Skin involvement in paediatric patients with type 1 diabetes

2021 ◽  
Vol 17 ◽  
Author(s):  
Stefano Passanisi ◽  
Giuseppina Salzano ◽  
Fortunato Lombardo
Keyword(s):  
Type 1 Diabetes ◽  
Skin Diseases ◽  
Diagnostic Techniques ◽  
Skin Involvement ◽  
Skin Reactions ◽  
Paediatric Patients ◽  
Pubmed Database ◽  
Paediatric Age ◽  
Dermatological Side Effects

: Skin involvement is an overlooked aspect in the management of paediatric patients with type 1 diabetes. A comprehensive search of published literature using the PubMed database was carried out using the following key terms: “children”, “pediatric/paediatric patients”, “skin”, “skin disorders”, “type 1 diabetes”. Dermatological side effects are frequently observed among diabetic children and adolescents. Insulin-induced lipodystrophies and allergic contact dermatitis caused by insulin pumps or glycaemic sensors are the most common skin reactions in these patients. Furthermore, several diabetes-associated skin diseases such as necrobiosis lipoidica, granuloma annulare, vitiligo, and bullosis diabeticorum may already be present in paediatric age. Paediatric diabetes specialists should pay attention to their patients’ skin so as to recognize these disorders, identify the potential causes, and choose the most suitable treatment. Finally, the evaluation of skin concentrations of advanced glycation end-products using non-invasive diagnostic techniques may be used to assess the risk of chronic complications of diabetes as early as adolescence.

scholarly journals Skin Involvement in Paediatric Patients with Type 1 Diabetes

2021 ◽  
Author(s):  
Stefano Passanisi ◽  
Giuseppina Salzano ◽  
Fortunato Lombardo
Keyword(s):  
Type 1 Diabetes ◽  
Skin Diseases ◽  
Diagnostic Techniques ◽  
Skin Involvement ◽  
Skin Reactions ◽  
Paediatric Patients ◽  
Pubmed Database ◽  
Paediatric Age ◽  
Dermatological Side Effects

Skin involvement is an overlooked aspect in the management of paediatric patients with type 1 diabetes. A comprehensive search of published literature using the PubMed database was carried out using the following key terms: “children”, “pediatric/paediatric patients”, “skin”, “skin disorders”, “type 1 diabetes”. Dermatological side effects are frequently observed among diabetic children and adolescents. Insulin-induced lipodystrophies and allergic contact dermatitis caused by insulin pumps or glycaemic sensors are the most common skin reactions in these patients. Furthermore, several diabetes-associated skin diseases such as necrobiosis lipoidica, granuloma annulare, vitiligo, and bullosis diabeticorum may already be present in paediatric age. Paediatric diabetes specialists should pay attention to their patients’ skin so as to recognize these disorders, identify the potential causes, and choose the most suitable treatment. Finally, the evaluation of skin concentrations of advanced glycation end-products using non-invasive diagnostic techniques may be used to assess the risk of chronic complications of diabetes as early as adolescence.

scholarly journals Prevalence and risk of appearence of skin lesions considered to be cutaneous markers of diabetes in a population group in bihor county

2012 ◽  
Vol 19 (3) ◽  
pp. 285-290
Author(s):  
Denisa Kovacs ◽  
Luiza Demian ◽  
Aurel Babeş
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Skin Lesion ◽  
Skin Diseases ◽  
Population Group ◽  
Skin Lesions ◽  
Diabetic Patients ◽  
Cutaneous Lesions

Abstract Objectives: The aim of the study was to calculate the prevalence rates and risk ofappearance of cutaneous lesions in diabetic patients with both type-1 and type-2diabetes. Material and Method: 384 patients were analysed, of which 47 had type-1diabetes (T1DM), 140 had type-2 diabetes (T2DM) and 197 were non-diabeticcontrols. Results: The prevalence of the skin lesions considered markers of diabeteswas 57.75% in diabetics, in comparison to 8.12% in non-diabetics (p<0.01). The riskof skin lesion appearance is over 7 times higher in diabetic patients than in nondiabetics.In type-1 diabetes the prevalence of skin lesions was significantly higherthan in type-2 diabetes, and the risk of skin lesion appearance is almost 1.5 timeshigher in type-1 diabetes than type-2 diabetes compared to non-diabetic controls.Conclusions: The diabetic patients are more susceptible than non-diabetics todevelop specific skin diseases. Patients with type-1 diabetes are more affected.

