Potential Applications of Sarcopoterium spinosum as Medicinal Plants: Overview and Future Trends

2020 ◽  
Vol 06 ◽  
Author(s):  
Busra Ak ◽  
Eylem Atak ◽  
Merve Deniz Köse ◽  
Oguz Bayraktar
Keyword(s):  
Crude Extract ◽  
Type Ii Diabetes ◽  
Health Benefits ◽  
Type Ii ◽  
Medicinal Uses ◽  
Potential Applications ◽  
Sarcopoterium Spinosum ◽  
Common Plant ◽  
Health Applications

Abstract:: Sarcopoterium spinosum (L.) sp., is a common plant in the Mediterranean region. Over the years, S.spinosum has been used as a remedy for many diseases. One of the most known medicinal uses of the S.spinosum is the remedy for type II diabetes. Early studies were more focused on the extraction and characterization of the S.spinosum. Few pentacy-clic triterpenoids were identified in S. spinosum such as tormentic acid, ursolic acid. Due to the presence of these triterpe-noids antidiabetic, anticancer, and hepatoprotective properties of the S.spinosum have been investigated in the literature. And these studies revealed the various health benefits of the S.spinosum extract. While gathering the studies for this re-view it was seen that the effect of isolated triterpenes more preferred rather than crude extract. For this reason, studies done with both crude extract and the isolated molecules were summarized. The objective of this work is to provide a start-ing point for possible health applications for S.spinosum. This review could provide a summary of these studies on Sar-copoterium spinosum’s health benefits and its possible applications.

scholarly journals Effectiveness of using SOKARY Mobile Application on the compliance of patients with Type II diabetes: A quasi-experimental study

2021 ◽  
Vol 15 (7) ◽  
pp. 2001-2005
Author(s):  
Ehsan A. Yahia ◽  
Magda M. Bayoumi
Keyword(s):  
Mobile Health ◽  
Type Ii Diabetes ◽  
Mobile Application ◽  
Healthy Lifestyle ◽  
Mobile App ◽  
Type Ii ◽  
Level Of Activity ◽  
Quasi Experimental ◽  
Mobile Health Applications ◽  
Health Applications

Mobile health applications are an easy, friendly access method for enhancing patient’s compliance and overall health status. This study aimed to evaluate the effectiveness of using mobile health applications on patients’ compliance. A Quasi-experimental design was used with a purposeful sample of 150 subjects who have been diagnosed with type II diabetes were recruited. SOKARY android mobile application diabetes App was selected mobile health application in Arabic interface included many features as recording blood glucose level, nutrition and physical activity with medication reminders and healthy lifestyle advice notifications. The findings showed that the effectiveness of post-using the Mobile App on patient’s compliance is statistically significant 52.64+5.1, (p=0.000). Obviously, the improvement is statistically significant as recognized in lowering the level of HbA1c (p> 0.029) and BMI (p>0.006) and increasing level of activity (p>0.002) and overall patient’s compliance (p>0.004). In conclusion, the results reported significant improvement in patients’ compliance and highly recommended to utilize such mobile health applications among patients to prevent the complications of Type II diabetes. Keywords:SOKARY Mobile Application, type II diabetes, patient’s compliance, HbA1c, level of activity, BMI.

scholarly journals Characterization of pancreatic beta-cell receptors binding sulfanilamide drugs

1994 ◽  
Vol 40 (6) ◽  
pp. 47-50 ◽  
Author(s):  
V. N. Babichev ◽  
I. P. Savelyeva ◽  
M. I. Balabolkin
Keyword(s):  
Beta Cell ◽  
Binding Sites ◽  
Type Ii Diabetes ◽  
Specific Binding ◽  
Pancreatic Beta Cell ◽  
Type Ii ◽  
Cell Receptors ◽  
Number Of Binding Sites ◽  
Two Parameters

Analysis of pancreatic beta-cell receptors binding the sulfanilamide drugs widely used in therapy of type II diabetes, such as glybenclamide, glypizide, and glyclazide, showed that these drugs are characterized by excellent parameters of specific binding to these receptors. The receptors were tested for two parameters: number of binding sites and dissociation constant. Glybenclamide was the most active of the drugs we tested, the other two agents being less active. Binding of these agents was reversible. The problem of identification of the examined receptors of sulfanilamides with K+-ATP-sensitive channels, similarly active conductors of the information transported by the sulfanilamide drugs in the mechanism of insulin secretion, is discussed.

