Nephrotonic and Nephroprotective medicinal herbs in traditional Persian Medicine: Review and assessment of scientific evidence

2021 ◽  
Vol 07 ◽  
Author(s):  
Reihaneh Moeini ◽  
Zahra Memariani ◽  
Ayesheh Enayati ◽  
Narjes Gorji ◽  
Fatemeh Kolangi
Keyword(s):  
Renal Failure ◽  
Key Words ◽  
Enzyme Inhibitor ◽  
Scientific Evidence ◽  
Medicinal Herbs ◽  
Herbal Remedies ◽  
Renal Disorder ◽  
Persian Medicine ◽  
Traditional Persian Medicine ◽  
Anti Inflammatory

: The tendency to use herbal and complementary therapies has been increased dramatically in last decades. The aim of this study is reviewing nephrotonic and nephroprotective medicinal herbs in traditional Persian Medicine (TPM) historical books, and assessment of relevant scientific evidence and possible mechanisms of action. In this study, seven major references among pharmaceutical books of PM from the 11th to 19th centuries were selected and were searched with key words equivalent to “nephroprotection”. To find new studies, the scientific name of medicinal herbs which were repeated twice or more were searched using data bases including PubMed, and Google scholar with keywords of nephroprotective, renal disorder, renal failure and kidney. Also, probable effective mechanisms were explored with key words including oxidative stress, antioxidant, inflammation, anti-inflammatory and angiotensin-converting-enzyme inhibitor. 210 herbal remedies were found with kidney strengthening, nephroprotective, and atrophy prevention effects in reviewed books. The most repeated herbs were 41 Results of scientific evidence showed that the possible functional mechanisms of these plants include anti-inflammatory, anti-oxidative, blood pressure/glucose-lowering effect as well as improvement of glomerular filtration, prevention of tissue damage, and enhancing the reconstructive power of cells. The list of medicinal herbs in this study can be used as a base of future studies on production of new medicines for prevention or treatment of renal failure and for the enhancement of renal performance.

An Evidence-Based Review of Antitussive Herbs Containing Essential Oils in Traditional Persian Medicine

2020 ◽  
Vol 17 ◽  
Author(s):  
Ayda Hosseinkhani ◽  
Bijan Ziaeian ◽  
Kamran Hessami ◽  
Mohammad Mehdi Zarshenas ◽  
Ali Kashkooe ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Essential Oils ◽  
Scientific Evidence ◽  
Herbal Remedies ◽  
Future Research ◽  
Evidence Based ◽  
Online Databases ◽  
Persian Medicine ◽  
Troublesome Symptom ◽  
Traditional Persian Medicine

Background: Cough is one of the most common medical symptoms for which medical advice is sought. Although cough is a protective reflex responsible for clearing the airways from secretions and foreign bodies, it can be a troublesome symptom that causes discomfort to patients. Due to the increasing interest in herbal remedies in the both developed and developing countries, in the current study, we aimed to overview medicinal herbs containing essential oils used as antitussive agents according to the Traditional Persian Medicine [TPM] textbooks. We summarized the relevant scientific evidence on their possible pharmacological actions. Methods: To collect the evidence for treatment of cough or “seaal” [cough in ancient books] from TPM sources, five main medicinal Persian manuscripts were studied. The antitussive herbs were listed and their scientific names were identified and authenticated in accordance with botanical reference books. ScienceDirect and PubMed online databases were searched for related mechanisms of action of the reported medicinal plants. Results: The number of 49 herbs containing essential oils were recommended in TPM for the treatment of cough; 21 of them had at least one known mechanism of action for cough suppression in the scientific literature. According to this review, most of the cited medicinal plants were assessed for either nitric oxide inhibitory or antitussive/expectorant activities. Conclusion: In addition to advantageous effects of antitussive herbs noted by TPM, the present review highlighted some recent evidence-based data on these promising candidates that could be used as an outline for future research on their medicinal use.

scholarly journals Review of scientific evidence of medicinal convoy plants in traditional Persian medicine

