scholarly journals Anti-inflammatory and Anti-thrombotic Efficacy of Targeted Ultrasound Microbubbles on LPS-induced HUVEC Cells

2021 ◽  
Vol 41 (10) ◽  
pp. 4761-4769
Author(s):  
JINDONG SUN ◽  
SHIJUN PAN ◽  
HUAMIN YU ◽  
HAIQIANG HU ◽  
YU SUN ◽  
...  
Keyword(s):  
Targeted Ultrasound ◽  
Huvec Cells ◽  
Anti Inflammatory ◽  
Ultrasound Microbubbles

scholarly journals Anti-Inflammatory and Proliferative Properties of Luteolin-7-O-Glucoside

2021 ◽  
Vol 22 (3) ◽  
pp. 1321
Author(s):  
Alessandro De Stefano ◽  
Sabrina Caporali ◽  
Nicola Di Daniele ◽  
Valentina Rovella ◽  
Carmine Cardillo ◽  
...  
Keyword(s):  
Transcriptional Repression ◽  
Antioxidant Property ◽  
Ros Generation ◽  
Organoleptic Characteristics ◽  
Hydroxylated Fatty Acids ◽  
General Production ◽  
Huvec Cells ◽  
Anti Inflammatory ◽  
First Time

Flavonoids display a broad range of structures and are responsible for the major organoleptic characteristics of plant-derived foods and beverages. Recent data showed their activity, and in particular of luteolin-7-O-glucoside (LUT-7G), in reduction of oxidative stress and inflammatory mechanisms in different physiological systems. In this paper, we tried to elucidate how LUT-7G could exert both antioxidant and anti-inflammatory effects in endothelial cells cultured in vitro. Here, we showed that LUT-7G is able to inhibit the STAT3 pathway, to have an antiproliferative action, and an important antioxidant property in HUVEC cells. These properties are exerted by the flavone in endothelial through the transcriptional repression of a number of inflammatory cytokines and their receptors, and by the inhibition of ROS generation. ROS and STAT3 activation has been correlated with the production of oxysterols and other hydroxylated fatty acids, and they have been recognized important as players of atherogenesis and cardiocirculatory system diseases. The analysis of the general production pathway of these hydroxylated species, showed a strong decrease of cholesterol hydroxylated species such as 7-alpha-hydroxicholesterol, 7-beta-hydroxicholesterol by the treatment with LUT-7G. This confirms the anti-inflammatory properties of LUT-7G also in the endothelial district, showing for the first time the molecular pathway that verify previous postulated cardiovascular benefits of this flavone.

RGD-Tagged Microbubbles Generated by Versatile Fabrication Protocols for In Vitro Cell Targeting and In Vivo Mouse Imaging of Tumor Vascularization

2020 ◽  
Vol 12 (5) ◽  
pp. 725-732
Author(s):  
Fangfang Yu ◽  
Jiaping Li ◽  
Yan Yang ◽  
Yueyue Cheng ◽  
Xianwei Ni ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Ultrasound Contrast Agents ◽  
Cell Targeting ◽  
Tumor Vascularization ◽  
Targeted Ultrasound ◽  
One Step ◽  
Functional Biomaterials ◽  
Ultrasound Microbubbles

By using an organic framework to fabricate functional biomaterials, novel design and advanced biomedical applications of polymeric microbubbles for in vivo targeting and disease-oriented imaging of tumor vascularization can be developed. The present study describes novel synthetic protocols to fabricate RGD (Arginine-Glycine-Aspartic)-tagged αvβ3-targeted ultrasound microbubbles. The microbubbles were synthesized by emulsion polymerization techniques. Two types of microbubbles (MBs-1 and MBs-2) were obtained via biotin-streptavidin conjugation to poly(butyl cyanoacrylate) microbubbles (MBs-0) obtained by one-step synthesis in reverse order. The size distributions and surface zeta potentials were characterized. The results showed that the sizes of the MBs-2 were larger than that those of the MBs-1, and the MBs-2 showed decreased charge compared to MBs-1. In cell targeting studies, MBs-2 exhibited relatively stronger targeting affinity for αvβ3 integrins, while MBs-1 showed weaker targeting capability. Furthermore, in vivo mice imaging using MBs-2 for intravenous injection exhibited an obvious and sustained signal increase, which revealed the accumulative of MBs-2 anchoring in tumor. Hence, MBs-2 have been proven to be a promising candidate for using as ultrasound contrast agents for the early diagnosis of αvβ3-overexpressing malignant tumors, including breast cancer.

scholarly journals Development of prostate specific membrane antigen targeted ultrasound microbubbles using bioorthogonal chemistry

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176958 ◽  
Author(s):  
Aimen Zlitni ◽  
Melissa Yin ◽  
Nancy Janzen ◽  
Samit Chatterjee ◽  
Ala Lisok ◽  
...  
Keyword(s):  
Prostate Specific Membrane Antigen ◽  
Bioorthogonal Chemistry ◽  
Targeted Ultrasound ◽  
Ultrasound Microbubbles ◽  
Specific Membrane

Design and Characterization of Targeted Ultrasound Microbubbles for Diagnostic Use

2011 ◽  
Vol 37 (1) ◽  
pp. 136-150 ◽  
Author(s):  
Astrid Hilde Myrset ◽  
Hege Brincker Fjerdingstad ◽  
Ragnar Bendiksen ◽  
Bente Elisabeth Arbo ◽  
Roger Malerbakken Bjerke ◽  
...  
Keyword(s):  
Diagnostic Use ◽  
Targeted Ultrasound ◽  
Ultrasound Microbubbles
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