Bone Substitutes as a Drug Delivery of Antibiotics

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.631.321 ◽

2014 ◽

Vol 631 ◽

pp. 321-325

Author(s):

Cornelia Ganz ◽

Thomas Gerber

Keyword(s):

Drug Delivery ◽

Bone Disease ◽

Detection System ◽

Aminoglycoside Antibiotic ◽

Bone Substitutes ◽

Bone Graft Substitute ◽

Antibiotic Concentration ◽

Synthetic Bone ◽

Synthetic Bone Graft

The aim of the present study was the in vitro investigation of a synthetic bone graft substitute loaded with individual antibiotics for the treatment of osteomyelitis and infectious bone disease. The elution of gentamicin, an aminoglycoside antibiotic, from the NanoBone® products NanoBone® S granules (NBG) and lyophilized NanoBone® (NBP) putty was tested over a period of one week. An indirect photometrically-based detection system was used to measure the released antibiotic concentration. Both materials showed very different release behaviour. After one day lyophilized NanoBone® putty delivered 100% of the gentamicin value, whereas NanoBone® S granules released one-fifth of the used gentamicin level.

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In Vitro Elution Characteristics of Gentamicin and Vancomycin from Synthetic Bone Graft Substitutes

The Open Orthopaedics Journal ◽

10.2174/1874325001307010624 ◽

2013 ◽

Vol 7 (1) ◽

pp. 624-629 ◽

Cited By ~ 5

Author(s):

Gerrit Steffen Maier ◽

Klaus Edgar Roth ◽

Stefan Andereya ◽

Klaus Birnbaum ◽

Christopher Niedhart ◽

...

Keyword(s):

Bone Graft ◽

Bone Disease ◽

Detection Threshold ◽

Vancomycin Concentration ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Homogeneous Particle ◽

Bone Graft Substitutes ◽

New Treatment

Objects: Beta tricalciumphosphate pellets loaded with individualized antibiotics may represent novel options in the treatment of osteomyelitis and infectious bone disease. Here, the in vitro antibiotic elution of vancomycin and gentamicin from the synthetic bone graft substitutes Cerasorb® and Cerasorb M® was tested. Methods: Antibiotic elution and concentration of gentamcin and vancomycin were measured using photometrically-based measurement and homogeneous particle-enhanced turbidimetric inhibition immunoassays (PETINIA). Results: Initially both materials showed a high release of the loaded antibiotics, with Cerasorb M® showing lower release levels for gentamicin and vancomycin than Cerasorb®. Gentamicin concentrations of Cerasorb M granules and Cerasorb were below the minimum detectiontreshold until day four and six of the experiment respectively. The vancomycin release-level followed a similar pattern, although the vancomycin concentration eluted by Cerasorb M® granules stayed above the detection threshold during the experimental time. Conclusions: Cerasorb® and Cersorb M® may represent a new treatment option in osteomyelitis and infectious bone disease.

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The New Art of Bone Graft Substitute Design

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.330-332.959 ◽

2007 ◽

Vol 330-332 ◽

pp. 959-962

Author(s):

Ernst Dieter Klinkenberg ◽

Hans Georg Neumann ◽

Ulrike Bulnheim ◽

Joachim Rychly

Keyword(s):

Bone Graft ◽

Bone Graft Substitute ◽

Graft Material ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Vital Cell ◽

Design And Manufacturing ◽

Bone Graft Substitutes ◽

First Time

A new method of design and manufacturing of bone graft substitutes is introduced. For the first time it is possible to prepare bone graft substitutes with a directed and controlled pore structure. Furthermore, the formation of sophisticated geometries is feasible. First in vitro investigations with cell cultures show a vital cell growing on the synthetic bone graft material. Numerous applications are possible.

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405 Radiological Analysis of Gentamicin Eluting Synthetic Bone Graft Substitute Used in The Management of Gustilo IIIB Open Fractures

British Journal of Surgery ◽

10.1093/bjs/znab134.273 ◽

2021 ◽

Vol 108 (Supplement_2) ◽

Author(s):

A Aljawadi ◽

I Madhi ◽

T Naylor ◽

M Elmajee ◽

A Islam ◽

...

Keyword(s):

Bone Graft ◽

Cortical Thickness ◽

Bone Graft Substitute ◽

Fracture Site ◽

Open Fractures ◽

X Rays ◽

Radiographic Images ◽

Synthetic Bone ◽

Synthetic Bone Graft

Abstract Background Management of traumatic bone void associated with Gustilo IIIB open fractures is challenging. Gentamicin eluting synthetic bone graft substitute (Cerament-G) had been recently utilised for the management of patients with these injuries. This study aims to assess radiological signs of Cerament-G remodelling. Method Retrospective data analysis of all patients admitted to our unit with IIIB open fractures who had Cerament-G applied as avoid filler. Postoperative radiographic images of the fracture site at 6-weeks, 3-months, 6-months and at the last follow-up were reviewed. The radiological signs of Cerament-G integration, percent of void healing, and bone cortical thickness at the final follow-up were assessed. Results 34 patients met our inclusion criteria, mean age: 42 years. Mean follow-up time was 20 months. 59% of patients had excellent (>90%) void filling, 26.4% of patients had 50-90% void filling, and 14.6% had < 50% void filling. Normal bone cortical thickness was restored on AP and Lateral views in 55.8% of patients. No residual Cerement-G was seen on X-rays at the final follow-up in any of the patients. Conclusions Our results showed successful integration of Cerament-G with excellent void filling and normal cortical thickness achieved in more than half of the patients.

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Test yourself answer: supra-acetabular pelvis synthetic bone graft substitute (CERAMENT) with expected resorption of radiopaque graft material

Skeletal Radiology ◽

10.1007/s00256-020-03431-x ◽

2020 ◽

Vol 49 (8) ◽

pp. 1329-1330

Author(s):

Molly B. Carnahan ◽

Jeremiah R. Long

Keyword(s):

Bone Graft ◽

Bone Graft Substitute ◽

Graft Material ◽

Synthetic Bone ◽

Synthetic Bone Graft

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Suitability of zinc-based bioceramic for repair of bone defects

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100141068 ◽

1995 ◽

Vol 53 ◽

pp. 938-939

Author(s):

C. Taylor ◽

B. Mehling ◽

A. Longo ◽

D. Snead ◽

D. Reynolds ◽

...

Keyword(s):

Endochondral Ossification ◽

Fibrous Tissue ◽

Bone Defects ◽

Bone Graft Substitute ◽

Serial Sections ◽

Synthetic Material ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Immunological Rejection ◽

Cell Processes

The advantages of a synthetic bone-graft substitute include reduction of risks due to immunological rejection and transmission of diseases, such as AIDS. A satisfactory synthetic material must be non-toxic, allow adequate re-vascularization, and be capable of bearing weight and tolerating strain. Our experiments using a resorpable, zinccalcium- phosphorous-ceramic oxide (ZCAP) in composite with malic acid, vitamin E, and gentamicin sulfate, indicate that this zincbased bioceramic implant fulfills the requirements of an osteoconductive filler between two fractured ends of rat femurs.Assessment of the suitability of ZCAP involved the following techniques : 1) Radiological examination showing the position of the implant, bridging of the defect with bone, and dissolution of the bioceramic. 2) Histology of serial sections indicating resorption of the ZCAP (a few granules remain after 10 weeks) and replacement by endochondral ossification. 3) Scanning electron microscopy revealing that the intact ZCAP first becomes surrounded by fibrous tissue and then infiltrated by cell processes.

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