scholarly journals CONNECTION OF VITAMIN D WITH MARKERS OF REPRODUCTIVE FUNCTION IN PATIENTS WITH WITH POLYCYSTIC OVARY SYNDROME

2021 ◽  
Vol 78 (4) ◽  
pp. 7-13
Author(s):  
Tetiana Arkhypkina ◽  
Volodymyr Bondarenko ◽  
Lidiia Lyubimovа
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Vitamin D Deficiency ◽  
Polycystic Ovary ◽  
Negative Relationship ◽  
Reproductive Function ◽  
Sex Hormone Binding Globulin ◽  
Ovary Syndrome ◽  
Gonadotropin Secretion ◽  
Antral Follicles

Objective. To investigate the relationship between vitamin D and markers of reproductive function in women with polycystic ovary syndrome (PCOS) and to assess of their changes with cholecalciferol.Materials and methods. Thirty patients with PCOS and 20 healthy women with vitamin D deficiency, who similar for the age and body weight, were examined. Vitamin D, antimullerian hormone (AMH), number of antral follicles, follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), estradiol (E2), sex hormone-binding globulin (SHBG), ovarian ultrasound parameters before and after 12 weeks of cholecalciferol therapy at a dose of 4000 IU daily were determined.Results. Before treatment, was not found association between vitamin D and AMG and the number of antral follicles in both groups. In patients with PCOS was found a negative relationship between vitamin D and T (r = – 0.579; P < 0.001), free androgen index (r = – 503; Р < 0.01), LH/FSH (r = – 0.591, P < 0.001), T/E2 (r = – 0.603; P < 0.001) and positive correlation with SHBG (r = 0.611; P < 0.001), which indicates the role of vitamin D deficiency in the formation of hyperandrogenemia. The therapy of cholecalciferol did not affect the level of AMН, at the same time, was accompanied by changes in gonadotropin secretion and their ratio, reduction of hyperandrogenemia and positive dynamics of folliculogenesis.Conclusion. We believe that the appointment of vitamin D in patients with PCOS is promising, as it has a positive effect on indicators that reflect the state of reproductive function.

scholarly journals Vitamin D deficiency in women with polycystic ovary syndrome

2014 ◽  
Vol 41 (2) ◽  
pp. 80 ◽  
Author(s):  
Jin Ju Kim ◽  
Young Min Choi ◽  
Soo Jin Chae ◽  
Kyu Ri Hwang ◽  
Sang Ho Yoon ◽  
...  
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Vitamin D Deficiency ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals P154 Effect of Vitamin D Deficiency on Insulin Induced Vasodilatation and Receptor Expression in Rat Model of Polycystic Ovary Syndrome

2020 ◽  
Vol 25 (Supplement 1) ◽  
pp. S192
Author(s):  
Bálint Bányai ◽  
Benko Rita ◽  
Tarszabó Róbert ◽  
Lajtai Krisztina ◽  
Horváth Eszter Mária ◽  
...  
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Vitamin D Deficiency ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Receptor Expression ◽  
Ovary Syndrome

scholarly journals The relationship between Vitamin D deficiency and polycystic ovary syndrome

2020 ◽  
Vol 20 (4) ◽  
pp. 1880-6
Author(s):  
Feyzi Gokosmanoglu ◽  
Attila Onmez ◽  
Hasan Ergenç
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Vitamin D Deficiency ◽  
Polycystic Ovary ◽  
Serum Testosterone ◽  
Dehydroepiandrosterone Sulfate ◽  
Thyroid Function Tests ◽  
Ovary Syndrome ◽  
Group 2 ◽  
Group 1

Background: Vitamin D deficiency is frequently seen in patients with polycystic ovary syndrome (PCOS) and has been shown to exhibit multiple effects on the disease process. The purpose of this study was to investigate the role of vitamin D deficiency in complex PCOS pathophysiological pathways. Methods: Two hundred sixty-seven patients with PCOS were divided into two groups Group 1 with 25(OH)D3 deficiency, and Group 2 with normal 25(OH)D3. Biochemical and hormonal parameters (androgen hormones, gonadotropins, and thyroid function tests) were compared between the two groups. Results: Eighty-six percent of the patients (n=231) were in Group 1 and 14% (n=36) in Group 2. Statistically signifi- cantly higher concentrations of serum testosterone, dehydroepiandrosterone-sulfate and LH were determined in Group 1 (p<0.05). 25(OH)D3 concentrations were negatively correlated with body mass index (r=−0.459), serum testosterone (r =−0.374) and dehydroepiandrosterone-sulfate levels (r=−0.418); (all; p< 0.05). Conclusion: The study findings show that low 25(OH)D3 levels are associated with high androgen levels in women with PCOS. Vitamin D deficiency should be considered as an additional risk factor in the development of PCOS. We think that providing vitamin D supplementation for women from identified deficiency areas can reduce the risk of PCOS development. Keywords: Polycystic ovarian syndrome; vitamin D deficiency; androgen hormones; testosterone.

