Interrupting the Natural History of Diabetes Mellitus: Lifestyle, Pharmacological and Surgical Strategies Targeting Disease Progression

2014 ◽  
Vol 12 (1) ◽  
pp. 155-167 ◽  
Author(s):  
Kaivan Khavandi ◽  
Jack Brownrigg ◽  
Mohammed Hankir ◽  
Harpreet Sood ◽  
Naveed Younis ◽  
...  
2021 ◽  
Vol 10 (6) ◽  
pp. 1161
Author(s):  
Raluca Pais ◽  
Thomas Maurel

The epidemiology and the current burden of chronic liver disease are changing globally, with non-alcoholic fatty liver disease (NAFLD) becoming the most frequent cause of liver disease in close relationship with the global epidemics of obesity, type 2 diabetes and metabolic syndrome. The clinical phenotypes of NAFLD are very heterogeneous in relationship with multiple pathways involved in the disease progression. In the absence of a specific treatment for non-alcoholic steatohepatitis (NASH), it is important to understand the natural history of the disease, to identify and to optimize the control of factors that are involved in disease progression. In this paper we propose a critical analysis of factors that are involved in the progression of the liver damage and the occurrence of extra-hepatic complications (cardiovascular diseases, extra hepatic cancer) in patients with NAFLD. We also briefly discuss the impact of the heterogeneity of the clinical phenotype of NAFLD on the clinical practice globally and at the individual level.


1991 ◽  
Vol 164 (6) ◽  
pp. 1500-1513 ◽  
Author(s):  
James N. Martin ◽  
Pamela G. Blake ◽  
Kenneth G. Perry ◽  
James F. McCaul ◽  
L. Wayne Hess ◽  
...  

2019 ◽  
Vol 156 (6) ◽  
pp. S-1445
Author(s):  
Timothy J. Vreeland ◽  
Timothy E. Newhook ◽  
Laura R. Prakash ◽  
Whitney L. Dewhurst ◽  
Morgan L. Bruno ◽  
...  

1994 ◽  
Vol 39 (8) ◽  
pp. 1704-1707 ◽  
Author(s):  
Giuseppe Del Favero ◽  
Alessandro Caroli ◽  
Tamara Meggiato ◽  
Antonio Volpi ◽  
Paola Scalon ◽  
...  

1987 ◽  
Vol 29 (1) ◽  
pp. 38-46 ◽  
Author(s):  
Z. Laron ◽  
M. Karp ◽  
P. Fainmesser ◽  
S. Assa ◽  
Y. Aurbach

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