Intralipid-Based Phantoms for the Development of New Optical Diagnostic Techniques

Intralipid is a material widely employed for the preparation of phantoms for optical imaging and biophotonics applications in medical field. The development of new optical diagnostic equipment in these fields requires the use of well-designed phantoms with optical properties (including scattering and absorption) mimicking those of biological tissues in all the pre-clinical stages of investigations. For this reason, great research effort has been devoted to optically characterize Intralipid and at preparing optimal phantoms. In this short review, we summarize the principal physico-chemical characteristics of Intralipid and the main contributions in the assessment of its scattering and absorption properties. In addition, the most largely used Intralipid-based homogeneous and non-homogeneous phantoms are discussed. Even though other materials are available for the preparation of phantoms, the use of Intralipid still offers an inexpensive and easy-to-use method for preparing phantoms with finely tuned optical properties.

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Zur Entstehung primärer Gasentladungszonen bei elektrischen Drahtexplosionen / On the Formation of Gas Discharge Zones in Electrical Wire Explosions

Zeitschrift für Naturforschung A ◽

10.1515/zna-1972-1109 ◽

1972 ◽

Vol 27 (11) ◽

pp. 1586-1596

Author(s):

Helmut Jäger

Keyword(s):

Short Review ◽

Diagnostic Techniques ◽

Gas Discharge ◽

Discharge Circuit ◽

Electrical Wire ◽

Gas Discharges ◽

Optical Diagnostic ◽

Wire Material ◽

The Wire

Abstract Electrical explosions of wires in a conventional condenser discharge circuit have been investigated by correlated electrical and optical diagnostic techniques. Variations of the circuit parameters show details of the explosion phenomena which cause early ignitions of gas discharges at restricted regions of the wire. Under normal conditions these discharges lead to inhomogeneities of the explosion column and prevent further heating of the wire material. A short review about the phenomena is given.

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Remote sensing of coal-fired MHD by optical diagnostic techniques

10.2514/6.1983-469 ◽

1983 ◽

Author(s):

D. MURPHREE ◽

R. COOK ◽

W. SHEPARD ◽

L. BAUMAN ◽

J. GASSAWAY ◽

...

Keyword(s):

Remote Sensing ◽

Diagnostic Techniques ◽

Optical Diagnostic

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Machine learning estimation of tissue optical properties

Scientific Reports ◽

10.1038/s41598-021-85994-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Brett H. Hokr ◽

Joel N. Bixler

Keyword(s):

Neural Network ◽

Optical Properties ◽

Biological Tissues ◽

Homogeneous Layer ◽

In Vivo Measurement ◽

Tissue Optical Properties ◽

The Neural Network ◽

Spatio Temporal ◽

Fully Connected

AbstractDynamic, in vivo measurement of the optical properties of biological tissues is still an elusive and critically important problem. Here we develop a technique for inverting a Monte Carlo simulation to extract tissue optical properties from the statistical moments of the spatio-temporal response of the tissue by training a 5-layer fully connected neural network. We demonstrate the accuracy of the method across a very wide parameter space on a single homogeneous layer tissue model and demonstrate that the method is insensitive to parameter selection of the neural network model itself. Finally, we propose an experimental setup capable of measuring the required information in real time in an in vivo environment and demonstrate proof-of-concept level experimental results.

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The Light Absorption Properties of Cu2S Nanowire Arrays

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.528.272 ◽

2012 ◽

Vol 528 ◽

pp. 272-276 ◽

Cited By ~ 4

Author(s):

Shan Ren ◽

Li Qiang Li ◽

Zhu Feng Liu ◽

Ming Li ◽

Lan Hong

Keyword(s):

Optical Properties ◽

Distribution Density ◽

Photovoltaic Cell ◽

Nanowire Arrays ◽

Band Gaps ◽

Infrared Light ◽

Infrared Band ◽

Absorption Properties ◽

Potential Applications ◽

Cu Foil

Cu2S nanowire arrays with different morphologies were prepared by solid-gas reaction between Cu foil and mixture gas of H2S and O2. Their microstructures were observed with XRD, TEM, and the optical properties were measured by DRS, PL and Raman. The results showed that the nanowire were Cu2S single crystal with a thin layer CuxO (x=1, 2) over the surface. The optical properties of the Cu2S nanowire arrays are related to the diameter, length, and distribution density of nanowire arrays. The thinner is the nanowire’s diameter; the bigger is the absorption of the visible light, and the absorbance begun to descend within infrared band. The absorbance of nanowire arrays with bigger diameter to the infrared light was stronger than that with thinner diameter. The photoluminescence spectrum (PL) indicated that band gaps of Cu2S nanowire arrays also changed simultaneously with the nanowire arrays’ structure parameters. The research demonstrated the Cu2S nanowire arrays’ potential applications in the photovoltaic cell and solar-heat harvesting area.

