Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure

Objectives: We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF). Methods: We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses. Results: Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results. Conclusion: Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility

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Economic Evaluation of an N-terminal Pro B-type Natriuretic Peptide-Supported Diagnostic Strategy Among Dyspneic Patients Suspected of Acute Heart Failure in the Emergency Department

The American Journal of Cardiology ◽

10.1016/j.amjcard.2021.01.036 ◽

2021 ◽

Vol 147 ◽

pp. 61-69 ◽

Cited By ~ 1

Author(s):

Uwe Siebert ◽

Sandra Milev ◽

Denise Zou ◽

Michal Litkiewicz ◽

Hannah K. Gaggin ◽

...

Keyword(s):

Heart Failure ◽

Emergency Department ◽

Economic Evaluation ◽

Acute Heart Failure ◽

Natriuretic Peptide ◽

Diagnostic Strategy

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Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: The NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial

European Journal of Heart Failure ◽

10.1093/eurjhf/hfr087 ◽

2011 ◽

Vol 13 (8) ◽

pp. 846-851 ◽

Cited By ~ 175

Author(s):

Alan S. Maisel ◽

Christian Mueller ◽

Robert Fitzgerald ◽

Robert Brikhan ◽

Brian C. Hiestand ◽

...

Keyword(s):

Heart Failure ◽

Acute Heart Failure ◽

Natriuretic Peptide ◽

Decompensated Heart Failure ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Acutely Decompensated Heart Failure ◽

Prognostic Utility ◽

Neutrophil Gelatinase

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Mid-regional atrial natriuretic peptide and C-terminal pro-endothelin-1 for early diagnosis of acute heart failure in unselected older patients presenting to the emergency department

European Heart Journal ◽

10.1093/eurheartj/eht308.1722 ◽

2013 ◽

Vol 34 (suppl 1) ◽

pp. 1722-1722

Author(s):

P. Bahrmann ◽

T. Bertsch ◽

A. Bahrmann ◽

M. Christ ◽

S. Achenbach ◽

...

Keyword(s):

Heart Failure ◽

Emergency Department ◽

Early Diagnosis ◽

Atrial Natriuretic Peptide ◽

Acute Heart Failure ◽

Natriuretic Peptide ◽

Older Patients ◽

Endothelin 1 ◽

Atrial Natriuretic

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B-Type Natriuretic Peptide and Non-Invasive Haemodynamics and Hydration Status Assessments in the Management of Patients with Acute Heart Failure in the Emergency Department

High Blood Pressure & Cardiovascular Prevention ◽

10.2165/11587990-000000000-00000 ◽

2010 ◽

Vol 17 (4) ◽

pp. 219-225 ◽

Cited By ~ 6

Author(s):

Rossella Marino ◽

Laura Magrini ◽

Enrico Ferri ◽

Giulia Gagliano ◽

Salvatore Di Somma

Keyword(s):

Heart Failure ◽

Emergency Department ◽

Acute Heart Failure ◽

Natriuretic Peptide ◽

Hydration Status ◽

Non Invasive

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Faculty Opinions recommendation of Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717955329.793460484 ◽

2012 ◽

Author(s):

Jan Kielstein ◽

Oktay Tutarel

Keyword(s):

Heart Failure ◽

Acute Heart Failure ◽

Natriuretic Peptide ◽

Decompensated Heart Failure ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Acutely Decompensated Heart Failure ◽

Prognostic Utility ◽

Neutrophil Gelatinase

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Association of atrial fibrillation and amino-terminal pro–brain natriuretic peptide concentrations in dyspneic subjects with and without acute heart failure: Results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) study

American Heart Journal ◽

10.1016/j.ahj.2006.10.005 ◽

2007 ◽

Vol 153 (1) ◽

pp. 90-97 ◽

Cited By ~ 48

Author(s):

Angela Morello ◽

Donald M. Lloyd-Jones ◽

Claudia U. Chae ◽

Roland R.J. van Kimmenade ◽

Annabel C. Chen ◽

...

Keyword(s):

Heart Failure ◽

Atrial Fibrillation ◽

Emergency Department ◽

Brain Natriuretic Peptide ◽

Acute Heart Failure ◽

Natriuretic Peptide ◽

Amino Terminal ◽

Pride Study

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Broadcasting Not Properly: Using B-type Natriuretic Peptide Interval Likelihood Ratios and the Results of Other Emergency Department Tests to Diagnose Acute Heart Failure in Dyspneic Patients

Academic Emergency Medicine ◽

10.1111/acem.12918 ◽

2016 ◽

Vol 23 (3) ◽

pp. 347-350 ◽

Cited By ~ 3

Author(s):

Michael A. Kohn ◽

Brian Steinhart

Keyword(s):

Heart Failure ◽

Emergency Department ◽

Acute Heart Failure ◽

Natriuretic Peptide ◽

Likelihood Ratios

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Prognostic Value of Cysteine-Rich Protein 61 Combined with N-Terminal Pro-B-Type Natriuretic Peptide for Mortality in Acute Heart Failure Patients with and without Chronic Kidney Disease

Cardiorenal Medicine ◽

10.1159/000501929 ◽

2019 ◽

Vol 10 (1) ◽

pp. 11-21

Author(s):

Chen Liu ◽

Weihao Liang ◽

Xin He ◽

Marvin Owusu-Agyeman ◽

Zexuan Wu ◽

...

Keyword(s):

Heart Failure ◽

Chronic Kidney Disease ◽

Logistic Regression ◽

Renal Function ◽

Kidney Disease ◽

Acute Heart Failure ◽

Natriuretic Peptide ◽

Odds Ratio ◽

Prognostic Value ◽

Cysteine Rich Protein

Background: The ability of most biomarkers, such as N-terminal pro-B-type natriuretic peptide (NT-proBNP), to predict prognosis in heart failure can be affected by the state of renal function; therefore, there is the need for a biomarker that can predict prognosis accurately without the influence of renal function. The prognostic value of cysteine-rich protein 61 (CYR61/CCN1) in acute heart failure (AHF) patients has been proven. Methods: A total of 248 patients hospitalized with AHF were recruited in this study, and serum CCN1 levels, NT-proBNP levels, and other necessary data of patients were collected upon admission. The correlation of serum CCN1 with estimated glomerular filtration rate (eGFR) was investigated, and the logistic regression model was used to investigate the prognostic value of serum CCN1 for 3-month mortality. Results: Fifty-four of 248 patients died (21.8%) during a 3-month follow-up. Serum CCN1 had no significant correlation with eGFR (rho = –0.088, p = 0.167). In the overall population and patients without chronic kidney disease, results showed that both serum CCN1 and NT-proBNP were significantly associated with 3-month mortality. In patients with chronic kidney disease, serum CCN1 was significantly associated with 3-month mortality in logistic regression analysis (odds ratio = 2.40, p = 0.002) while NT-proBNP was not. Further in tertile group comparison, in patients with chronic kidney disease, higher tertile levels of serum CCN1 had a significantly higher risk of 3-month mortality compared to the lower tertile ones (odds ratio = 4.17, p = 0.013), but that of NT-proBNP did not. Conclusion: Serum CCN1 level is not associated with eGFR, and it maintains the prognostic value in AHF patients with chronic kidney disease. CCN1 could be a potential novel prognostic biomarker in AHF patients with chronic kidney disease.

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