scholarly journals The Efficacy of Cognitive-Communicative Intervention in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 17 (2) ◽  
pp. 147-167
Author(s):  
Mi Sook Lee
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Meta Analysis ◽  
Target Population ◽  
Review Literature ◽  
Intervention Programs ◽  
Effect Sizes ◽  
Communication Intervention ◽  
Evidence Based ◽  
Word Fluency

Mild cognitive impairment (MCI) is the sign of dementia, and is critical for prediction and preventing its progressions. This study aimed to review literature on cognitive communication intervention of MCI patients systematically, and propose the evidence-based data, including their effect sizes using a meta-analysis method. Thirty-eight researches published since 2012, meeting the inclusion and exclusion criteria, were entered into this analysis. They were analyzed in qualitative aspects, and their effect sizes were calculated in a level of mean and each domain. Outcome measures included the domains of 10 cognitions and 4 communications. The main findings were as follows. Firstly, the general target population for studies was MCI over the age of 50, and intervention programs were designed diversely in a session or mode. Secondly, several domains, including attention, memory, and executive function held a large portion of the intervention programs. Thirdly, the average effect size of interventions was large. Lastly, processing speed and word fluency were very effective and significant among domains in the results of treatment. Current study provides evidence-based information to support cognitive-communication intervention for individuals with MCI. These results also can contribute to diversify intervention approaches and verify their efficacies. Given this, it is possible to facilitate the cognitive-communication intervention for MCI in clinical settings.

scholarly journals Cognitive-Communicative Predictors of Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 16 (4) ◽  
pp. 276-294
Author(s):  
Mi Sook Lee
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Meta Analysis ◽  
Target Population ◽  
Moderate Level ◽  
Effect Sizes ◽  
Evidence Based ◽  
Word Fluency ◽  
Predictive Values ◽  
Level Effect

Mild cognitive impairment (MCI) is the preclinical stage and sign of dementia. It is also important for guidance in the prevention and intervention of neurological disease. The purpose of this study was to review literatures on cognitive/communicative and other predictors of MCI patients systematically, and to propose the evidence-based data including effect sizes of them using a meta-analysis method. Fifty-seven researches published since 2010, meeting the inclusion and exclusion criteria, were entered into the analysis. They were analyzed in a methodological and content level, and the effect sizes were calculated by 3 predictors. Predictive values were pooled from cognitive (10 domains), communicative (9 domains), and other (3 domains). The main findings were as follows. Firstly, the general target population for studies was older adults over the age of 55, and most studies included at least 2 types of predictors. Secondly, average effect sizes of 3 predictors in MCI were all significant. Thirdly, cognitive predictors like memory and general cognition had significant and high-level effect sizes. Fourthly, communicative predictors including comprehension and word fluency had moderate-level effect sizes significantly. Lastly, all demographic and neuropsychological (age, education, depression) predictors had significant and moderate-level effect sizes. Our results provide the evidence-based information to predict MCI. Especially, specific cognitive and communicative predictors may contribute to increase the diagnostic and prognostic accuracy in MCI. This study is also expected to present clinically available data and increase the effect in intervention for MCI.

scholarly journals A-012 Meta-Analysis of Neuropsychological Intra-Individual Variability in Dementia and Mild-Cognitive Impairment

2020 ◽  
Vol 35 (6) ◽  
pp. 802-802
Author(s):  
Aita S ◽  
Demming C ◽  
Knapp D ◽  
Hill B
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Effect Size ◽  
Meta Analysis ◽  
Individual Variability ◽  
Effect Sizes ◽  
Clinical Samples ◽  
Original Research ◽  
Study Heterogeneity ◽  
Main Index

Abstract Objective Neuropsychological intra-individual variability (IIV) refers to within-person cognitive fluctuation. It is often measured within-task (i.e., consistency) and across-tasks (i.e., dispersion). This investigation meta-analyzed studies comparing cognitive IIV of dementia and mild cognitive impairment (MCI) participants to normal controls. Method Eight databases within the EBSCO network as well as ProQuest Dissertations & Theses were searched for original research comparing cognitive IIV between clinical and control samples. Studies were coded using a complex multi-comparison, outcome, and subgroup schema. All data were analyzed under random-effects modeling using Comprehensive Meta-Analysis. Main index of effect size was Hege’s g. The Q and I2 statistics were used to formally assess heterogeneity. Continuous and categorical moderator variables were tested using meta-regression and subgroup analysis, respectively. Results This study was a part of a broader meta-analysis looking at IIV across all clinical samples. The initial search strategy yielded 2,962 results, which were reduced to 87 studies for final inclusion. From which, the current meta-analysis included 28 consistency studies (dementia: k = 13, 88 effect sizes; MCI: k = 15, 110 effect sizes) and 16 dispersion studies (dementia: k = 10, 36 effect sizes; MCI: k = 6, 14 effect sizes). Meta-analysis revealed a greater combined effect size for dementia samples (consistency: g = 0.92; dispersion: g = 1.11) than MCI (consistency: g = 0.33; dispersion: g = 0.56). Significant between-study heterogeneity was noted across analyses. Age and education were the only notable moderators. Conclusions All clinical subgroups demonstrated significantly elevated IIV compared to controls. The extent of IIV was proportionate to neurologic burden. Dispersion-based IIV may be a more sensitive marker of neural integrity than consistency.