Characterization of Fibroblasts in Iatrogenic Laryngotracheal Stenosis and Type II Diabetes Mellitus

2020 ◽  
Author(s):  
Ioan Lina ◽  
Hsiu‐Wen Tsai ◽  
Dacheng Ding ◽  
Ruth Davis ◽  
Kevin M. Motz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Laryngotracheal Stenosis

scholarly journals Impact of Broccoli on Molecular Biomarkers of Liver Health (P06-001-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Alicia Arredondo Eve ◽  
Zeynep Madak-Erdogan ◽  
Elizabeth Jeffery ◽  
Michael Miller
Keyword(s):  
Gene Expression ◽  
Type Ii Diabetes ◽  
Health Benefits ◽  
Molecular Biomarkers ◽  
Type Ii ◽  
Associated Diseases ◽  
Hepatic Diseases ◽  
Freeze Dried ◽  
Liver Health ◽  
The Impact

Abstract Objectives The diet in combination with lifestyle are contributing factors to obesity-associated diseases including type II diabetes, non-alcoholic hepatic diseases, cardiovascular disease and cancer. Broccoli, a brassica vegetable, can reduce the negative effects of a detrimental diet and sedentary lifestyle that can lead to obesity and impede the development of chronic diseases. There are no established molecular biomarkers that reflect the health benefits of dietary broccoli consumption. Thus, in this study we focused on health benefits of broccoli on liver and studied the relevance of blood metabolite profile changes and gene expression patterns in liver as indicators of liver disease development and prevention. Methods Rats (n = 3) were fed an AIN93G diet with 10% cooked freeze-dried broccoli for 14 days. We examined the impact of broccoli feeding on the plasma metabolite composition by metabolomics analysis and liver gene expression changes using Q-RT-PCR after 0, 1, 2, 4, 7, 14 days of broccoli feeding. Results We identified several metabolites that changed more than 2-fold compared to the level on day 0, including metabolites that were involved in liver pathways for glutathione synthesis, amino acid metabolism and de novo fatty acid synthesis. We found that repeated broccoli consumption changes gene expression levels (CD36, CPT-1, CD68) in the liver. Conclusions Further characterizing health-promoting effects of broccoli in different in vivo obesity models will significantly expand our understanding of both liver health and the impact of dietary broccoli, having a broad impact on prevention of obesity-associated diseases, including NALFD and type II diabetes. Funding Sources Funding provided by National Institute of Food and Agriculture, U.S. Department of Agriculture, College of ACES DNS 20/20 Award, USDA/AFRI Grant.

Characterization of a new heteropolysaccharide from green guava and its application as an α-glucosidase inhibitor for the treatment of type II diabetes

2018 ◽  
Vol 9 (7) ◽  
pp. 3997-4007 ◽  
Author(s):  
Yukun Jiao ◽  
Dehong Hua ◽  
Dong Huang ◽  
Qian Zhang ◽  
Chunyan Yan
Keyword(s):  
Diabetes Mellitus ◽  
Adjuvant Treatment ◽  
Type Ii Diabetes ◽  
Functional Food ◽  
Psidium Guajava ◽  
Type Ii ◽  
Glucosidase Inhibitor ◽  
Treatment Of Diabetes ◽  
Subtropical Fruit

Psidium guajava fruit is a subtropical fruit, functional food and traditional medicine for the adjuvant treatment of diabetes mellitus in China.

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