Highly Activated Ex Vivo-expanded Natural Killer Cells in Patients With Solid Tumors in a Phase I/IIa Clinical Study

KAZUHIRO NAGAI; YUI HARADA; HIROSHI HARADA; KATSUNORI YANAGIHARA; YOSHIKAZU YONEMITSU; YASUSHI MIYAZAKI

doi:10.21873/anticanres.14583

Highly Activated Ex Vivo-expanded Natural Killer Cells in Patients With Solid Tumors in a Phase I/IIa Clinical Study

Anticancer Research ◽

10.21873/anticanres.14583 ◽

2020 ◽

Vol 40 (10) ◽

pp. 5687-5700

Author(s):

KAZUHIRO NAGAI ◽

YUI HARADA ◽

HIROSHI HARADA ◽

KATSUNORI YANAGIHARA ◽

YOSHIKAZU YONEMITSU ◽

...

Keyword(s):

Clinical Study ◽

Natural Killer Cells ◽

Phase I ◽

Natural Killer ◽

Solid Tumors ◽

Ex Vivo ◽

Killer Cells

Download Full-text

Combining Dinutuximab with ALT-803 (IL-15 Superagonist) Significantly Improves the Activity of Ex Vivo Expanded Natural Killer Cells Against GD2+ Pediatric Solid Tumors (ST)

Biology of Blood and Marrow Transplantation ◽

10.1016/j.bbmt.2017.12.555 ◽

2018 ◽

Vol 24 (3) ◽

pp. S472-S473

Author(s):

Gaurav Nayyar ◽

Yaya Chu ◽

Nang Kham Su ◽

Jeremy Rosenblum ◽

Hing C. Wong ◽

...

Keyword(s):

Natural Killer Cells ◽

Natural Killer ◽

Solid Tumors ◽

Ex Vivo ◽

Killer Cells ◽

Pediatric Solid Tumors

Download Full-text

Stem cells-derived natural killer cells for cancer immunotherapy: current protocols, feasibility, and benefits of ex vivo generated natural killer cells in treatment of advanced solid tumors

Cancer Immunology Immunotherapy ◽

10.1007/s00262-021-02975-8 ◽

2021 ◽

Author(s):

Hamid Khodayari ◽

Saeed Khodayari ◽

Elmira Ebrahimi ◽

Farimah Hadjilooei ◽

Miko Vesovic ◽

...

Keyword(s):

Stem Cells ◽

Natural Killer Cells ◽

Cancer Immunotherapy ◽

Natural Killer ◽

Solid Tumors ◽

Ex Vivo ◽

Advanced Solid Tumors ◽

Killer Cells

Download Full-text

Faculty Opinions recommendation of Ex vivo-expanded natural killer cells demonstrate robust proliferation in vivo in high-risk relapsed multiple myeloma patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725244212.793522223 ◽

2016 ◽

Author(s):

Parameswaran Hari ◽

Binod Dhakal

Keyword(s):

Multiple Myeloma ◽

High Risk ◽

Natural Killer Cells ◽

Natural Killer ◽

Ex Vivo ◽

Killer Cells

Download Full-text

Potent ex vivo expanded, human CD34+ cord blood-derived natural killer cells for cancer immunotherapy

Journal for ImmunoTherapy of Cancer ◽

10.1186/2051-1426-3-s2-p62 ◽

2015 ◽

Vol 3 (S2) ◽

Author(s):

Xiaokui Zhang ◽

Lin Kang ◽

Ivana Djuretic ◽

Eric Law ◽

Vanessa Voskinarian-Berse ◽

...

Keyword(s):

Natural Killer Cells ◽

Cord Blood ◽

Cancer Immunotherapy ◽

Natural Killer ◽

Ex Vivo ◽

Killer Cells ◽

Human Cd34

Download Full-text

P23. Efficient ex vivo lysis of acute myeloid leukaemic (AML) cells mediated by triplebodies with dual-targeting capability in conjunction with natural killer cells as effectors

Journal for ImmunoTherapy of Cancer ◽

10.1186/2051-1426-2-s2-p14 ◽

2014 ◽

Vol 2 (S2) ◽

Author(s):

G Fey ◽

TA Braciak ◽

S Wildenhain ◽

CC Roskopf ◽

C Schiller ◽

...

