scholarly journals Broadcasting Not Properly: Using B-type Natriuretic Peptide Interval Likelihood Ratios and the Results of Other Emergency Department Tests to Diagnose Acute Heart Failure in Dyspneic Patients

2016 ◽  
Vol 23 (3) ◽  
pp. 347-350 ◽  
Author(s):  
Michael A. Kohn ◽  
Brian Steinhart
2012 ◽  
Vol 5 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Queen Henry-Okafor ◽  
Sean P. Collins ◽  
Cathy A. Jenkins ◽  
Karen F. Miller ◽  
David J. Maron ◽  
...  

Objectives: We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF). Methods: We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses. Results: Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results. Conclusion: Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility


Author(s):  
Eleni Michou ◽  
Nikola Kozhuharov ◽  
Jasmin Martin ◽  
Christian Mueller

Acute dyspnoea is a very common symptom in the acute cardiac care setting. In contrast to current beliefs, acute dyspnoea, as the leading symptom, is associated with about twice the mortality risk, compared to acute chest pain. Rapid and accurate identification of the cause of dyspnoea is critical to the initiation of specific and effective treatment. In most patients, a rapid and accurate diagnosis in the emergency department can be achieved by a combination of vital signs, including pulse oximetry, detailed patient history, physical examination, blood tests including B-type natriuretic peptide or N-terminal pro-B type natriuretic peptide, venous blood gases, and C-reactive protein in all patients, and D-dimers in selected patients, electrocardiograms, chest X-ray and pleural and/or lung ultrasound. It is key to remember that the prevalence of acute heart failure in unselected patients with acute dyspnoea is about 50%. Therefore, a high awareness for the presence of acute heart failure is mandatory. Acute heart failure, pneumonia, obstructive pulmonary diseases (chronic obstructive pulmonary disease and asthma), pulmonary embolism, and anxiety disorders represent more than 90% of all cases with acute dyspnoea in the emergency department. In about 10-15%, two acute causes (e.g. acute heart failure and pneumonia) may be present and require combined treatment. Transthoracic echocardiography should be immediately performed in all patients with acute dyspnoea and shock, and in those patients in whom the diagnosis remains uncertain, even after initial work-up


2021 ◽  
Vol 28 (4) ◽  
pp. 146-152
Author(s):  
Rathika Rajah ◽  
Lim Kuan Yee ◽  
Ng Boon Hau ◽  
Soo Chun Ian

Acute dyspnea is one of the prevalent reasons for admission to the emergency department. The use of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as an adjunct for assessing acute dyspnea is not a common practice in many public hospitals in Malaysia. This retrospective review is part of our clinical audit to determine the utility of NT-proBNP as an adjunct to non- standardised clinical evaluation in identifying acute heart failure (HF) in patients with persistent dyspnea (24 h) post-admission. In this cohort of 30 patients with acute dyspnea, NT-proBNP was positive in 20 patients (87%) with acute HF. Three patients (13%) who were treated for septic shock recorded a NT-proBNP false-positive. NT-proBNP demonstrated an overall sensitivity of 90%, a specificity of 70%, a positive predictive value of 85.7% and a negative predictive value of 77.8% in identifying acute HF. These results reinforce that age-stratified NT-proBNP cut-off values are useful for ruling-in or -out acute HF. Thus, NT-proBNP should be considered a crucial point of care, testing to decifer the conundrum of acute dyspneic patients.


Sign in / Sign up

Export Citation Format

Share Document