Studying of the CLL After Treatment Using Fractal Parameter of Neoplastic Lymphocytes Detection (λnld)

2021 ◽  
pp. 24-34
Author(s):  
Mohammad Reza Rezaei ◽  
Zahra Rostami
Keyword(s):  
Fractal Parameter ◽  
Neoplastic Lymphocytes

Cutaneous Lymphosarcoma of Helper/Inducer T-Cell Origin in a Calf

1987 ◽  
Vol 24 (6) ◽  
pp. 504-508 ◽  
Author(s):  
R. D. Zwahlen ◽  
A. Tontis ◽  
A. Schneider
Keyword(s):  
T Cell ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Mycosis Fungoides ◽  
Lymphoproliferative Disease ◽  
T Helper ◽  
Regional Lymph Nodes ◽  
Skin Nodules ◽  
Neoplastic Lymphocytes ◽  
Suggested Classification

A calf with a lymphoproliferative disease resembling human mycosis fungoides, had multiple, ulcerated skin nodules with enlarged regional lymph nodes. Tumor cells were 10–15 μm in diameter and had round to oval nuclei without indentations. Mitoses were regularly present. Pautrier's microabscesses were in the epidermis, and T-cell areas of regional lymph nodes were infiltrated by neoplastic cells. Demonstration of the T-helper/inducer origin of neoplastic lymphocytes suggested classification in analogy with human mycosis fungoides.

Which Fractal Parameter Contributes Most to Adhesion?

2010 ◽  
Vol 24 (15-16) ◽  
pp. 2383-2396 ◽  
Author(s):  
D.-L. Liu ◽  
J. Martin ◽  
N. A. Burnham
Keyword(s):  
Fractal Parameter

Emperipolesis-like Invasion of Neoplastic Lymphocytes into Hepatocytes in Feline T-cell Lymphoma

2011 ◽  
Vol 144 (4) ◽  
pp. 312-316 ◽  
Author(s):  
M. Suzuki ◽  
Y. Kanae ◽  
Y. Kagawa ◽  
N. Ano ◽  
K. Nomura ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Neoplastic Lymphocytes

Malignant lymphoma with middle ear involvement in a Sprague-Dawley rat

2018 ◽  
Vol 52 (4) ◽  
pp. 418-423
Author(s):  
Jean-Francois Lafond ◽  
Annick Landry
Keyword(s):  
Malignant Lymphoma ◽  
Temporal Bone ◽  
Middle Ear ◽  
Chorda Tympani ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Sprague Dawley Rats ◽  
Microscopic Evaluation ◽  
Neoplastic Lymphocytes ◽  
Tensor Tympani Muscle

Sprague-Dawley rats are amongst the most widely used animals in biomedical research and malignant lymphoma has long been known to be a frequent neoplasm in these animals. A 9-month-old male control Sprague-Dawley rat from a toxicity study showed gelatinous material in the cranial cavity and dark, thickened cerebral meninges at necropsy. At microscopic evaluation of the temporal bone, neoplastic lymphocytes were seen invading several structures of the middle ear. The neoplastic cells appeared to extend from the marrow of the temporal bone, covered the dorsal part of the tympanic cavity wall, and surrounded and infiltrated the base of the tensor tympani muscle as well as the chorda tympani branch of the facial nerve. The lymphoma was generalized; neoplastic lymphocytes were also noted in numerous other tissues. Literature regarding neoplasms of the middle and inner ear in animals is scarce and, to our knowledge, this is the first report of a lymphoma involving the middle ear of a rat.

scholarly journals Morphologic and Immunohistochemical Characterization of Spontaneous Lymphoma/Leukemia in NSG Mice

2019 ◽  
Vol 57 (1) ◽  
pp. 160-171 ◽  
Author(s):  
Heather Tillman ◽  
Laura J. Janke ◽  
Amy Funk ◽  
Peter Vogel ◽  
Jerold E. Rehg
Keyword(s):  
T Cell ◽  
Core Protein ◽  
Laboratory Mouse ◽  
Interleukin 2 ◽  
Low Frequency ◽  
Nsg Mice ◽  
Severe Immunodeficiency ◽  
Neoplastic Lymphocytes ◽  
Strong Immunoreactivity

The NOD.Cg- Prkdcscid Il2rgtm1Wjl/SzJ strain (NOD scid gamma, NSG) is a severely immunodeficient inbred laboratory mouse used for preclinical studies because it is amenable to engraftment with human cells. Combining scid and Il2rgnull mutations results in severe immunodeficiency by impairing the maturation, survival, and functionality of interleukin 2–dependent immune cells, including T, B, and natural killer lymphocytes. While NSG mice are reportedly resistant to developing spontaneous lymphomas/leukemias, there are reports of hematopoietic cancers developing. In this study, we characterized the immunophenotype of spontaneous lymphoma/leukemia in 12 NSG mice (20 to 38 weeks old). The mice had a combination of grossly enlarged thymus, spleen, or lymph nodes and variable histologic involvement of the bone marrow and other tissues. All 12 lymphomas were diffusely CD3, TDT, and CD4 positive, and 11 of 12 were also positive for CD8, which together was consistent with precursor T-cell lymphoblastic lymphoma/leukemia (pre-T-LBL). A subset of NSG tissues from all mice and neoplastic lymphocytes from 8 of 12 cases had strong immunoreactivity for retroviral p30 core protein, suggesting an association with a viral infection. These data highlight that NSG mice may develop T-cell lymphoma at low frequency, necessitating the recognition of this spontaneously arising disease when interpreting studies.

