The Impact of Metastatic Lymph Node Size on Long-term Outcomes for pStage III Colon Cancer

2022 ◽  
Vol 2 (1) ◽  
pp. 31-37
Author(s):  
CHIKARA MAEDA ◽  
YUSUKE YAMAOKA ◽  
AKIO SHIOMI ◽  
HIROYASU KAGAWA ◽  
HITOSHI HINO ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Metastatic Lymph Node ◽  
Long Term Outcomes ◽  
Metastatic Lymph ◽  
Lymph Node Size ◽  
The Impact ◽  
Group D ◽  
Node Size

Aim: To clarify the impact of metastatic lymph node size on long-term outcomes in patients undergoing curative colectomy for pathological stage III colon cancer. Patients and Methods: This study enrolled patients who underwent curative colectomy for pStage III colon cancer between January 2013 and December 2015. All patients were divided into four groups based on the short-axis diameter of the largest MLN: Group A, <5 mm; Group B, ≥5 mm and <10 mm; Group C, ≥10 mm and <15 mm; Group D, ≥15 mm. Results: A total of 209 patients were analyzed. The 5-year recurrence-free survival rates of Groups A, B, C, and D were 82.3%, 74.6%, 74.5% and 60.7%, respectively. In multivariate analysis, Group D (hazard ratio=3.95; 95% confidence interval, 1.34-11.65; p=0.01) was independently associated with worse RFS. Conclusion: Bulky MLNs might be a poor prognostic factor in node-positive colon cancer.

scholarly journals The Impact of Metastatic Lymph Node Size on Long-Term Outcomes Following Curative Colectomy for Pathological Stage III Colon Cancer

2021 ◽  
Author(s):  
Chikara Maeda ◽  
Yusuke Yamaoka ◽  
Akio Shiomi ◽  
Hiroyasu Kagawa ◽  
Hitoshi Hino ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Multivariate Analysis ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Metastatic Lymph Node ◽  
Long Term Outcomes ◽  
Stage Iii Colon Cancer ◽  
The Impact ◽  
Group D

Abstract Background: In node-positive colon cancer, the impact of MLN size on prognosis is controversial. The aim of this study was to clarify the impact of metastatic lymph node (MLN) size on long-term outcomes in patients undergoing curative resection for pStage III colon cancer.Methods: This study enrolled patients who underwent curative colectomy for pStage III colon cancer between January 2013 and December 2015. All eligible patients were divided into four groups based on the short-axis diameter of the largest MLN: Group A, < 5 mm; Group B, ≥ 5 mm and < 10 mm; Group C, ≥ 10 mm and < 15 mm; and Group D, ≥ 15 mm. We performed univariate and multivariate analysis using Cox proportional hazard regression models to identify clinicopathological factors affecting recurrence-free survival (RFS).Results: A total of 209 patients were analyzed. We evaluated 7305 LNs, of which 644 were metastatic. The 5-year RFS rates of Groups A, B, C, and D were 82.3%, 74.6%, 74.5%, and 60.7%, respectively. In univariate analysis, age older than 70 years, Group D (largest MLN ≥ 15 mm), and the absence of adjuvant chemotherapy were significantly associated with RFS. In multivariate analysis, Group D (hazard ratio [HR], 3.95; 95% confidence interval [CI], 1.34–11.65; p=0.01) and the absence of adjuvant chemotherapy (HR, 2.44; 95% CI, 1.26-4.72; p<0.01) were independently associated with worse RFS.Conclusion: A maximum MLN ≥ 15 mm was significantly associated with worse RFS in stage III colon cancer. Bulky MLNs might be a poor prognostic factor in node-positive colon cancer.

