The effect of vitamin D3 on improving lipid profile, fasting glucose and insulin resistance in polycystic ovary syndrome women with vitamin D deficiency

Objective: To evaluate the effect of vitamin D supplementation (alone or with co-supplementation) on insulin resistance in patients with polycystic ovary syndrome (PCOS). Methods: We performed a literature search of databases (Medline, Scopus, Web of Knowledge, Cochrane Library) and identified all reports of randomized controlled trials (RCTs) published prior to April 2018. We compared the effects of supplementation with vitamin D alone (dose from 1000 IU/d to 60,000 IU/week) or with co-supplements to the administration of placebos in women diagnosed with PCOS. The systematic review and meta-analysis protocol was registered in the International Prospective Register of Systematic Reviews (Prospero) as number CRD42018090572. Main results: Eleven of 345 identified studies were included in the analysis; these involved 601women diagnosed with PCOS. Vitamin D as a co-supplement was found to significantly decrease fasting glucose concentrations and the HOMA-IR value. HOMA-IR also declined significantly when vitamin D was supplemented with a dose lower than 4000 IU/d. Conclusions: Evidence from RCTs suggests that the supplementation of PCOS patients with continuous low doses of vitamin D (<4000 IU/d) or supplementation with vitamin D as a co-supplement may improve insulin sensitivity in terms of the fasting glucose concentration (supplementation with vitamin D in combination with other micronutrients) and HOMA-IR (supplementation with vitamin D in continuous low daily doses or as co-supplement).

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Vitamin D deficiency, metabolic syndrome and insulin resistance among Saudi women with polycystic ovary syndrome

Fertility and Sterility ◽

10.1016/j.fertnstert.2010.07.750 ◽

2010 ◽

Vol 94 (4) ◽

pp. S193

Author(s):

A.A. Rouzi ◽

M.S. Ardawi

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Vitamin D Deficiency ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Saudi Women

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Study of serum calcium and vitamin D levels with hormonal profile along with biochemical profile in women with polycystic ovary syndrome

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20174065 ◽

2017 ◽

Vol 6 (9) ◽

pp. 4075

Author(s):

Ilangovan Subashree ◽

Umakant Ramchandra Valvekar ◽

Geetha Prasad

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Vitamin D Deficiency ◽

Serum Calcium ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Control Female ◽

Hormonal Profile ◽

Vitamin D Levels

Background: The polycystic ovary syndrome (PCOS) is one of the commonest human endocrinopathies and is increasingly recognized as a variant of the metabolic syndrome in women with the characteristic features of insulin resistance, central obesity, impaired glucose metabolism, dyslipidemia, and hypertension.Methods: This study is mainly focused on study of parameters like gonadotropin hormonal profile, serum vitamin D and calcium levels in polycystic ovary disease (PCOD). The study comprised 45 clinically proven polycystic ovary disease patients in the age range of 19-34 years. The biochemical estimations carried out in the study were – Fasting Blood sugar, LH, FSH, prolactin, 25- OH vitamin D and calcium along with anthropometric data. The values obtained were compared with age matched equal number of healthy control female subjects from the same population.Results: The serum concentration of calcium and vitamin D levels are decreased significantly (P <0.001) when compared to controls. Insulin resistance is predominantly seen in PCOS subjects. The study outlines the importance of insulin resistance, dyslipidemia, decreased serum calcium and vitamin D levels in PCOS subjects may be a cause for the progression of polycystic ovary syndrome.Conclusions: In the present study vitamin D deficiency is highly prevalent in PCOS women from this area compared to control women. We also relations of vitamin D status with insulin sensitivity, HDL-C, and C-reactive protein in PCOS patients, which support the increasing evidence that vitamin D deficiency is associated with multiple metabolic risk factors in PCOS women. A high prevalence of vitamin D deficiency and low calcium levels were observed in PCOS women from our population when compared to controls. Insulin resistance was predominantly seen in PCOS subjects when compared with controls, indicating the association of vitamin D levels with insulin resistance.

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Vitamin D and polycystic ovary syndrome: an integrating review

International Archives of Medicine ◽

10.3823/2402 ◽

2017 ◽

Vol 10 ◽

Author(s):

Ione Maria Ribeiro Soares Lopes ◽

Caroliny Gonçalves Rodrigues Meireles ◽

Iarlla Silva Ferreira ◽

Nadya Dos Santos Moura ◽

Francisca Diana Da Silva Negreiros ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Vitamin D Deficiency ◽

Polycystic Ovary ◽

Reproductive Age ◽

Women Of Reproductive Age ◽

Ovary Syndrome ◽

Controversial Subject

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrinopathyin women of reproductive age. It causes a metabolic syndrome characterized by insulin resistance, hyperinsulinemia, and dyslipidemia. Vitamin D deficiency and its association with PCOS still represents a controversial subject in the literature. Objective: In this context, this study aimed to understand the association between polycystic ovary syndrome and vitamin D deficiency, and how it occurs. Method: It was an integrative review conducted in the PubMed, Scopus, LILACS, and CINAHL databases from August 2016 to January 2017, with a sample of 7 articles analyzed in their entirety. Results: The evidences according to the studies conducted and the conclusions they identified. Conclusions: It was concluded that we cannot yet assume that vitamin D deficiency contributes to the pathogenesis of PCOS, nor that the syndrome causes vitamin D deficiency, since the studies are controversial and there is a need for research with higher levels of evidence to clarify these doubts.

