scholarly journals Incorporation of Personal Single Nucleotide Polymorphism (SNP) Data into a National Level Electronic Health Record for Disease Risk Assessment, Part 3: An Evaluation of SNP Incorporated National Health Information System of Turkey for Prostate Cancer

2014 ◽  
Vol 2 (2) ◽  
pp. e21 ◽  
Author(s):  
Timur Beyan ◽  
Yeşim Aydın Son
Keyword(s):  
Prostate Cancer ◽  
Risk Assessment ◽  
Information System ◽  
Disease Risk ◽  
National Level ◽  
Health Information System ◽  
Health Record ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Snp Data

A single nucleotide polymorphism in the E-cadherin gene promoter modifies the risk of prostate cancer

2002 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
Bas Verhage ◽  
Kjeld van Houwelingen ◽  
Emiel Ruijter ◽  
Bart Kiemeney ◽  
Jack Schalken
Keyword(s):  
Prostate Cancer ◽  
Single Nucleotide Polymorphism ◽  
Gene Promoter ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
E Cadherin

In silico analysis of non-synonymous single nucleotide polymorphism in a human KLK-2 gene associated with prostate cancer

Meta Gene ◽  
2019 ◽  
Vol 21 ◽  
pp. 100578
Author(s):  
Tooba Yousefi ◽  
Seyed Mostafa Mir ◽  
Jahanbakhsh Asadi ◽  
Mehdi Tourani ◽  
Ansar Karimian ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Nucleotide Polymorphism ◽  
In Silico ◽  
In Silico Analysis ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Silico Analysis

scholarly journals Interspecific Genetic Differences and Historical Demography in South American Arowanas (Osteoglossiformes, Osteoglossidae, Osteoglossum)

Genes ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 693 ◽  
Author(s):  
Souza ◽  
Perez ◽  
Bertollo ◽  
Oliveira ◽  
Lavoué ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Amazon Basin ◽  
Taxonomic Status ◽  
Learning Approach ◽  
Anthropogenic Pressure ◽  
South American ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Demographic Models ◽  
Snp Data

The South American arowanas (Osteoglossiformes, Osteoglossidae, Osteoglossum) are emblematic species widely distributed in the Amazon and surrounding basins. Arowana species are under strong anthropogenic pressure as they are extensively exploited for ornamental and food purposes. Until now, limited genetic and cytogenetic information has been available, with only a few studies reporting to their genetic diversity and population structure. In the present study, cytogenetic and DArTseq-derived single nucleotide polymorphism (SNP) data were used to investigate the genetic diversity of the two Osteoglossum species, the silver arowana O. bicirrhosum, and the black arowana O. ferreirai. Both species differ in their 2n (with 2n = 54 and 56 for O. ferreirai and O. bicirrhosum, respectively) and in the composition and distribution of their repetitive DNA content, consistent with their taxonomic status as different species. Our genetic dataset was coupled with contemporary and paleogeographic niche modeling, to develop concurrent demographic models that were tested against each other with a deep learning approach in O. bicirrhosum. Our genetic results reveal that O. bicirrhosum colonized the Tocantins-Araguaia basin from the Amazon basin about one million years ago. In addition, we highlighted a higher genetic diversity of O. bicirrhosum in the Amazon populations in comparison to those from the Tocantins-Araguaia basin.

scholarly journals rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report

2019 ◽  
Vol 6 (4) ◽  
pp. 37 ◽  
Author(s):  
Ali Salami ◽  
Christy Costanian ◽  
Said El Shamieh
Keyword(s):  
Disease Risk ◽  
Middle Eastern ◽  
Cardiovascular Disease Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Multiethnic Population ◽  
Cluster Of Differentiation

Many studies have assessed the implication of cluster of differentiation 14 (CD14) molecules and its single nucleotide polymorphism rs2569190A>G with different complex diseases, such as diabetes and cardiovascular diseases (CVDs). In this study, we investigated the association of rs2569190A>G in CD14 with cardiovascular disease risk factors (hypercholesterolemia and hypertension) in 460 individuals from the general Lebanese population (Middle Eastern multiethnic population). Using a multiple logistic regression model adjusted for six covariates (under additive and recessive assumptions), we found that the G allele of rs2569190 in CD14 was associated with increased levels of total cholesterol (OR = 3.10, p = 0.009), low-density lipoprotein cholesterol (OR = 3.87, p = 0.003), and decreased levels of high-density lipoprotein cholesterol (OR = 0.38, p = 0.001). In contrast, no significant relationship was found with hypertension. Thus, we concluded that rs2569190G in CD14 is associated with a higher risk of developing hypercholesterolemia.

scholarly journals Single-Nucleotide Polymorphism–Based Genetic Risk Score and Patient Age at Prostate Cancer Diagnosis

2019 ◽  
Vol 2 (12) ◽  
pp. e1918145
Author(s):  
Rong Na ◽  
Craig Labbate ◽  
Hongjie Yu ◽  
Zhuqing Shi ◽  
Richard J. Fantus ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Nucleotide Polymorphism ◽  
Risk Score ◽  
Cancer Diagnosis ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Nucleotide Polymorphism ◽  
Patient Age ◽  
Single Nucleotide ◽  
Prostate Cancer Diagnosis
Sign in / Sign up

Export Citation Format

Share Document