Recent Advances in Delivery Through the Blood-Brain Barrier

2014 ◽  
Vol 14 (9) ◽  
pp. 1148-1160 ◽  
Author(s):  
Jessica Larsen ◽  
Douglas Martin ◽  
Mark Byrne
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Recent Advances

scholarly journals Brain Metastasis Treatment: The Place of Tyrosine Kinase Inhibitors and How to Facilitate Their Diffusion across the Blood–Brain Barrier

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1446
Author(s):  
Eurydice Angeli ◽  
Guilhem Bousquet
Keyword(s):  
Brain Metastases ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Blood Brain Barrier ◽  
Kinase Inhibitors ◽  
Brain Barrier ◽  
Molecular Alterations ◽  
Blood Brain ◽  
Recent Advances ◽  
Breast Cancer Brain Metastases

The incidence of brain metastases has been increasing constantly for the last 20 years, because of better control of metastases outside the brain, and the failure of most drugs to cross the blood–brain barrier at relevant pharmacological concentrations. Recent advances in the molecular biology of cancer have led to the identification of numerous molecular alterations, some of them targetable with the development of specific targeted therapies, including tyrosine kinase inhibitors. In this narrative review, we set out to describe the state-of-the-art in the use of tyrosine kinase inhibitors for the treatment of melanoma, lung cancer, and breast cancer brain metastases. We also report preclinical and clinical pharmacological data on brain exposure to tyrosine kinase inhibitors after oral administration and describe the most recent advances liable to facilitate their penetration of the blood–brain barrier at relevant concentrations and limit their physiological efflux.

scholarly journals Delivery of siRNA into the blood–brain barrier: recent advances and future perspective

2012 ◽  
Vol 3 (4) ◽  
pp. 417-420 ◽  
Author(s):  
Hiroya Kuwahara ◽  
Takanori Yokota ◽  
Hidehiro Mizusawa
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Future Perspective ◽  
Blood Brain ◽  
Recent Advances
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