2016 ◽  
Vol 10 (19) ◽  
pp. 33 ◽  
Author(s):  
Farid Ramezany ◽  
SeyedeNargess Sadati ◽  
MohammadReza Shams Ardekani ◽  
Nastaran Ebadi ◽  
Maryam Yakhchali ◽  
...  
Keyword(s):  
Scientific Evidence ◽  
Persian Medicine ◽  
Traditional Persian Medicine

scholarly journals An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine

2016 ◽  
Vol 22 (2) ◽  
pp. 334-343 ◽  
Author(s):  
Ayda Hosseinkhani ◽  
Maryam Falahatzadeh ◽  
Elahe Raoofi ◽  
Mohammad M. Zarshenas
Keyword(s):  
Wound Healing ◽  
Herbal Remedies ◽  
Wound Treatment ◽  
Biomedical Sciences ◽  
Persian Medicine ◽  
Natural Remedies ◽  
Traditional Persian Medicine ◽  
Developing Area ◽  
Underlying Mechanisms

Research on wound healing agents is a developing area in biomedical sciences. Traditional Persian medicine is one of holistic systems of medicine providing valuable information on natural remedies. To collect the evidences for wound-healing medicaments from traditional Persian medicine sources, 5 main pharmaceutical manuscripts in addition to related contemporary reports from Scopus, PubMed, and ScienceDirect were studied. The underlying mechanisms were also saved and discussed. Totally, 65 herbs used in traditional Persian medicine for their wound healing properties was identified. Related anti-inflammatory, antioxidant, antimicrobial, and wound-healing activities of those remedies were studied. Forty remedies had at least one of those properties and 10 of the filtered plants possessed all effects. The medicinal plants used in wound healing treatment in traditional Persian medicine could be a good topic for further in vivo and clinical research. This might lead to development of effective products for wound treatment.

Herbs with Potential Nephrotoxic Effects According to the Traditional Persian Medicine: Review and Assessment of Scientific Evidence

2018 ◽  
Vol 19 (7) ◽  
pp. 628-637 ◽  
Author(s):  
Fatemeh Kolangi ◽  
Zahra Memariani ◽  
Mahboubeh Bozorgi ◽  
Seyyed Ali Mozaffarpur ◽  
Mohaddeseh Mirzapour
Keyword(s):  
Scientific Evidence ◽  
Persian Medicine ◽  
Traditional Persian Medicine ◽  
Medicine Review

Immunomodulatory effects of medicinal plants used for vitiligo in traditional Persian medicine..

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohsen Haghir Ebrahimabadi ◽  
Seyede Nargess Sadati Lamardi ◽  
Laila Shirbeigi
Keyword(s):  
T Cells ◽  
Medicinal Plants ◽  
Scientific Evidence ◽  
New Drugs ◽  
Immunomodulatory Effects ◽  
Scientific Databases ◽  
White Spots ◽  
Persian Medicine ◽  
Traditional Persian Medicine ◽  
New Research

Background: Vitiligo is a hypopigmentation disorder that affects 1% of the world's population. Vitiligo causes white spots on the skin, mucous membranes, or white hair by destroying skin melanocytes. The pathogenesis of vitiligo is unknown, but autoimmune, autocytotoxic, and neural mechanisms are suggested. According to the autoimmune theory, in people with vitiligo, immune cells invade and damage melanocytes. T cells are more commonly present in vitiligo patients' skin and remain in the lesion site, which is composed of CD8 and CD4 T cells. Many studies have been conducted on the presence and role of cytokines such as interleukins and interferon gamma (IFN-γ) in the vitiligo process. Aim: This study aimed to introduce herbs effective against vitiligo from the perspective of Persian medicine and to investigate their possible therapeutic mechanisms with the possible effects of herbs on autoimmune mechanisms. Methods: For this purpose, keywords were used to extract data from Persian medicine textbooks, and then relevant scientific databases including Google Scholar, PubMed, Web of Science, and Scopus were examined. Results: It was found that Persian medicine scholars used 50 different medicinal plants to treat and reduce the complications of vitiligo, and recent scientific studies have the proven immune-regulating properties and reducing effect of many of them on cytokines. Conclusion: According to scientific evidence on immunomodulatory effects, new research into the effects of these plants on vitiligo can lead to the discovery of new drugs and approaches for treating this disease.

