Solid Lipid Nanoparticles for Oral Drug Delivery: A Review

2020 ◽  
Vol 10 (3) ◽  
pp. 208-224
Author(s):  
Manish Gautam ◽  
Madhu Verma ◽  
Iti Chauhan ◽  
Mohd. Yasir ◽  
Alok Pratap Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Oral Drug Delivery ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Water Soluble ◽  
Oral Drug ◽  
Pharmacokinetic Studies ◽  
Future Prospects ◽  
Solid Lipid

Background: The high molecular weight and increasing lipophilicity of drug face many problems starting from the drug development to formulation and conduction of pharmacological, toxicological and pharmacokinetic studies to its biological application. To overcome this problem, nano-sized formulations are in trend recently. The use of Solid lipid nanoparticles (SLNs) offers new insight into the formulation of the poor soluble and low bioavailable drug. Objective: The study aimed to investigate the literature concerning the development of SLNs for oral drug delivery of poorly soluble drugs, with a view survey the various methods of manufacturing and evaluation of formulation of SLNs and future prospects of SLNs and application of SLNs in oral delivery systems. Conclusion: Oral drug delivery is looking ahead progressively into newer directions due to the realization of various poor performance limiting factors such as reduced drug solubility or absorption, rapid metabolism, high actuation in plasma level of drug and variability caused due to food effect. These play a vital role in disappointing in vivo results, which leads in the failure of the conventional delivery system. Since the last decade, oral drug delivery has taken a new dimension with the increasing application of SLNs as a carrier for the delivery of poorly water-soluble or lipophilic drugs. The site-specific and sustained release effect of the drug is better achieved by using SLNs. This review highlights the various pros and cons, manufacturing techniques, characterization, and future prospects of SLNs in oral drug delivery systems.

scholarly journals A concise review on preparation methods used for the development of solid lipid nanoparticles

2021 ◽  
Vol 11 (1-s) ◽  
pp. 162-169
Author(s):  
Vasu Deva Reddy Matta
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Oral Drug Delivery ◽  
Lipid Nanoparticles ◽  
Water Soluble ◽  
Oral Drug ◽  
Preparation Methods ◽  
Hydrophilic Drugs ◽  
Solid Lipid

Solid lipid nanoparticles (SLNs) are in submicron size range nanoparticles and are made of biocompatible and biodegradable materials (mainly composed of lipids and surfactants) capable of incorporating both lipophilic and hydrophilic drugs. SLNs are also considered as substitute to other colloidal drug systems, also used as controlled systems and targeted delivery. SLNs can be considered as an alternative for oral drug delivery vehicle to improve the oral bioavailability of drugs, associated reduction of drug toxicity and stability of drug in both GIT and plasma. There are different techniques used for the preparation of SLNs. Generally, the preparation of SLNs and any other nanoparticle system necessitates a dispersed system as precursor; otherwise particles are produced through the use of a particular instrumentation. This review provides the summary on the techniques or methods used for the development of SLNs of poorly water soluble drugs for improved drug delivery. Keywords: Solid lipid nanoparticles, controlled delivery, precursor, techniques.

Solid lipid nanoparticles for oral drug delivery

2020 ◽  
Author(s):  
S. Khaleel Basha ◽  
R. Dhandayuthabani ◽  
M. Syed Muzammil ◽  
V. Sugantha Kumari
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Oral Drug Delivery ◽  
Lipid Nanoparticles ◽  
Oral Drug ◽  
Solid Lipid

Challenges in oral drug delivery and applications of lipid nanoparticles as potent oral drug carriers for managing cardiovascular risk factors

2020 ◽  
Vol 21 ◽  
Author(s):  
Neslihan Üstündağ Okur ◽  
Panoraia I. Siafaka ◽  
Evren Homan Gökçe
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Risk ◽  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Oral Drug Delivery ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Nanostructured Lipid Carriers ◽  
Oral Drug ◽  
Solid Lipid

Background: The oral application of drugs is the most popular route through which the systemic effect can be achieved. Nevertheless, oral administration is limited by difficulties related to physicochemical properties of the drug molecule, including low aqueous solubility, instability, low permeability, and rapid metabolism, all of which result in low and irregular oral bioavailability. Objective: The enhancement of oral bioavailability of drug molecules with such properties could lead to extreme complications in drug preparations. Oral lipid based nanoparticles seems to possess extensive advantages due to their ability to increase the solubility, simplifying intestinal absorption and decrease or eradicate the effect of food on the absorption of low soluble, lipophilic drugs and therefore improving the oral bioavailability. Method: The present review provides a summary of the general theory of lipid based nanoparticles, their preparation methods as well as their oral applications. Moreover, the oral drug delivery challenges are discussed. Results: According to this review, the most frequent types of lipid-based nanoparticle, the solid lipid nanoparticles and nanostructured lipid carriers are potent oral carriers due to their ability to penetrate the oral drug adsorption barriers. Moreover, such lipid nanoparticles can be beneficial drug carriers against cardiovascular risk disorders as diabetes, hypertension etc. Conclusion: In this review, the most current and promising studies involving Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as oral drug carriers are reported aiming to assist researchers who focus their research on lipid based nanoparticles.

A Comprehensive Review on Solid Lipid Nanoparticles as Delivery Vehicle for Enhanced Pharmacokinetic and Pharmacodynamic Activity of Poorly Soluble Drugs

2019 ◽  
Vol 12 (2) ◽  
pp. 4421-4440 ◽  
Author(s):  
Narendar Dudhipala
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Current Status ◽  
Oral Drug ◽  
Poorly Soluble Drugs ◽  
Solid Lipid ◽  
Poorly Soluble

This article describes the current state and future perspectives of solid lipid nanoparticles for achieving high delivery of drugs with greater therapeutic outcomes.  The oral route is the most preferred route of administration for majority of drugs. Problems such as poor solubility or chemical stability in the environment of the gastrointestinal tract, poor permeability through the biological membranes or sensitivity to metabolism are well known to result in the rejection of potential drug candidates as oral delivery products. Hence, lipid-based drug delivery systems have been proposed as a means of bypassing the resistant chemical or physical barriers associated with poorly absorbed drugs. Solid lipid nanoparticles (SLNs) can be an attractive one option for oral drug delivery vehicles as they hold tremendous potential to improve the oral bioavailability of drugs, concomitant reduction of drug toxicity and stability of drug in both GIT and plasma. SLNs are in submicron size range and are made of biocompatible and biodegradable materials capable of incorporating both lipophilic and hydrophilic drugs. SLNs are considered as substitute to other colloidal drug systems and are being used as controlled and targeted delivery systems. The SNL technology has greatly revolutionized the delivery systems for poorly soluble drugs. This article describes the methodologies used for preparation and characterization of SNLs.  It outlined the development of stable solid lipid nanoparticles by different techniques. Further, it describes the current status of pharmacokinetic and pharmaco-dynamic studies reported on SLN systems. Finally, it provides a brief outlook on current marketed preparation and the future scope of SLN technology.

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