus (DM) is a metabolic disease, and diabetes patients have long-term higher blood sugar levels than standard. Most people with diabetes have complications that greatly affect their standard of living. Patients with type 2 DM occupy the vast majority of all diabetes patients. Glucagonlike peptide-1 (GLP-1) secreted by intestinal enteroendocrine L-cells is a small molecule polypeptide, which is glucose concentration-dependent and can effectively reduce blood glucose concentration. Dipeptidyl peptidase-4 (DPP-4) is an important target for the treatment of type 2 DM because it can degrade GLP-1. DPP-4 inhibitors can enhance the blood glucose lowering effect of GLP-1 by inhibiting DPP-4. This article summarizes the development of DPP-4 inhibitors from 2015 to 2019, and can provide helpful information for the discovery of novel DPP-4 inhibitors in the future.

scholarly journals The Research of Improved Grey GM (1, 1) Model to Predict the Postprandial Glucose in Type 2 Diabetes

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Yannian Wang ◽  
Fenfen Wei ◽  
Changqing Sun ◽  
Quanzhong Li
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Prediction Model ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Original Data ◽  
Postprandial Glucose ◽  
Postprandial Blood Glucose ◽  
Glucose Prediction

Diabetes may result in some complications and increase the risk of many serious health problems. The purpose of clinical treatment is to carefully manage the blood glucose concentration. If the blood glucose concentration is predicted, treatments can be taken in advance to reduce the harm to patients. For this purpose, an improved grey GM (1, 1) model is applied to predict blood glucose with a small amount of data, and especially in terms of improved smoothness it can get higher prediction accuracy. The original data of blood glucose of type 2 diabetes is acquired by CGMS. Then the prediction model is established. Finally, 50 cases of blood glucose from the Henan Province People’s Hospital are predicted in 5, 10, 15, 20, 25, and 30 minutes, respectively, in advance to verify the prediction model. The prediction result of blood glucose is evaluated by the EGA, MSE, and MAE. Particularly, the prediction results of postprandial blood glucose are presented and analyzed. The result shows that the improved grey GM (1, 1) model has excellent performance in postprandial blood glucose prediction.

The effect of premixed insulin to blood glucose concentration in patients with type 2 diabetes mellitus

2020 ◽  
Vol 30 (6) ◽  
Author(s):  
Arina D. Puspitasari ◽  
Hayu Kusuma ◽  
Dinda M.N. Ratri ◽  
Cahyo Wibisono ◽  
Budi Suprapti
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Postprandial Blood Glucose ◽  
Premixed Insulin ◽  
Acting Insulin ◽  
Blood Glucose Concentrations

AbstractBackgroundOne of the therapies used to treat type 2 diabetes mellitus (T2DM) disease is combination insulin which consists of rapid-acting insulin and intermediate-acting insulin (premixed). This study aimed to examine the profile of premixed insulin related to blood glucose concentration and to identify the drug interactions due to the combination of premixed insulin with other drugs taken by T2DM patients.MethodsThis study was a prospective observational study with cross-sectional data that were analyzed descriptively. The respondents invited were T2DM patients with or without complication or comorbid disease who received premixed insulin with or without a combination of oral antidiabetic therapy in the Outpatient Unit of Universitas Airlangga Hospital, Surabaya. The research instruments used are data sheet, patient medical record, and fasting and postprandial blood glucose concentration.ResultsA total of 118 patients received premixed insulin therapy, but only 80 patients were included in the inclusion criteria. Based on types of insulin, the combination of 30% aspart and 70% protamine aspart was used by 91.25% T2DM patients, and a combination of 25% insulin lispro and 75% protamine lispro was used by 8.75% T2DM patients. There were 30.3% of patients who could achieve the target of 80–130 mg/dL in fasting blood glucose concentrations, and 35.1% of patients achieved the target of ≤180 mg/dL in postprandial blood glucose concentration. Drug interactions may occur in patients who use premixed insulin with glimepiride, lisinopril, fenofibrate, candesartan, irbesartan, and gemfibrozil.ConclusionsIn this study, premixed insulin have not reached the target of fasting and postprandial blood glucose concentrations in most patients.