Effects of exercise and nutritional counseling in women with polycystic ovary syndrome

2006 ◽  
Vol 31 (4) ◽  
pp. 384-391 ◽  
Author(s):  
Brenda Bruner ◽  
Karen Chad ◽  
Donna Chizen
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovarian Follicle ◽  
Resting Metabolic Rate ◽  
Reproductive Function ◽  
Sex Hormone Binding Globulin ◽  
Hormonal Changes ◽  
Nutritional Counseling ◽  
Post Intervention ◽  
Ovary Syndrome

This pilot study assessed the effects of exercise and nutritional counseling on hormonal, menstrual, and reproductive function in women with polycystic ovary syndrome (PCOS). Twelve females with a clinical, biochemical, and ultrasonographic diagnosis of PCOS were randomly assigned to endurance and resistance exercise plus nutritional counseling (EN) or nutritional counseling only (N) for a period of 12 weeks. Anthropometry, resting metabolic rate (RMR), selected hormones, and ovarian follicle population were measured pre and post-intervention. Following the 12 week intervention, greater decreases in sum of 2 skinfolds (p = 0.002) and a greater increase in estimated VO2 max (p = 0.017) occurred in the exercise group. Significant decreases in waist girth (p = 0.001) and insulin levels (p = 0.03) occurred in both groups. Hormonal changes were not statistically significant; however, a trend towards an improved hormonal profile, specifically sex-hormone binding globulin (EN, 39% increase; N, 8% increase) and lutenizing hormone : follicle-stimulating hormone (LH:FSH) (EN, 9% decrease; N, 27% decrease) occurred in the absence of weight loss. These findings suggest exercise and nutritional counseling may benefit the metabolic and reproductive abnormalities associated with PCOS.

scholarly journals Study of serum calcium and vitamin D levels with hormonal profile along with biochemical profile in women with polycystic ovary syndrome

2017 ◽  
Vol 6 (9) ◽  
pp. 4075
Author(s):  
Ilangovan Subashree ◽  
Umakant Ramchandra Valvekar ◽  
Geetha Prasad
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Vitamin D Deficiency ◽  
Serum Calcium ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Control Female ◽  
Hormonal Profile ◽  
Vitamin D Levels

Background: The polycystic ovary syndrome (PCOS) is one of the commonest human endocrinopathies and is increasingly recognized as a variant of the metabolic syndrome in women with the characteristic features of insulin resistance, central obesity, impaired glucose metabolism, dyslipidemia, and hypertension.Methods: This study is mainly focused on study of parameters like gonadotropin hormonal profile, serum vitamin D and calcium levels in polycystic ovary disease (PCOD). The study comprised 45 clinically proven polycystic ovary disease patients in the age range of 19-34 years. The biochemical estimations carried out in the study were – Fasting Blood sugar, LH, FSH, prolactin, 25- OH vitamin D and calcium along with anthropometric data. The values obtained were compared with age matched equal number of healthy control female subjects from the same population.Results: The serum concentration of calcium and vitamin D levels are decreased significantly (P <0.001) when compared to controls. Insulin resistance is predominantly seen in PCOS subjects. The study outlines the importance of insulin resistance, dyslipidemia, decreased serum calcium and vitamin D levels in PCOS subjects may be a cause for the progression of polycystic ovary syndrome.Conclusions: In the present study vitamin D deficiency is highly prevalent in PCOS women from this area compared to control women. We also relations of vitamin D status with insulin sensitivity, HDL-C, and C-reactive protein in PCOS patients, which support the increasing evidence that vitamin D deficiency is associated with multiple metabolic risk factors in PCOS women. A high prevalence of vitamin D deficiency and low calcium levels were observed in PCOS women from our population when compared to controls. Insulin resistance was predominantly seen in PCOS subjects when compared with controls, indicating the association of vitamin D levels with insulin resistance.

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