scholarly journals The Prevalence of Mild Cognitive Impairment among Chinese People: A Meta-Analysis

2021 ◽  
Vol 55 (2) ◽  
pp. 79-91
Author(s):  
Yan Deng ◽  
Siqi Zhao ◽  
Guangwen Cheng ◽  
Jiajia Yang ◽  
Benchao Li ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diagnostic Criteria ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Internal Validity ◽  
Screening Tools ◽  
Chinese Elderly ◽  
Pooled Prevalence

<b><i>Background:</i></b> Mild cognitive impairment (MCI) induced the majority number of dementia patients. The prevalence of MCI in China varied across studies with different screening tools and diagnostic criteria. <b><i>Objective:</i></b> A systematic review and meta-analysis was conducted to estimate the pooled MCI prevalence among the population aged 55 years and older in China. <b><i>Methods:</i></b> PubMed, EMBASE, CNKI, Wanfang, CQVIP, and CBMdisc were searched for studies on prevalence of MCI among Chinese elderly between January 1, 1980, and February 10, 2020. The quality assessment was conducted via external validity, internal validity, and informativity, the pooled prevalence was calculated through the random-effect model, and the homogeneity was evaluated by Cochran’s <i>Q</i> test and <i>I</i><sup>2</sup>. <b><i>Results:</i></b> Fifty-three studies with 123,766 subjects were included. The pooled prevalence of MCI among Chinese elderly was 15.4% (95% CI: 13.5–17.4%). Subgroup analyses indicated that the prevalence calculated with different screening tools was 20.2% (95% CI: 15.1–25.9%) for Montreal Cognitive Assessment (MoCA) and 13.0% (95% CI: 10.7–15.5%) for Mini-Mental State Examination (MMSE). According to different diagnostic criteria, the prevalence was 14.8% (95% CI: 12.2–17.6%) for Petersen criteria, 15.0% (95% CI: 12.7–17.5%) for DSM-IV, and 21.2% (95% CI: 17.5–25.2%) for Chinese Expert Consensus on Cognitive Impairment (CECCI). Besides, women, older adults, illiterate people, rural residents, and those who lived with unhealthy lifestyles and morbidity showed higher prevalence. <b><i>Conclusions:</i></b> The prevalence of MCI in China was 15.4%, which varied by demographics, lifestyles, morbidity, screening tools, and diagnostic criteria. In further studies, screening tools and diagnosis criteria should be considered when estimating MCI prevalence.

scholarly journals Repetition Priming in Individuals with Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia: a Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Liselotte De Wit ◽  
Vitoria Piai ◽  
Pilar Thangwaritorn ◽  
Brynn Johnson ◽  
Deirdre O’Shea ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Repetition Priming ◽  
Meta Analysis ◽  
Healthy Older Adults ◽  
Amnestic Mci ◽  
Standard Mean Difference ◽  
Priming Paradigm

AbstractThe literature on repetition priming in Alzheimer’s disease (AD) is inconsistent, with some findings supporting spared priming while others do not. Several factors may explain these inconsistencies, including AD severity (e.g., dementia vs. Mild Cognitive Impairment; MCI) and priming paradigm-related characteristics. This systematic review and meta-analysis provides a quantitative summary of repetition priming in AD. We examined the between-group standard mean difference comparing repetition priming in AD dementia or amnestic MCI (aMCI; presumably due to AD) to controls. Thirty-two studies were selected, including 590 individuals with AD dementia, 267 individuals with amnestic MCI, and 703 controls. Our results indicated that both individuals with aMCI and AD dementia perform worse on repetition priming tasks than cognitively older adults. Paradigm-related moderators suggested that the effect size between studies comparing the combined aMCI or AD dementia group to cognitively healthy older adults was the highest for paradigms that required participants to produce, rather than identify, primes during the test phase. Our results further suggested that priming in AD is impaired for both conceptual and perceptual priming tasks. Lastly, while our results suggested that priming in AD is impaired for priming tasks that require deep processing, we were unable to draw firm conclusions about whether priming is less impaired in aMCI or AD dementia for paradigms that require shallow processing.

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