Solvent-free Mechano-chemical Synthesis of New Omeprazole Derived Metal Complexes: Characterization, Urease Inhibitory Kinetics and Selective Anti-Helicobacter pylori Activity

2018 ◽  
Vol 15 (3) ◽  
Author(s):  
Muhammad Amin ◽  
Farooq Anwar ◽  
Mahmood Anwar ◽  
Abdul Karim ◽  
Khalid M. Alkharfy ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Chemical Synthesis ◽  
Metal Complexes ◽  
Solvent Free ◽  
Urease Inhibitory

Efficient solvent-free fixation of CO2 catalyzed by new recyclable bifunctional metal complexes

2018 ◽  
Vol 24 ◽  
pp. 1-9 ◽  
Author(s):  
Jing Peng ◽  
Hai-Jian Yang ◽  
Sheng Wang ◽  
Binru Ban ◽  
Zidong Wei ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Solvent Free

scholarly journals Growth-Inhibiting, Bactericidal, Antibiofilm, and Urease Inhibitory Activities of Hibiscus rosa sinensis L. Flower Constituents toward Antibiotic Sensitive- and Resistant-Strains of Helicobacter pylori

ACS Omega ◽  
2020 ◽  
Vol 5 (32) ◽  
pp. 20080-20089 ◽  
Author(s):  
Hieu Tran Trung ◽  
Hoa Truong Thi Huynh ◽  
Linh Nguyen Thi Thuy ◽  
Hoang Nguyen Van Minh ◽  
My-Nuong Thi Nguyen ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Hibiscus Rosa Sinensis ◽  
Resistant Strains ◽  
Inhibitory Activities ◽  
Urease Inhibitory ◽  
Growth Inhibiting

Anti-Helicobacter pylori and urease inhibitory activities of resveratrol and red wine

2011 ◽  
Vol 44 (4) ◽  
pp. 964-969 ◽  
Author(s):  
Luísa Paulo ◽  
Mónica Oleastro ◽  
Eugenia Gallardo ◽  
João António Queiroz ◽  
Fernanda Domingues
Keyword(s):  
Helicobacter Pylori ◽  
Red Wine ◽  
Inhibitory Activities ◽  
Urease Inhibitory

scholarly journals Synthesis, In Silico Studies, and Evaluation of Syn and Anti Isomers of N-Substituted Indole-3-carbaldehyde Oxime Derivatives as Urease Inhibitors against Helicobacter pylori

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6658
Author(s):  
Ishani P. Kalatuwawege ◽  
Medha J. Gunaratna ◽  
Dinusha N. Udukala
Keyword(s):  
Helicobacter Pylori ◽  
Gastrointestinal Tract ◽  
In Silico ◽  
Hydroxylamine Hydrochloride ◽  
In Silico Studies ◽  
Urease Enzyme ◽  
Oxime Derivatives ◽  
Urease Inhibitory ◽  
H Pylori

Gastrointestinal tract infection caused by Helicobacter pylori is a common virulent disease found worldwide, and the infection rate is much higher in developing countries than in developed ones. In the pathogenesis of H. pylori in the gastrointestinal tract, the secretion of the urease enzyme plays a major role. Therefore, inhibition of urease is a better approach against H. pylori infection. In the present study, a series of syn and anti isomers of N-substituted indole-3-carbaldehyde oxime derivatives was synthesized via Schiff base reaction of appropriate carbaldehyde derivatives with hydroxylamine hydrochloride. The in vitro urease inhibitory activities of those derivatives were evaluated against that of Macrotyloma uniflorum urease using the modified Berthelot reaction. Out of the tested compounds, compound 8 (IC50 = 0.0516 ± 0.0035 mM) and compound 9 (IC50 = 0.0345 ± 0.0008 mM) were identified as the derivatives with potent urease inhibitory activity with compared to thiourea (IC50 = 0.2387 ± 0.0048 mM). Additionally, in silico studies for all oxime compounds were performed to investigate the binding interactions with the active site of the urease enzyme compared to thiourea. Furthermore, the drug-likeness of the synthesized oxime compounds was also predicted.

scholarly journals Mechanochemistry for facilitated access to N,N-diaryl NHC metal complexes

2017 ◽  
Vol 41 (3) ◽  
pp. 1057-1063 ◽  
Author(s):  
Audrey Beillard ◽  
Xavier Bantreil ◽  
Thomas-Xavier Métro ◽  
Jean Martinez ◽  
Frédéric Lamaty
Keyword(s):  
Metal Complexes ◽  
Ball Mill ◽  
Palladium Complexes ◽  
Solvent Free ◽  
Solvent Free Synthesis

A solvent-free synthesis of NHC–silver, gold, copper and palladium complexes in a ball-mill was achieved.

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