Editorial (Hot Topic: Emerging Therapeutic Targets in Inflammation and Allergy Drug Discovery from Patent Perspective)

2013 ◽  
Vol 7 (2) ◽  
pp. 103-104 ◽  
Author(s):  
Anil K. Sharma
Keyword(s):  
Drug Discovery ◽  
Therapeutic Targets ◽  
Allergy Drug

Apoptosis: Potential Therapeutic Targets for New Drug Discovery

2007 ◽  
Vol 14 (22) ◽  
pp. 2369-2379 ◽  
Author(s):  
Snehasis Jana ◽  
Jyoti Paliwal
Keyword(s):  
Drug Discovery ◽  
Therapeutic Targets ◽  
New Drug

DUAL SPECIFICITY PROTEIN PHOSPHATASES: Therapeutic Targets for Cancer and Alzheimer's Disease

2005 ◽  
Vol 45 (1) ◽  
pp. 725-750 ◽  
Author(s):  
Alexander P. Ducruet ◽  
Andreas Vogt ◽  
Peter Wipf ◽  
John S. Lazo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Therapeutic Targets ◽  
Dual Specificity ◽  
Complete Sequencing ◽  
Dual Specificity Phosphatases ◽  
Molecular Therapeutic ◽  
Specificity Protein ◽  
Molecular Therapeutic Targets

The complete sequencing of the human genome is generating many novel targets for drug discovery. Understanding the pathophysiological roles of these putative targets and assessing their suitability for therapeutic intervention has become the major hurdle for drug discovery efforts. The dual-specificity phosphatases (DSPases), which dephosphorylate serine, threonine, and tyrosine residues in the same protein substrate, have important roles in multiple signaling pathways and appear to be deregulated in cancer and Alzheimer's disease. We examine the potential of DSPases as new molecular therapeutic targets for the treatment of human disease.

Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery

2019 ◽  
Vol 63 (10) ◽  
pp. 5013-5030 ◽  
Author(s):  
Jian Li ◽  
Yang Ge ◽  
Jun-Xiang Huang ◽  
Kristian Strømgaard ◽  
Xiaolei Zhang ◽  
...  
Keyword(s):  
Drug Discovery ◽  
G Proteins ◽  
Therapeutic Targets ◽  
Heterotrimeric G Proteins
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