Oncogenes in normal and neoplastic lymphocytes

1987 ◽  
Vol 8 (11) ◽  
pp. 171-174 ◽  
Author(s):  
Peter C. Nowell ◽  
John C. Reed ◽  
Carlo M. Croce
Keyword(s):  
Neoplastic Lymphocytes

Acute bilateral trigeminal neuropathy associated with nervous system lymphosarcoma in a dog

2000 ◽  
Vol 36 (1) ◽  
pp. 57-61 ◽  
Author(s):  
AM Pfaff ◽  
PA March ◽  
C Fishman
Keyword(s):  
Nervous System ◽  
Histopathological Examination ◽  
Clinical Signs ◽  
Neoplastic Cell ◽  
Brain Parenchyma ◽  
Spinal Root ◽  
Trigeminal Neuropathy ◽  
Neoplastic Lymphocytes ◽  
Multicentric Lymphoma ◽  
Masseter Muscles

A nine-year-old dog presented with clinical signs consistent with bilateral trigeminal neuropathy. Multicentric lymphoma was diagnosed, and neoplastic lymphocytes were identified in the cerebrospinal fluid. Electromyography revealed spontaneous activity in temporal and masseter muscles. Histopathological examination demonstrated neoplastic cell invasion of temporal and masseter myofibers and of multiple peripheral nerves, including the trigeminal nerve. Central nervous system pathology consisted primarily of spinal root and leptomeningeal lymphoid cell infiltration with relative sparing of spinal cord and brain parenchyma.

CRYPTANALYSIS ON SECURE FRACTAL IMAGE CODING BASED ON FRACTAL PARAMETER ENCRYPTION

Fractals ◽  
2012 ◽  
Vol 20 (01) ◽  
pp. 41-51 ◽  
Author(s):  
CHING-HUNG YUEN ◽  
KWOK-WO WONG
Keyword(s):  
Image Coding ◽  
Standard Test ◽  
Scaling Factor ◽  
Depth Information ◽  
Selective Encryption ◽  
Fractal Parameter ◽  
Fractal Image ◽  
Fractal Image Coding ◽  
Plain Image ◽  
Domain Block

The vulnerabilities of the selective encryption scheme for fractal image coding proposed by Lian et al.1 are identified. By comparing multiple cipher-images of the same plain-image encrypted with different keys, the positions of unencrypted parameters in each encoded block are located. This allows the adversary to recover the encrypted depth of the quadtree by observing the length of each matched domain block. With this depth information and the unencrypted parameters, the adversary is able to reconstruct an intelligent image. Experimental results show that some standard test images can be successfully decoded and recognized by replacing the encrypted contrast scaling factor and brightness offset with specific values. Some remedial approaches are suggested to enhance the security of the scheme.

Fractal Parameter Space of Lorenz-like Attractors: A Hierarchical Approach

2014 ◽  
pp. 87-104
Author(s):  
Tingli Xing ◽  
Jeremy Wojcik ◽  
Michael A. Zaks ◽  
Andrey Shilnikov
Keyword(s):  
Parameter Space ◽  
Hierarchical Approach ◽  
Fractal Parameter

Erythropoietin for the treatment of anemia of malignancy associated with neoplastic bone marrow infiltration.

1990 ◽  
Vol 8 (6) ◽  
pp. 956-962 ◽  
Author(s):  
W Oster ◽  
F Herrmann ◽  
H Gamm ◽  
G Zeile ◽  
A Lindemann ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bolus Injection ◽  
Bone Marrow Involvement ◽  
Serum Levels ◽  
Underlying Disease ◽  
Bone Marrow Infiltration ◽  
Low Grade ◽  
History Of ◽  
Neoplastic Lymphocytes ◽  
Rbc Count

This clinical trial was performed to study the effects of intravenously (IV) administered recombinant human (rh) erythropoietin (EPO) at escalating doses (150, 300, and 450 U/kg, administered as an IV bolus injection, twice weekly, for 6, 4, and 4 weeks, respectively) in five patients with low-grade non-Hodgkin's lymphoma (Ig NHL) and bone marrow involvement and one patient with multiple myeloma (MM). All patients were anemic due to underlying disease. None of the patients had a history of bleeding, hemolysis, renal insufficiency, or other disorders causing anemia in addition to bone marrow infiltrating malignancy. Endogenous EPO serum levels were significantly increased in all patients (74 to 202 mU/mL). Five patients (one MM, four small-cell lymphocytic [SCLC] NHL) showed a dramatic increase of hemoglobin (Hb), hematocrit (Hk) and RBC count becoming obvious on the second EPO dose level. Initial ferritin serum values, which were high mostly due to polytransfusion, were significantly reduced in responding patients. Erythropoiesis of one patient with extensive follicular mixed (fm) NHL did not respond to EPO treatment. Platelet (PLT) count increase (greater than 75% above starting levels) during and following EPO therapy was observed in one patient with MM. Adverse events due to EPO therapy have not been recorded. These findings point out a previously unrecognized capacity of EPO given at pharmacologic doses to stimulate erythropoiesis in patients with anemia due to bone marrow infiltration by neoplastic lymphocytes in spite of enhanced endogenous EPO expression.

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