High Prevalence of Skin Reactions Among Pediatric Patients with Type 1 Diabetes Using New Technologies: The Alarming Role of Colophonium

2020 ◽  
Vol 22 (1) ◽  
pp. 53-56 ◽  
Author(s):  
Fortunato Lombardo ◽  
Stefano Passanisi ◽  
Lucia Caminiti ◽  
Andrea Barbalace ◽  
Alessandra Marino ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Pediatric Patients ◽  
New Technologies ◽  
Skin Reactions ◽  
High Prevalence

scholarly journals The Role of SGLT-2 Inhibitors as an Adjuvant to Insulin Therapy in Type-1 Diabetes Mellitus- Literature Review

2021 ◽  
pp. 333-337
Author(s):  
Sultan Ali Alshehri ◽  
Sultan Abdulwahab M. Asiri ◽  
Aalaa Mohammad Algarni ◽  
Manal Mohammed Alamari
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Body Weight ◽  
Insulin Therapy ◽  
Type 1 Diabetes Mellitus ◽  
Insulin Regimen ◽  
Increase Body Weight ◽  
Pubmed Database

Background: Type 1 diabetes mellitus is the main risk factor for cardiovascular complications. Therefore, intensified insulin therapy might be needed to achieve better glycemic control in some patients. However, insulin therapy might lead to increase body weight and induce hypoglycemia. Increase body weight is directly correlated to insulin resistance, the main factor for cardiovascular risk.  Objective: To assess the effectiveness of adding SGLT2 inhibitors to insulin therapy in type 1 diabetes mellitus.  Methods: We searched in the PubMed database looking for relevant articles on the topic. We used Mesh words search, including SGLT2 inhibitor, sotagliflozin, type 1 diabetes mellitus, insulin treatment.  Conclusion: Adding oral antidiabetic agents, such as SGLT2 or dual SGLT inhibitors to insulin regimen might be beneficial in improving insulin resistance. Thus, it achieved better insulin resistance by decrease daily insulin requirements and bodyweight control, leading to better cardiovascular outcomes among Type-1 diabetes patients.

The Impact of Pregnancy and Parity on Type 1 Diabetes Complications

2019 ◽  
Vol 15 (6) ◽  
pp. 429-434
Author(s):  
Monika Zurawska-Klis ◽  
Katarzyna Cypryk
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Complications ◽  
Diabetic Complication ◽  
Current Data ◽  
Short Term ◽  
Chronic Complications ◽  
Pubmed Database ◽  
The Subject ◽  
The Impact

Background: The potential influence of pregnancy and parity on the risk of chronic diabetic complications is a matter of great concern and constant discussion. This aspect seems relevant and should be the subject of thorough discussion with the woman planning childbirth. Introduction: Current data concerning the impact of pregnancy and parity covers primarily retinopathy and nephropathy, while the aspects of neuropathy and macrovascular complications are unsatisfactorily documented. Majority of studies focus on single complication only, while the number of papers assessing this problem in a complex setting is limited. The available body of evidence concerns mainly the short-term impact of pregnancy on diabetic chronic complications while the data concerning the longer perspective are scarce. Moreover, the results found in the available literature are conflicting. The aim of the study was to summarize all available data concerning the longer impact of parity on the chronic complications in the women with type 1 diabetes. Methods: PubMed database has been searched between October 2013 and September 2018 and all relevant papers were selected. This review summarizes data on the impact of pregnancy and parity on chronic complications in type 1 diabetic women. Results: Current data assessing this matter in a complex way are limited, and the available results are controversial. It seems however that pregnancy itself may rather influence pre-existing diabetic complication than affect risk of its development. Additionally, evidence suggests that any deleterious changes appearing during pregnancy are transient and tend to remit after delivery. Conclusion: It seems that neither pregnancy nor parity affects the risk of diabetic chronic complications in the longer perspective.

Alteration of B cell subsets and the receptor for B cell activating factor (BAFF) in paediatric patients with type 1 diabetes

2017 ◽  
Vol 189 ◽  
pp. 94-100 ◽  
Author(s):  
Zuzana Parackova ◽  
Adam Klocperk ◽  
Michal Rataj ◽  
Jana Kayserova ◽  
Irena Zentsova ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
B Cell ◽  
B Cell Activating Factor ◽  
Paediatric Patients ◽  
B Cell Subsets

scholarly journals PO-234 Research progress of exercise therapy on type 1 diabetes mellitus

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Huayu Shang ◽  
Zhifei Ke ◽  
Zhi Xia
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Resistance Training ◽  
Type 1 Diabetes Mellitus ◽  
Exercise Therapy ◽  
Cell Function ◽  
Research Progress ◽  
Pubmed Database

Objective  Type 1 diabetes mellitus (T1DM) is an autoimmune disease with a clear genetic basis, and early islet cell function appears clearly in recession or even lost. Insulin deficiency allows patients to rely on exogenous insulin for life, and long-term complications seriously affect quality of life and shorten life expectancy.  Methods This paper retrieves 1998-2018 years' literatures on "Sports" and "type 1 diabetes" through the PubMed database, and collate and analyze the progress of the research and induction of type 1 diabetes exercise therapy. Results Numerous studies have shown that regular physical exercise can reduce the daily insulin dose in patients with T1DM.At the same time, they should master the contraindications in order to avoid the risks of movement. Currently a recommendation for all T1DM patients is engaging in at least 150 min/week of moderate to vigorous intensity aerobic exercise, sustainability or HIIT, combined with resistance training such as resistance machines and bands, as well as other stretching and balance exercises such as yoga, tai chi, 3 to 7 times per week which is depended on the physical condition of patients and exercise intensity, and resistance training can be performed on nonconsecutive days. Conclusions So patients need to be clear how to safely increase their physical activity, and incorporate more independent physical activity into daily life.  

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