This chapter attempts a review of the dominant issues relating to theoretical, conceptual and methodological directions in public health communication discourse. Through a combination of descriptive and meta-analytical reviews, the chapter analyses evidences from past studies in the field of public health communication with the aim of summarizing findings in order to find a clear path for future direction of research in this area. There is, therefore, efforts in the chapter at reviewing the major theoretical foundations that have driven scholarly discussions in this field from individual to interpersonal, community and institutional perspectives. The chapter also discusses wide raging conceptual issues relating to reproductive health, maternal mortality, child survival, mental health, infectious diseases as well as accident, trauma and emergency. Diverse methods used in studying public health communication were also reviewed in the chapter.