Large Metastatic Lymph Node Size, Especially More Than 2 cm: Independent Predictor of Poor Prognosis in Node-Positive Gastric Carcinoma

2007 ◽  
Vol 32 (2) ◽  
pp. 262-266 ◽  
Author(s):  
O. Cheong ◽  
S. T. Oh ◽  
B. S. Kim ◽  
J. H. Yook ◽  
J. H. Kim ◽  
...  
Keyword(s):  
Lymph Node ◽  
Gastric Carcinoma ◽  
Poor Prognosis ◽  
Independent Predictor ◽  
Metastatic Lymph Node ◽  
Node Positive ◽  
Metastatic Lymph ◽  
Lymph Node Size ◽  
Node Size

The Impact of Preoperative Lymph Node Size on Long-Term Outcome Following Curative Gastrectomy for Gastric Cancer

2012 ◽  
Vol 20 (5) ◽  
pp. 1598-1603 ◽  
Author(s):  
Masanori Tokunaga ◽  
Norihiko Sugisawa ◽  
Yutaka Tanizawa ◽  
Etsuro Bando ◽  
Taiichi Kawamura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Curative Gastrectomy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Lymph Node Size ◽  
The Impact ◽  
Node Size

scholarly journals Nodal stage of stage III colon cancer: The impact of metastatic lymph node ratio

2009 ◽  
Vol 100 (3) ◽  
pp. 240-243 ◽  
Author(s):  
In Ja Park ◽  
Gyu-Seog Choi ◽  
Soo Han Jun
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Nodal Stage ◽  
Metastatic Lymph ◽  
Node Ratio ◽  
The Impact

Prognostic significance of metastatic lymph node size in patients with gastric cancer

2003 ◽  
Vol 90 (12) ◽  
pp. 1522-1530 ◽  
Author(s):  
D. K. Dhar ◽  
H. Kubota ◽  
N. Kinukawa ◽  
R. Maruyama ◽  
I. D. Kyriazanos ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Metastatic Lymph Node ◽  
Prognostic Significance ◽  
Metastatic Lymph ◽  
Lymph Node Size ◽  
Node Size

Metastatic lymph node size and colorectal cancer prognosis

2005 ◽  
Vol 200 (1) ◽  
pp. 20-28 ◽  
Author(s):  
Dipok Kumar Dhar ◽  
Hiroshi Yoshimura ◽  
Naoko Kinukawa ◽  
Riruke Maruyama ◽  
Mitsuo Tachibana ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Metastatic Lymph Node ◽  
Cancer Prognosis ◽  
Metastatic Lymph ◽  
Lymph Node Size ◽  
Node Size

scholarly journals The impact of major postoperative complications on long-term outcomes following curative resection of colon cancer

2018 ◽  
Vol 52 ◽  
pp. 303-308 ◽  
Author(s):  
Javier A. Cienfuegos ◽  
Jorge Baixauli ◽  
Carmen Beorlegui ◽  
Patricia Martínez Ortega ◽  
Lucía Granero ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Postoperative Complications ◽  
Curative Resection ◽  
Long Term Outcomes ◽  
The Impact

Does small volume metastatic lymph node disease affect long-term prognosis in early cervical cancer?

2020 ◽  
Vol 159 ◽  
pp. 190-191
Author(s):  
A.I. Nica ◽  
L.T. Gien ◽  
S.E. Ferguson ◽  
A.L. Covens
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Small Volume ◽  
Metastatic Lymph Node ◽  
Lymph Node Disease ◽  
Metastatic Lymph ◽  
Node Disease ◽  
Long Term Prognosis ◽  
Early Cervical Cancer

Lymph node size as a simple prognostic factor in node negative colon cancer and an alternative thesis to stage migration

2016 ◽  
Vol 212 (4) ◽  
pp. 775-780 ◽  
Author(s):  
Bruno Märkl ◽  
Tina Schaller ◽  
Yuriy Kokot ◽  
Katharina Endhardt ◽  
Hallie Kretsinger ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Stage Migration ◽  
Node Negative ◽  
Lymph Node Size ◽  
Node Size

The role of lymph node size and FOXP3+ regulatory T cells in node-negative colon cancer

2016 ◽  
Vol 70 (5) ◽  
pp. 443-447 ◽  
Author(s):  
Bruno Märkl ◽  
Beate Paul ◽  
Tina Schaller ◽  
Hallie Kretsinger ◽  
Bernadette Kriening ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cells ◽  
Lymph Node ◽  
Regulatory T Cells ◽  
Node Negative ◽  
Lymph Node Size ◽  
Node Size
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