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Discovering new 3D bioprinting applications: Analyzing the case of optical tissue phantoms

International Journal of Bioprinting ◽

10.18063/ijb.v5i1.178 ◽

2018 ◽

Vol 5 (1) ◽

Author(s):

Marisela Rodriguez-Salvador

Keyword(s):

Optical Properties ◽

3D Printing ◽

Clinical Training ◽

Three Dimensional ◽

Biological Tissues ◽

3D Bioprinting ◽

Technology Intelligence ◽

Biomedical Device ◽

Tissue Phantoms ◽

Scientific Papers

Optical tissue phantoms enable to mimic the optical properties of biological tissues for biomedical device calibration, new equipment validation, and clinical training for the detection, and treatment of diseases. Unfortunately, current methods for their development present some problems, such as a lack of repeatability in their optical properties. Where the use of three-dimensional (3D) printing or 3D bioprinting could address these issues. This paper aims to evaluate the use of this technology in the development of optical tissue phantoms. A competitive technology intelligence methodology was applied by analyzing Scopus, Web of Science, and patents from January 1, 2000, to July 31, 2018. The main trends regarding methods, materials, and uses, as well as predominant countries, institutions, and journals, were determined. The results revealed that, while 3D printing is already employed (in total, 108 scientific papers and 18 patent families were identified), 3D bioprinting is not yet applied for optical tissue phantoms. Nevertheless, it is expected to have significant growth. This research gives biomedical scientists a new window of opportunity for exploring the use of 3D bioprinting in a new area that may support testing of new equipment and development of techniques for the diagnosis and treatment of diseases.

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Measurement of the Optical Properties of Muscle Tissue In Vivo

10.1115/imece2000-2214 ◽

2000 ◽

Author(s):

P. L. Kopsombut ◽

D. Willis ◽

A. E. Schen ◽

L. X. Xu ◽

X. Xu

Keyword(s):

Optical Properties ◽

Transport Theory ◽

Rapid Development ◽

Ccd Camera ◽

High Sensitivity ◽

Biological Tissues ◽

In Vivo Measurement ◽

Living Tissues

Abstract Along with rapid development of diagnostic and therapeutic applications of lasers in medicine, optical properties of various biological tissues have been extensively studied [1]. Most of the studies were performed in vitro owing to the complexity involved in in vivo measurement. To date, it is well understood that living tissue is an absorbing and scattering heterogeneous medium because of its complex structures including blood network. The transport theory cannot be readily used due to the heterogeneity and the absence of the optical properties of living tissues [2]. In this research, we have developed a procedure for measuring the total attenuation coefficient (μ1) of the exteriorized rat 2-D spinotrapezius muscle in the wavelength ranged from 480–560 nm using the collimated light from a Nitrogen-pumped dye laser and a high-sensitivity CCD camera.

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Introduction to Combustion Simulations and Optical Diagnostic Techniques for Internal Combustion Engines

Energy, Environment, and Sustainability - Simulations and Optical Diagnostics for Internal Combustion Engines ◽

10.1007/978-981-15-0335-1_1 ◽

2019 ◽

pp. 3-6

Author(s):

Akhilendra Pratap Singh ◽

Pravesh Chandra Shukla ◽

Joonsik Hwang ◽

Avinash Kumar Agarwal

Keyword(s):

Internal Combustion Engines ◽

Internal Combustion ◽

Diagnostic Techniques ◽

Combustion Engines ◽

Optical Diagnostic

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Optical Diagnostic Based on Functionalized Gold Nanoparticles

International Journal of Molecular Sciences ◽

10.3390/ijms20184346 ◽

2019 ◽

Vol 20 (18) ◽

pp. 4346 ◽

Cited By ~ 12

Author(s):

Jiemei Ou ◽

Zidan Zhou ◽

Zhong Chen ◽

Huijun Tan

Keyword(s):

Optical Properties ◽

Future Perspective ◽

Au Nps ◽

Optical Diagnostic ◽

Surface Enhanced ◽

Surface Enhanced Raman ◽

Enhanced Raman Scattering ◽

Diagnostic Applications

Au nanoparticles (NPs) possess unique physicochemical and optical properties, showing great potential in biomedical applications. Diagnostic spectroscopy utilizing varied Au NPs has become a precision tool of in vitro and in vivo diagnostic for cancer and other specific diseases. In this review, we tried to comprehensively introduce the remarkable optical properties of Au NPs, including localized surfaces plasmon resonance (LSPR), surface-enhanced Raman scattering (SERS), and metal-enhanced fluorescence (MEF). Then, we highlighted the excellent works using Au NPs for optical diagnostic applications. Ultimately, the challenges and future perspective of using Au NPs for optical diagnostic were discussed.

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