Evaluation of scientific evidence for abortifacient medicinal plants mentioned in traditional Persian medicine

2020 ◽  
Vol 5 (6) ◽  
pp. 449–463
Author(s):  
Ensiye Aafi ◽  
Malihe Tabarrai ◽  
Mehran Mirabzadeh ◽  
Mohammad Reza ◽  
Seyede Nargess
Keyword(s):  
Medicinal Plants ◽  
Scientific Evidence ◽  
Persian Medicine ◽  
Traditional Persian Medicine

An Evidence-Based Research on Botanical Sources for Oral Mucositis Treatment in Traditional Persian Medicine

2020 ◽  
Vol 17 ◽  
Author(s):  
Fatemeh Sadat Hasheminasab ◽  
Fariba Sharififar ◽  
Seyed Mehdi Hashemi ◽  
Mohammad Setayesh
Keyword(s):  
Oral Mucositis ◽  
Punica Granatum ◽  
Economic Consequences ◽  
Herbal Remedies ◽  
Current Evidence ◽  
Evidence Based ◽  
Cancer Therapies ◽  
Persian Medicine ◽  
Comprehensive Survey ◽  
Traditional Persian Medicine

Background: Cancer is one of the most prevalent diseases associated with heavy complications in treatment. Mucotoxic cancer therapies such as head and neck radiotherapy and some of the chemotherapy agents may lead to oral mucositis. In addition to its economic consequences, mucositis also affects patients' quality of life. In traditional Persian medicine (TPM) manuscripts, several medicaments have been suggested for treatment of mucositis. Objective: Considering the public welcome for herbal medicine, the current evidence-based review study is conducted to investigate the herbal remedies which have been proposed for oral mucositis in TPM. Methods: At first, a comprehensive survey was done on Qanon fi al-Teb which is the most important textbook of TPM; then the scientific name of the herbs was authenticated according to the botanical textbooks. At last, data banks including Scopus, Pubmed, Web of science and Science direct were investigated for possible relevant properties of each medicinal plant in the literature. Results: Totally 30 herbs are introduced in this study. According to the registered documents, 18 herbs are reported to have antioxidant, anti-inflammatory, antimicrobial, anti-nociceptive and wound healing properties of which the therapeutic effect of only a few herbs including Glycyrrhiza glabra, Malva sylvestris, Morus nigra, Punica granatum, and Solanum nigrum were directly evaluated against oral mucositis on the literature. Conclusion: Despite the lack of human studies on mucositis for the other discussed herbs, their related pharmacological properties can be considered for new natural drug discovery supported by medieval and traditional experiments.

scholarly journals Identification of Human Kinin-Forming Enzyme Inhibitors from Medicinal Herbs

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4126
Author(s):  
Hassan Madkhali ◽  
Amer Tarawneh ◽  
Zulfiqar Ali ◽  
Hoang V. Le ◽  
Stephen J. Cutler ◽  
...  
Keyword(s):  
Enzyme Inhibitor ◽  
Water Extract ◽  
Black Tea ◽  
Medicinal Herbs ◽  
Cell Permeability ◽  
Pulmonary Vasculature ◽  
Factor Xii ◽  
Kinin System ◽  
Anti Inflammatory

The goal of this study was to assess the pharmacological effects of black tea (Camellia sinensis var. assamica) water extract on human kinin-forming enzymes in vitro. Tea is a highly consumed beverage in the world. Factor XII (FXII, Hageman factor)-independent- and -dependent activation of prekallikrein to kallikrein leads to the liberation of bradykinin (BK) from high-molecular-weight kininogen (HK). The excessive BK production causes vascular endothelial and nonvascular smooth muscle cell permeability, leading to angioedema. The prevalence of angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema appears to be through BK. Both histamine and BK are potent inflammatory mediators. However, the treatments for histamine-mediated angioedema are unsuitable for BK-mediated angioedema. We hypothesized that long-term consumption of tea would reduce bradykinin-dependent processes within the systemic and pulmonary vasculature, independent of the anti-inflammatory actions of polyphenols. A purified fraction of the black tea water extract inhibited both kallikrein and activated FXII. The black tea water extracts inhibited factor XII-induced cell migration and inhibited the production of kallikrein on the endothelial cell line. We compared the inhibitory effects of the black tea water extract and twenty-three well-known anti-inflammatory medicinal herbs, in inhibiting both kallikrein and FXII. Surprisingly, arjunglucoside II specifically inhibited the activated factor XII (FXIIa), but not the kallikrein and the activated factor XI. Taken together, the black tea water extract exerts its anti-inflammatory effects, in part, by inhibiting kallikrein and activated FXII, which are part of the plasma kallikrein–kinin system (KKS), and by decreasing BK production. The inhibition of kallikrein and activated FXII represents a unique polyphenol-independent anti-inflammatory mechanism of action for the black tea.

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