scholarly journals Carbohydrate utilization in the pre-ruminant calf

1969 ◽  
Vol 23 (2) ◽  
pp. 333-341 ◽  
Author(s):  
R. C. Siddons ◽  
R. H. Smith ◽  
M. J. Henschel ◽  
W. B. Hill ◽  
J. W. G. Porter
Keyword(s):  
Blood Glucose ◽  
Linear Relationship ◽  
Blood Sugar ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Reducing Sugar ◽  
Carbohydrate Utilization ◽  
Proximal Duodenum ◽  
Preferential Uptake ◽  
Sugar Levels

1. Changes in blood sugar levels after giving carbohydrates have been used to assess carbohydrate utilization in pre-ruminant calves aged between 10 and 50 days.2. Glucose, galactose and lactose were readily utilized by all calves; the utilization of glucose and galactose increased with age, whereas that of lactose remained constant.3. Maltose and fructose utilization was low in young calves and increased slightly with age.4. Sucrose and starch were not utilized.5. Studies with three older pre-ruminant calves (aged 53, 88 and 106 days) in which the carbohydrates were infused into the proximal duodenum showed that glucose, galactose, lactose and xylose all caused marked increases in the level of blood reducing sugar, whereas fructose and sucrose caused no increase, and maltose was intermediate. Xylose and galactose caused very little change in the blood glucose concentration.6. It appeared that preferential uptake occurred of glucose from a glucose-galactose mixture.7. A non-linear relationship was found between the concentration of glucose or galactose infused and the increase in the level of blood reducing sugar.

Effect of basal insulin dosage on blood glucose concentration in ambulatory surgery patients with type 2 diabetes

2017 ◽  
Vol 36 ◽  
pp. 184-188 ◽  
Author(s):  
Linda J. Demma ◽  
Karen T. Carlson ◽  
Elizabeth W. Duggan ◽  
John Gordon Morrow ◽  
Guillermo Umpierrez
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Basal Insulin ◽  
Ambulatory Surgery ◽  
Blood Glucose Concentration ◽  
Insulin Dosage

scholarly journals Efektivitas Penggunaan Oral Antidiabetes Kombinasi Glimepiride Dengan Pioglitazone Pada Pasien Dibetes Mellitus Tipe 2

2020 ◽  
Vol 5 (1) ◽  
pp. 1-6
Author(s):  
Ninik Mas Ulfa ◽  
Nabila Arfiana
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Blood Glucose Control ◽  
Pharmacological Therapy ◽  
The Body ◽  
Type 2 Dm ◽  
Oral Antidiabetic ◽  
Retrospective Data Collection ◽  
Sugar Levels

Diabetes mellitus is a disorder of chronic metabolic syndrome from carbohydrates, lipids and fats resulting from the deficiency of insulin in the body so that it can cause hyperglycemia. Oral Antidiabetic and Insulin is pharmacological therapy that can control blood sugar levels. This study aims to observe the effectiveness of Glimepiride combination therapy with Pioglitazone in type 2 DM patients with fasting blood Glucose and blood Glucose 2 hour post prandial parameters compared to pre and post values. This research method is observational with retrospective data collection and data analyzed descriptively. The sample size was 30 type 2 DM patients who received therapy after 6 months. The results showed that there were significant differences between the value of  fasting blood Glucose pre and fasting blood Glucose post and blood Glucose 2 hour post prandial pre and blood Glucose 2 hour post from statistical analysis using paired t-test, with a value of α = 0.00 smaller than α = 0.05. This shows that the combination of Glimepiride with Pioglitazone is effective in blood glucose control in type 2 DM patients. Keywords: Dibetes Mellitus, Oral Antidiabetic, Glimepiride, Piogliatzone

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