Recent Progress in Anticonvulsant Drug Research: Strategies for Anticonvulsant Drug Development and Applications of Antiepileptic Drugs for Non-Epileptic Central Nervous System Disorders

2012 ◽  
Vol 12 (9) ◽  
pp. 1033-1071 ◽  
Author(s):  
Sevim Dalkara ◽  
Arzu Karakurt
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Development ◽  
Antiepileptic Drugs ◽  
Recent Progress ◽  
Drug Research ◽  
Anticonvulsant Drug ◽  
Research Strategies ◽  
Central Nervous System Disorders

scholarly journals Takotsubo Cardiomyopathy as a Complication/ Sequelae of Prolonged Refractory Seizure: A Case Report from Nepal

2021 ◽  
Author(s):  
Bikash Khadka ◽  
Kishor Khanal
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Intensive Care ◽  
Case Report ◽  
Antiepileptic Drugs ◽  
Takotsubo Cardiomyopathy ◽  
Cardiac Enzymes ◽  
Recurrent Seizure ◽  
Mortality And Morbidity ◽  
Central Nervous System Disorders

Takotsubo cardiomyopathy(TC) is a reversible, yet underdiagnosed cause of mortality and morbidity in the intensive care units. It occurs secondary to sudden catecholamine surge precipitated by any form of emotional or pathological stress. Association between central nervous system disorders and Takotsubo cardiomyopathy is being increasingly reported. Epilepsy is the second most common CNS disorder to trigger TC, SAH being the first. We report a case of TC in an elderly man with prolonged, recurrent seizure episodes refractory to the commonly used antiepileptic drugs (AEDs), who developed unexplained tachycardia, hypotension and elevated cardiac enzymes.

Challenges in drug development for central nervous system disorders: a European Medicines Agency perspective

2016 ◽  
Vol 15 (12) ◽  
pp. 813-814 ◽  
Author(s):  
Florence Butlen-Ducuing ◽  
Frank Pétavy ◽  
Lorenzo Guizzaro ◽  
Malgorzata Zienowicz ◽  
Tomas Salmonson ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Development ◽  
European Medicines Agency ◽  
Central Nervous System Disorders

scholarly journals Inflammasome-Mediated Inflammation in Neurodegenerative Diseases

2019 ◽  
Vol 13 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Jun Young Park ◽  
Yeo Wool Kang ◽  
Won Gil Cho
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Inflammatory Cytokines ◽  
Neurodegenerative Disorders ◽  
Protein Complex ◽  
Recent Progress ◽  
Biological Function ◽  
Central Nervous System Disorders ◽  
Inflammatory Processes ◽  
Pro Inflammatory Cytokines

Inflammasomes are protein platforms consisting of multiple proteins. The biological function includes the activation of caspase-1, leading to the maturation of IL-1β and IL-18. These pro-inflammatory cytokines promote fundamental inflammatory processes in numerous infectious diseases. The inflammasome-mediated inflammation has become increasingly important in central nervous system disorders. In neurodegenerative disorders, significant contributors to disease progression include neuroinflammation and inflammatory cascades initiated by the inflammasome protein complex. This review discusses the recent progress of research on inflammasome associated with neurodegenerative disorders.

Implications of sex-related differences in central nervous system disorders for drug research and development

2021 ◽  
Author(s):  
Florence Butlen-Ducuing ◽  
Ewa Balkowiec-Iskra ◽  
Christina Dalla ◽  
David A. Slattery ◽  
Maria Teresa Ferretti ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Research And Development ◽  
Drug Research ◽  
Central Nervous System Disorders

Two decades of new drug development for central nervous system disorders

2015 ◽  
Vol 14 (12) ◽  
pp. 815-816 ◽  
Author(s):  
Aaron S. Kesselheim ◽  
Thomas J. Hwang ◽  
Jessica M. Franklin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Development ◽  
New Drug ◽  
Central Nervous System Disorders ◽  
New Drug Development

Central nervous system disorders and damage: Implications for stress, anxiety, and depression

2007 ◽  
Author(s):  
P. S. Seibert ◽  
P. D. Parker ◽  
C. M. Patterson ◽  
N. Whitener ◽  
J. O'Donnell ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Anxiety And Depression ◽  
Central Nervous System Disorders
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