scholarly journals Schisandrin B Enhances Glutathione Redox Cycling and Protects Against β-amyloid-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells: A Comparative Study of Various Phytochemicals

2014 ◽  
Vol 7 (1) ◽  
pp. 49-57 ◽  
Author(s):  
K. M. Ko ◽  
P. K. Leong ◽  
P. Y. Lam ◽  
N. Chen
Keyword(s):  
Comparative Study ◽  
Redox Cycling ◽  
Schisandrin B ◽  
Human Neuroblastoma ◽  
Β Amyloid ◽  
Induced Apoptosis ◽  
Glutathione Redox

Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells

BioFactors ◽  
2011 ◽  
Vol 37 (6) ◽  
pp. 439-446 ◽  
Author(s):  
Philip Y. Lam ◽  
Pou Kuan Leong ◽  
Na Chen ◽  
Kam Ming Ko
Keyword(s):  
Cultured Cells ◽  
Redox Cycling ◽  
Schisandrin B ◽  
Oxidant Injury ◽  
Different Types ◽  
Glutathione Redox

scholarly journals Schisandrin B Prevents Doxorubicin-Induced Cardiotoxicity via Enhancing Glutathione Redox Cycling

2007 ◽  
Vol 13 (22) ◽  
pp. 6753-6760 ◽  
Author(s):  
Ling Li ◽  
Qiangrong Pan ◽  
Weidong Han ◽  
Zhen Liu ◽  
Ling Li ◽  
...  
Keyword(s):  
Redox Cycling ◽  
Schisandrin B ◽  
Glutathione Redox

scholarly journals β-Amyloid Peptide-induced Apoptosis Regulated by a Novel Protein Containing a G Protein Activation Module

2001 ◽  
Vol 276 (22) ◽  
pp. 18748-18756 ◽  
Author(s):  
Eileen M. Kajkowski ◽  
C. Frederick Lo ◽  
Xiaoping Ning ◽  
Stephen Walker ◽  
Heidi J. Sofia ◽  
...  
Keyword(s):  
G Protein ◽  
Amyloid Peptide ◽  
Protein Activation ◽  
G Protein Activation ◽  
Β Amyloid ◽  
Β Amyloid Peptide ◽  
Induced Apoptosis ◽  
Novel Protein

Activated α2Macroglobulin Increases β-Amyloid (25–35)-Induced Toxicity in LAN5 Human Neuroblastoma Cells

1999 ◽  
Vol 155 (2) ◽  
pp. 252-259 ◽  
Author(s):  
C. Fabrizi ◽  
R. Businaro ◽  
G.M. Lauro ◽  
G. Starace ◽  
L. Fumagalli
Keyword(s):  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Β Amyloid

scholarly journals Role of NAD(P)H:quinone oxidoreductase (NQO1) in apoptosis induction by aziridinylbenzoquinones RH1 and MeDZQ.

2005 ◽  
Vol 52 (4) ◽  
pp. 937-942 ◽  
Author(s):  
Ausra Nemeikaite-Ceniene ◽  
Aldona Dringeliene ◽  
Jonas Sarlauskas ◽  
Narimantas Cenas
Keyword(s):  
Regression Analysis ◽  
Redox Cycling ◽  
Apoptosis Induction ◽  
Electron Reduction ◽  
Induced Apoptosis ◽  
Phenylene Diamine

We aimed to characterize the role of NAD(P)H:quinone oxidoreductase (NQO1) in apoptosis induction by antitumour quinones RH1 (2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone) and MeDZQ (2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone). Digitonin-permeabilized FLK cells catalyzed NADPH-dependent single- and two-electron reduction of RH1 and MeDZQ. At equitoxic concentrations, RH1 and MeDZQ induced apoptosis more efficiently than the nonalkylating duroquinone or H(2)O(2). The antioxidant N,N'-diphenyl-p-phenylene diamine, desferrioxamine, and the inhibitor of NQO1 dicumarol, protected against apoptosis induction by all compounds investigated, but to a different extent. The results of multiparameter regression analysis indicate that RH1 and MeDZQ most likely induce apoptosis via NQO1-linked formation of alkylating species but not via NQO1-linked redox cycling.

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