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The Effect of Vitamin D3 and Co-enzyme Q10 Supplementation on Metabolic Biomarkers in Women with Clomiphene Citrate Resistant Polycystic Ovary Syndrome

Al Mustansiriyah Journal of Pharmaceutical Sciences ◽

10.32947/ajps.18.02.0384 ◽

2018 ◽

pp. 142-150

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Insulin Sensitivity ◽

Polycystic Ovary Syndrome ◽

Vitamin D3 ◽

Polycystic Ovary ◽

Clomiphene Citrate ◽

Vitamin D Status ◽

Ovary Syndrome ◽

Metabolic Biomarkers

Polycystic ovary syndrome (PCOS) one of the most common endocrine disorders in women of reproductive age, the pathogenesis of PCOS imitated to be as a vicious cycle involving both hyperandrogenaemia and insulin resistance/hyperinsulinemia. Vitamin D deficiency (VDD) is common among women with PCOS (approximately 67%–85% women with PCOS have VDD). Vitamin D3 and CoQ10 could affect glucose metabolism and insulin sensitivity and improve metabolic abnormalities in PCOS. The study was designed to evaluate the effect of combining oral vitamin D3 tablet or CoQ10 capsule with clomiphene citrate on metabolic biomarkers in women with clomiphene citrate resistance PCOS patients. A prospective interventional randomized-controlled, open-label study include 41 PCOS patients aged range (18-34)years who are clomiphene citrate resistant divided into two groups, group 1 (n=24) whose endogenous vitamin D status less than 20ng/ml receive clomiphene citrate 100mg daily(for 5 days monthly induction) plus vitamin D 10000IU daily (2 months) and group 2 (n=17) whose endogenous vitamin D status equal or more than 20ng/ml receive clomiphene citrate 100mg daily(for 5 days monthly induction) plus CoQ10 200mg daily (2 months). Fasting blood samples were taken at baseline and 2 months after intervention to measure metabolic biomarkers [fasting serum insulin (FSI), fasting blood glucose (FBG), homeostatic model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI)]. After 2 months both interventions result in non-significant change in FSI and FBG while HOMA-IR and QUICKI decreased by both interventions, but the decrease is significant only with CoQ10 supplementations. In conclusion, Vitamin D and CoQ10 supplementation result in improvement in HOMA-IR and QUICKI but the improvement was more obvious in CoQ10 group.

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Impact of Vitamin D Deficiency on the Pathogenesis of Polycystic Ovary Syndrome

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) ◽

10.54133/ajms.v2i.53 ◽

2022 ◽

Vol 2 ◽

pp. 1-7

Author(s):

Noor Majid Raheem ◽

Bushra Hassan Marouf

Keyword(s):

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Lipid Profile ◽

Vitamin D3 ◽

Polycystic Ovary ◽

Good Effect ◽

Minor Effect ◽

Ovary Syndrome ◽

Vitamin D Levels ◽

Pcos Group

There are many metabolic and hormonal factors related to polycystic ovary syndrome (PCOS) that can be affected by vitamin D3 supplementation. To find clinical trials, in vivo studies, and in vitro studies that met the review's inclusion and exclusion criteria, we searched many databases. PCOS women's ovulation and metabolic parameters were examined in relation to the effects of vitamin D3 treatment on PCOS risk variables such as seasonal changes in body mass index, and obesity. The current review included twenty-five articles. Vitamin D3(25-hydroxy vitamin D) levels were significantly lower in the PCOS group than in the control group, and lipid profile and androgen hormone levels were significantly higher in the PCOS group, resulting in increased cardiovascular events and exaggerated hirsutism. According to the majority of research, vitamin D3 plays a beneficial role in decreasing the pathophysiology of PCOS, notably in restoring ovulation, which ultimately improves fertility. Although other studies found no effect on lipid profile, there was a minor effect on reducing cardiovascular risks. The response of patients to vitamin D3 was influenced by the dose administered and the study's methodology. In conclusion, vitamin D3 had a good effect on the pathophysiology of PCOS in the majority of investigations.

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