Keyword(s):

Natural Killer Cells ◽

Natural Killer ◽

Ex Vivo ◽

Killer Cells ◽

Dual Targeting ◽

Acute Myeloid

Download Full-text

Two-Stage Priming of Allogeneic Natural Killer Cells for the Treatment of Patients with Acute Myeloid Leukemia: A Phase I Trial

PLoS ONE ◽

10.1371/journal.pone.0123416 ◽

2015 ◽

Vol 10 (6) ◽

pp. e0123416 ◽

Cited By ~ 29

Author(s):

Panagiotis D. Kottaridis ◽

Janet North ◽

Maria Tsirogianni ◽

Chloe Marden ◽

Edward R. Samuel ◽

...

Keyword(s):

Acute Myeloid Leukemia ◽

Natural Killer Cells ◽

Phase I ◽

Natural Killer ◽

Myeloid Leukemia ◽

Phase I Trial ◽

Two Stage ◽

Killer Cells ◽

Acute Myeloid

Download Full-text

Carfilzomib combined with ex vivo-expanded patient autologous natural killer cells for myeloma immunotherapy

Neoplasma ◽

10.4149/neo_2018_171019n668 ◽

2018 ◽

Vol 65 (05) ◽

pp. 720-729 ◽

Cited By ~ 4

Author(s):

S.K. CHANG ◽

J. HOU ◽

G.G. CHEN ◽

D.D. YU ◽

H.Q. WU ◽

...

Keyword(s):

Natural Killer Cells ◽

Natural Killer ◽

Ex Vivo ◽

Killer Cells

Download Full-text

Immunophenotypic and functional characterization of ex vivo expanded natural killer cells for clinical use in acute lymphoblastic leukemia patients

Cancer Immunology Immunotherapy ◽

10.1007/s00262-014-1614-z ◽

2014 ◽

Vol 64 (2) ◽

pp. 201-211 ◽

Cited By ~ 12

Author(s):

Nadia Peragine ◽

Giovanni F. Torelli ◽

Paola Mariglia ◽

Simona Pauselli ◽

Antonella Vitale ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Natural Killer Cells ◽

Natural Killer ◽

Ex Vivo ◽

Lymphoblastic Leukemia ◽

Functional Characterization ◽

Clinical Use ◽

Killer Cells

Download Full-text

Potent antitumor efficacy of ex vivo expanded and cryopreserved human natural killer cells against orthotopic pancreatic cancer

Cytotherapy ◽

10.1016/j.jcyt.2019.03.361 ◽

2019 ◽

Vol 21 (5) ◽

pp. S35

Author(s):

G. Park ◽

B. Yang ◽

E. Kim ◽

H. Kim ◽

Y. Kim ◽

...

Keyword(s):

Pancreatic Cancer ◽

Natural Killer Cells ◽

Natural Killer ◽

Ex Vivo ◽

Antitumor Efficacy ◽

Killer Cells ◽

Human Natural Killer Cells

Download Full-text

Ex vivo-expanded natural killer cells kill cancer cells more effectively than ex vivo-expanded γδ T cells or αβ T cells

International Immunopharmacology ◽

10.1016/j.intimp.2014.07.036 ◽

2014 ◽

Vol 22 (2) ◽

pp. 486-491 ◽

Cited By ~ 7

Author(s):

Xuewen Deng ◽

Hiroshi Terunuma ◽

Atsushi Terunuma ◽

Tsubasa Takane ◽

Mie Nieda

Keyword(s):

T Cells ◽

Natural Killer Cells ◽

Cancer Cells ◽

Natural Killer ◽

Ex Vivo ◽

Γδ T Cells ◽

Killer Cells ◽

Αβ T Cells

Download Full-text